Identifying the Roles of Interleukin-13 in Childhood Asthma

DOI: 10.4236/oalib.1100468   PDF        847 Downloads   1,134 Views  

Abstract

Asthma is a chronic inflammatory disease of the airways manifested by reversible airflow obstruction and airway hyperresponsiveness. While recent research has mapped several genes as possible factors predisposing to asthma, interleukin-13 remains one of the most commonly found genes in various populations. IL-13 is a pleiotropic TH2 cytokine which has been linked to cause an increase in goblet cell differentiation, activation of fibroblasts, elevation of bronchial hyperresponsiveness and switching of B cell antibody from IgM to IgE. The aim of this review is to study and identify the three main single-nucleotide polymorphisms of IL-13 (IL13 R130Q, IL-13Rα1 and IL-13 A2044G) that have been linked to asthma in children, and to understand their respective roles in the pathogenesis of this disease.

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Ramphul, K. (2014) Identifying the Roles of Interleukin-13 in Childhood Asthma. Open Access Library Journal, 1, 1-5. doi: 10.4236/oalib.1100468.

Conflicts of Interest

The authors declare no conflicts of interest.

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