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Therapeutic Applications of Vitamin D Supplementation on Type 2 Diabetes

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DOI: 10.4236/oalib.1100333    862 Downloads   1,352 Views   Citations
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ABSTRACT

Background: Many studies have found that vitamin D deficiency is associated with impaired human insulin action, suggesting a role in the pathogenesis of diabetes mellitus type 2 (T2DM). This study investigated the effects of vitamin D3 supplementation on serum HbA1c values and 25(OH) vitamin D concentrations in healthy and diabetic individuals. Methods: 722 individuals aged from 36 to 61 years old were selected (360 males and 362 females) divided into two groups. Healthy male group consisted of 180 person with HbA1c value (6.78 ± 2.14) and 180 persons diagnosed with type 2 diabetes (HbA1c 11.64 ± 3.85). The healthy female group had also 180 person (HbA1c 7.42 ± 2.86) and 182 diabetic females (HbA1c 11.43 ± 2.88). Each group was then divided into two subgroups. One supplemented with (2000 IU/day) of vitamin D for 90 days and the other one was not given any vitamin D supplements. HbA1c and serum 25(OH) vitamin D were recorded. Results: Mean serum HbA1c values for both males and females improved with vitamin D supplementations but the improvement was significant in the diabetic group (males and females) comparing with healthy group. Serum HbA1c in healthy group improved by 4.8% and 2.7% for males and females respectively whereas serum HbA1c for diabetic group declined by 13.4% and 21.8% for group 7 - 9 and 9.6 and 22.1% for group > 9 for males and females respectively. Also, serum 25(OH) vitamin D concentrations improved dramatically with supplementation in healthy and diabetic groups. 25(OH) vitamin D for the healthy males improved by 67.9% and for healthy females 47.7% whereas for diabetic males and females improved by 53% and 31.7% and 56.6% and 77.2% for males and females HbA1c 7 - 9 and for HbA1c > 9 respectively. Conclusion: Vitamin D supplementation lowered serum HbA1c values of males and females especially in the group Hba1c values > 9 and this can be considered as a cheap and effective therapeutic tool in the management of type 2 diabetes. Also vitamin D supplementation improved concentration of serum 25(OH) vitamin D in both healthy and diabetic group upgrading their vitamin D status from deficiency to sufficiency.

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The authors declare no conflicts of interest.

Cite this paper

Labban, L. (2014) Therapeutic Applications of Vitamin D Supplementation on Type 2 Diabetes. Open Access Library Journal, 1, 1-10. doi: 10.4236/oalib.1100333.

References

[1] International Diabetes Federation (IDF) (2011) Diabetes Atlas Global Burden, Epidemiology and Morbidity. Diabetes and Impaired Glucose Tolerance.
http://www.diabetesaltas.org/content/diabetes-and-impaired-glucose-tolerance
[2] Hyppönen, E., Läärä, E., Reunanen, A., Järvelin, M. and Virtanen, S. (2001) Intake of Vitamin D and Risk of Type 1 Diabetes: A Birth-Cohort Study. Lancet, 358, 1500-1503.
[3] James, W.P.T. (2008) 22nd Marabou Symposium: The Changing Faces of Vitamin D. Nutrition Reviews, 66, 286-290.
http://dx.doi.org/10.1111/j.1753-4887.2008.00034.x
[4] Lips, P. (2007) Vitamin D Status and Nutrition in Europe and Asia. The Journal of Steroid Biochemistry and Molecular Biology, 103, 620-625.
http://dx.doi.org/10.1016/j.jsbmb.2006.12.076
[5] Parfitt, A.M., Gallagher, J.C., Heaney, R.P., Johnston, C.C., Neer, R. and Whedon, G.D. (1982) Vitamin D and Bone Health in the Elderly. The American Journal of Clinical Nutrition, 36, 1014-1031.
[6] Peacoak, M. (1998) Effect of Calcium and Vitamin D Insufficiency on the Skeleton. Osteoporosis International, 8, S45-S51.
http://dx.doi.org/10.1007/PL00022733
[7] Deluca, H.F. (1988) The Vitamin D Story: A Collaborative Effort of Basic Science and Clinical Medicine. The FASEB Journal, 2, 224-236.
[8] Bouillon, R. (2001) Vitamin D: Photosynthesis, Metabolism, and Action to Clinical Applications. In: Degroot, L., Jameson, J.L. and Burger, H.G., Eds., Endocrinology, 3rd Edition, WB Saunders, Philadelphia, 1009-1028.
[9] Bouillon, R., Carmeliet, G., Daci, E., et al. (1998) Vitamin D Metabolism and Action. Osteoporosis International, 8, S13-S19.
http://dx.doi.org/10.1007/PL00022727
[10] Holick Michael, F. (2010) The Vitamin D Deficiency Pandemic: A Forgotten Hormone Important for Health. Public Health Reviews, 32, 267-283.
[11] Wang, H., Xia, N., Yang, Y. and Peng, D.-Q. (2012) Influence of Vitamin D Supplementation on Plasma Lipid Profiles: A Meta-Analysis of Randomized Controlled Trials. Lipids in Health and Disease, 11, 42.
[12] Alvarez, J.A. and Ashraf, A. (2010) Role of Vitamin D in Insulin Secretion and Insulin Sensitivity for Glucose Homeostasis. International Journal of Endocrinology, 2010, Article ID: 351385.
[13] Afsaneh, T., Mahnaz, M. and Zahra, A. (2013) The Effect of Vitamin D on Insulin Resistance in Patients with Type 2 Diabetes. Diabetology & Metabolic Syndrome, 5, 8.
[14] Muszkat, P., Camargo, M.B.R., Griz, L.H.M. and Lazaretti-Castro, M. (2010) Evidence-Based Non-Skeletal Actions of Vitamin D. Arquivos Brasileiros de Endocrinologia & Metabologia, 54, 110-117.
http://dx.doi.org/10.1590/S0004-27302010000200005
[15] Attila, C., Knekt, P., Männistö, S., Rissanen, H., Laaksonen, M.A., Montonen, J. and Reunanen, A. (2007) Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk Of type 2 Diabetes. Diabetes Care, 30, 2569-2570.
http://dx.doi.org/10.2337/dc07-0292
[16] Al-Daghri, N.M., Alkharfy, K.M., Al-Othman, A., El-Kholie, E., Moharram, O., Alokail, M.S., Al-Saleh, Y., Sabico, S., Kumar, S. and Chrousos, G.P. (2012) Vitamin D Supplementation as an Adjuvant Therapy for Patients with T2DM: An 18-Month Prospective Interventional Study. Cardiovascular Diabetology, 11, 85.
[17] Harris, S.S. (2011) Does Vitamin D Deficiency Contribute to Increased Rates of Cardiovascular Disease and Type 2 Diabetes in African Americans. The American Journal of Clinical Nutrition, 93, 1175S-1178S.
http://dx.doi.org/10.3945/ajcn.110.003491
[18] Boucher, B.J. (2006) Hypovitaminosis D and Risk of Type 2 Diabetes in British South Asians. Diabetic Medicine, 23, 336.
http://dx.doi.org/10.1111/j.1464-5491.2006.01825a.x
[19] Nsiah-Kumi, P.A., Erickson, J.M., Beals, J.L., Ogle, E.A., Whiting, M., Brushbreaker, C., Borgeson, C.D., Qiu, F., Yu, F. and Larsen, J.L. (2012) Vitamin D Insufficiency Is Associated with Diabetes Risk in Native American Children. Clinical Pediatrics (Phila), 51, 146-153.
http://dx.doi.org/10.1177/0009922811417290
[20] Heshmat, R., Tabatabaei-Malazy, O., Abbaszadeh-Ahranjani, S., Shahbazi, S., Khooshehchin, G., Bandarian, F. and Larijani B. (2012) Effect of Vitamin D on Insulin Resistance and Anthropometric Parameters in Type 2 Diabetes; a Randomized Double-Blind Clinical Trial. DARU Journal of Pharmaceutical Sciences, 20, 10.
http://dx.doi.org/10.1186/2008-2231-20-10
[21] Institute of Medicine (2010) Dietary Reference Intakes for Calcium and Vitamin D. National Academies Press, Washington DC.
[22] Holick, M.F. (2007) Vitamin D Deficiency. The New England Journal of Medicine, 357, 266-281.
http://dx.doi.org/10.1056/NEJMra070553
[23] Jorde, R. and Figenschau, Y. (2009) Supplementation with Cholecalciferol Does Not Improve Glycaemic Control in diabetic Subjects with Healthy Serum 25-Hydroxyvitamin D Levels. European Journal of Nutrition, 48, 349-354.
http://dx.doi.org/10.1007/s00394-009-0020-3
[24] Chagas, C.E.A., Borges, M.C., Martini, L.A. and Rogero, M.M. (2012) Focus on Vitamin D, Inflammation and Type 2 Diabetes. Nutrients, 4, 52-67.
[25] Pittas, A.G., Sun, Q., Manson, J.E., Dawson-Hughes, B. and Hu, F.B. (2010) Plasma 25-Hydroxyvitamin D Concentration and Risk of Incident Type 2 Diabetes in Women. Diabetes Care, 33, 2021-2023.
http://dx.doi.org/10.2337/dc10-0790
[26] Iyidir, O.T. and Alt1nova, A.E. (2012) Vitamin D and Diabetes Mellitus. Turkish Journal of Endocrinology and Metabolism, 16, 89-94.
[27] Schwalfenberg, G. (2008) Vitamin D and Diabetes: Improvement of Glycemic Control with Vitamin D3 Repletion. Canadian Family Physician, 54, 864-866.

  
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