Original Article Inhibitory Effect of Ginsenoside Rg3 on Ovarian Cancer Metastasis

DOI:                 

Abstract

Ginsenosides are main components extracted from ginseng, and ginsenoside Rg3 is one of the most important parts. Ginsenoside Rg3 has been found to inhibit several kinds of tumor growth and metastasis. The present study was under-taken to investigate the effect of ginsenoside Rg3 on human ovarian cancer metastasis and the possible mechanism. The experimental lung metastasis models of ovarian cancer SKOV-3 and the assay of tumor-induced angiogenesis were used to observe the inhibitory effects of Rg3 on tumor metastasis and angiogenesis. The effect of Rg3 on invasive ability of SKOV-3 cells in vitro was detected by Boyden chamber, and immunofluorescence staining was used to recognize the expression of matrix metalloproteinase 9 (MMP-9) in SKOV-3 cells. Ginsenoside Rg3 can significantly inhibit the me-tastasis of ovarian cancer. The inhibitory effect is partially due to inhibition of tumor-induced angiogenesis and de-crease of invasive ability and MMP-9 expression of SKOV-3 cells.

Keywords

ginseng, neoplasm, metastasis, angiogenesis, ovarian cancer

Conflicts of Interest

The authors declare no conflicts of interest.

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