Correlation between Dietary Intake and Inflammatory Biomarkers in a Tunisian Obese Group


Aims: This study aims to determine the inflammatory status and evaluate the correlation between dietary intake and inflammatory biomarkers in a Tunisian obese group. Material and Methods: This is an open cross-sectional study that includes 81 individuals divided into two groups: a group of 42 obese patients recruited from the endocrinology department and a control group of 39 non-obese healthy subjects. All participants received a food survey, anthropometric measurements and blood sampling. Pro-inflammatory cytokines (IL-6, IL-8, TNF-α), and hs-CRP were measured in patients and controls. Results: Dietary data revealed significant increases in food intake in obese patients compared to controls. The results of the laboratory parameters showed a statistically significant increase in IL-8, TNF-α and blood glucose in obese compared to controls. The analysis of correlations among the parameters studied showed that the plasma level of IL-6 was positively correlated with dietary fat intake (r = 0.70; p < 10-3) and carbohydrate (r = 0.54; p = 0.03) and the dietary intake expressed in calories (r = 0.64; p < 10-3). Conclusion: dietary imbalances in obese were observed and characterized by an excessive intake of calories, fat and carbohydrates. The excessive carbohydrate and fat intake is associated with increased IL-6 and TNF-α plasma levels.

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Ayoub, M. , Zouaoui, C. , Grira, N. , Kochkar, R. , Stambouli, N. , Bouguerra, C. , Zidi, B. , Ghazouani, E. , Mazigh, C. and Aouni, Z. (2015) Correlation between Dietary Intake and Inflammatory Biomarkers in a Tunisian Obese Group. Journal of Biosciences and Medicines, 3, 108-113. doi: 10.4236/jbm.2015.311014.

Conflicts of Interest

The authors declare no conflicts of interest.


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