Relationship between Serum Levels of Some Trace Elements, Disease Duration and Severity in Patients with Knee Osteoarthritis


Background: Many trace elements in the biological system, including boron, are involved in various vital processes related to health and diseases. Boron has been proved to have a role in decreasing inflammatory pain, joint stiffness and other disabling symptoms associated with osteoarthritis (OA). Aims and Objective: The purpose of the present study was to evaluate the relationship between serum concentrations of copper (Cu), zinc (Zn), selenium (Se), manganese (Mn) and magnesium (Mg) with disease duration and severity in patients with knee OA. Methods: A total of 43 patients with knee OA were clinically evaluated and serum concentrations of Cu, Zn, Se, Mn and Mg were measured, and the results were compared with those of healthy controls. Trace elements levels were correlated with disease duration and severity. Results: Serum Cu and the value of Cu/Zn were significantly elevated in OA patients and positively correlated with disease duration and severity. Serum Zn, Se and Mn were significantly lower in patients compared with controls; Zn and Se were found to be negatively and significantly correlated with disease duration and severity. Conclusion: Patients with knee OA had higher levels of Cu and larger value of Cu/Zn and lower levels of serum Zn and Se; these changes were potentially correlated with the duration and severity of disease.

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Mahmood, N. (2015) Relationship between Serum Levels of Some Trace Elements, Disease Duration and Severity in Patients with Knee Osteoarthritis. Pharmacology & Pharmacy, 6, 489-495. doi: 10.4236/pp.2015.611051.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Roush, J.K., McLaughlin, R.M. and Radlinsky, M.G. (2002) Understanding the Pathophysiology of Osteoarthritis. Veterinary Medicine, 97, 108-117.
[2] Haskin, C.L., Milam, S.B. and Cameron, I.L. (1995) Pathogenesis of Degenerative Joint Disease in the Human Temporomandibular Joint. Critical Review in Oral Biology and Medicine, 6, 248-277.
[3] He, G., Chen, X., Zhang, G., Lin, H., Li, R. and Wu, X. (2014) Detection of Urine C2C and Trace Element Level in Patients with Knee Osteoarthritis. Cell Biochemistry and Biophysics, 70, 475-479.
[4] Krachler, M. and Domej, W. (2001) Clinical Laboratory Parameters in Osteoarthritic Knee-Joint Effusions Correlated to Trace Element Concentrations. Biological Trace Element Research, 79, 139-148.
[5] Shakibaei, M., Kociok, K., Forster, C., Vormann, J., Gunther, T., Stahlmann, R. and Merker, H.J. (1996) Comparative Evaluation of Ultrastructural Changes in Articular Cartilage of Ofloxacin-Treated and Magnesium-Deficient Immature Rats. Toxicology and Pathology, 24, 580-587.
[6] King, D.E., Mainous, A.G., Geesey, M.E. and Woolson, R.F. (2005) Dietary Magnesium and C-Reactive Protein Levels. Journal of American College of Nutrition, 24, 166-171.
[7] Henrotin, Y., Kurz, B. and Aigner, T. (2005) Oxygen and Reactive Oxygen Species in Cartilage Degradation: Friends or Foes? Osteoarthritis and Cartilage OARS, 13, 643-654.
[8] Kurz, B., Jost, B. and Schunke, M. (2002) Dietary Vitamins and Selenium Diminish the Development of Mechanically Induced Osteoarthritis and Increase the Expression of Antioxidative Enzymes in the Knee Joint of STR/1N Mice. Osteoarthritis and Cartilage OARS, 10, 119-126.
[9] Gaby, A.R. (1999) Natural Treatments for Osteoarthritis. Alternative Medicine Reviews, 4, 330-341.
[10] ACR (2000) American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheumatism, 43, 1905-1915.
[11] Ahlback, S. (1968) Osteoarthrosis of the Knee: A Radiographic Investigation. Acta Radiologica Stockholm, 277, 7-72.
[12] Spector, T. and Hart, D. (1992) How Serious Is Knee Osteoarthritis? Annals of Rheumatic Diseases, 51, 1105-1106.
[13] Leibovitz, A., Lubart, E., Wainstein, J., Dror, Y. and Segal, R. (2009) Serum Trace Elements in Elderly Frail Patients with Oropharyngeal Dysphagia. Journal of Nutrition Science and Vitaminology, 55, 407-411.
[14] Shenkin, A. (2009) Selenium in Intravenous Nutrition. Gastroenterology, 137, 61-69.
[15] Tulpar, S., Gunduz, Z., Sahin, U., Poyrazoglu, M.H., Dursun, I., Dusunse, R. and Bastug, F. (2014) Trace Elements in Children Suffering from Idiopathic Nephrotic Syndrome. Eurasian Journal of Medicine, 46, 187-191.
[16] Mishra, O.P., Gupta, A.K., Prasad, R., et al. (2011) Antioxidant Status of Children with Idiopathic Nephrotic Syndrome. Pediatric Nephrology, 26, 251-256.
[17] Yazar, M., Sarban, S., Kocyigit, A. and Isikan, U.E. (2005) Synovial Fluid and Plasma Selenium, Copper, Zinc, and Iron Concentrations in Patients with Rheumatoid Arthritis and Osteoarthritis. Biological Trace Element Research, 106, 123-132.
[18] Strecker, D., Mierzecki, A. and Radomska, K. (2013) Copper Levels in Patients with Rheumatoid Arthritis. Annals of Agricultural and Environmental Medicine, 20, 312-316.
[19] Milanino, R., Frigo, A., Bambara, L.M., Marrella, M., Moretti, U., Pasqualicchio, M., Biasi, D., Gasperini, R., Mainenti, L. and Velo, G.P. (1993) Copper and Zinc Status in Rheumatoid Arthritis: Studies of Plasma, Erythrocytes, and Urine, and Their Relationship to Disease Activity Markers and Pharmacological Treatment. Clinical and Experimental Rheumatology, 11, 271-281.
[20] Shams, S., Ashrafi, M., Noori, M., Irani, H., Ashtiani, M. and Mohseni, A. (2007) Selenium and Glutathione Peroxidase Deficiency in Epileptic Children. Iran Journal of Pediatrics, 17, 173-178.
[21] Thomson, C.D. (2004) Assessment of Requirements for Selenium and Adequacy of Selenium Status: A Review. European Journal of Clinical Nutrition, 58, 391-402.
[22] Shin, E.J., Jeong, J.H., Chung, Y.H., Kim, W.K., Ko, K.H., Bach, J.H., et al. (2011) Role of Oxidative Stress in Epileptic Seizures. Neurochemistry International, 59, 122-137.
[23] Bowman, A.B., Kwakye, G.F., Herrero-Hernandez, E. and Aschner, M. (2011) Role of Manganese in Neurodegenerative Diseases. Journal of Trace Elements in Medicine and Biology, 25, 191-203.
[24] Malecki, E.A. (2001) Manganese Toxicity Is Associated with Mitochondrial Dysfunction and DNA Fragmentation in Rat Primary Striatal Neurons. Brain Research Bulletin, 55, 225-228.
[25] Chan, S., Gerson, B. and Subramaniam, S. (1998) The Role of Copper, Molybdenum, Selenium, and Zinc in Nutrition and Health. Clinical Laboratory Medicine, 18, 673-685.

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