Synthesis and Characterization of Fe3O4 Coated on APTES as Carriers for Morin-Anticancer Drug

DOI: 10.4236/jbnb.2015.64025   PDF   HTML   XML   5,286 Downloads   6,419 Views   Citations


Morin (MR) is an anticancer drug present in fruits and Chinese herbs. Fe3O4 magnetic nanoparticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for MR. The characterization of drug delivery system was confirmed by Fourier Transform Infrared (FTIR), Transmission Electron Microscope (TEM), X-Ray Diffraction (XRD), dynamic light scattering (DLS), and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The TEM image showed that the average particle size is obtained to be about 26.7 nm for MNPs-APTES. The MR loading and release behavior of MNPs-APTES were studied and the results showed that up to 60% of the adsorbed drug was released within 4 h. In summary, the MNPs-APTES nanocarriers are based on the results, promising for targeted morin drug delivery.

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Saif, B. , Wang, C. , Chuan, D. and Shuang, S. (2015) Synthesis and Characterization of Fe3O4 Coated on APTES as Carriers for Morin-Anticancer Drug. Journal of Biomaterials and Nanobiotechnology, 6, 267-275. doi: 10.4236/jbnb.2015.64025.

Conflicts of Interest

The authors declare no conflicts of interest.


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