Synthesis, Characterization and Biological Screening of Ferulic Acid Derivatives

T. Naga Ravi Kiran; Ch. Sri Alekhya; B. V. S. Lokesh; A. V. S. Madhu Latha; Y. Rajendra Prasad; T. Naga Mounika

doi:10.4236/jct.2015.610100

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JCT> Vol.6 No.10, September 2015

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Synthesis, Characterization and Biological Screening of Ferulic Acid Derivatives

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DOI: 10.4236/jct.2015.610100 3,464 Downloads 4,366 Views Citations

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T. Naga Ravi Kiran^1*, Ch. Sri Alekhya¹, B. V. S. Lokesh¹, A. V. S. Madhu Latha², Y. Rajendra Prasad¹, T. Naga Mounika¹

Affiliation(s)

¹Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India.
²Nalanda Institute of Pharmaceutical Sciences, Sattenapalli, Guntur, India.

ABSTRACT

According to WHO, cancer is a leading cause of death worldwide, accounting for 8.2 million deaths in 2012. Among several factors involved in the pathogenesis of cancer, free radical formation followed by damage to DNA and cell protein is one of the causes. Natural plant products have gained enormous interest in the prevention or treatment of chronic diseases. Ferulic acid, like other phenolic acids (caffeic acid, sinapic acid) possess anti cancer activity. A series of ferulic esters (FE1 - FE11) and ferulic amides (FA1 - FA10) were synthesized and evaluated for their cytotoxic activity.

KEYWORDS

Ferulic Acid, Cytotoxicity, Hela (Cervical Cancer Cell Lines), A549 (Lung Cancer Cell Lines), HT-29 (Colorectal Cancer Cell Lines), Synthesis

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Kiran, T. , Alekhya, C. , Lokesh, B. , Latha, A. , Prasad, Y. and Mounika, T. (2015) Synthesis, Characterization and Biological Screening of Ferulic Acid Derivatives. Journal of Cancer Therapy, 6, 917-931. doi: 10.4236/jct.2015.610100.

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