Exploration and Research on HIV/AIDS Patients’ Complement C1q Level Changes before and after Treatments

Guosheng Su^1,2,3, Xiaolu Luo^1,2,3*, Shunda Luo^1,2,3, Zeduan Liu^1,2,3, Zuyan Ni^1,2,3*, Wanhong Huang^1,2,3, Juanying Liang^1,2,3

¹The Fourth People’s Hospital Clinical Laboratory, Nanning, China.
²Guangxi Medical University Hospital for Infectious Diseases, Nanjing, China.
³Guangxi AIDS Clinical Treatment Center, Nanning, China.

DOI: 10.4236/aid.2015.53013                

Abstract

Objective: The study aimed to investigate the complement C1q test results of HIV/AIDS patients in clinical application before and after treatments. Methods: We collected HIV/AIDS patients’ serum specimens storing at -80 centigrade freezer in cryogenic refrigerator for standby. After samples quantity met the requirements of selected cases unified, complement C1q was detected by immune transmission turbidity method, and compared the differences in complement C1q of HIV/AIDS patients in test results before and after treatment. In the collection of 96 cases selected samples, concentration of complement C1q was 157.95 ± 31.46 mg/L before treatment, while after treatment, it was 147.26 ± 28.76 mg/L. Comparing the results before and after treatment, t = 2.45726, P = 0.01049, the difference was statistically significant. Concentration of complement C1q increased after treatment with 33 cases. There were 63 cases reducing. Through statistical analysis on the data from the number of reducing and increasing cases, chi-square = 18.75, P = 0.00356, the difference was statistically significant. Complement C1q detection in the treatment of patients with HIV/AIDS had an important clinical significance in the process. The analysis of the concentration changes before and after treatment was clinically significant for drug selection and monitoring disease progression and curative effects, which would be worth further researching.

Keywords

HIV, AIDS, Complement C1q, Immune Transmission Turbidity

Conflicts of Interest

The authors declare no conflicts of interest.

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