Isolated Tracheobronchial Amyloidosis


The tracheobronchial amyloidosis is a rarely localized form. It may manifest as a cancer. Only histological results allow diagnosis confirmation. A 68-year-old man was admitted for exploration of a low abundance hemoptysis. The chest radiograph was normal. CT scan objectified thickening of the walls of the trachea and bronchi which are the seat of calcifications. Bronchoscopy found a burgeoning infiltrative lesion training the right side face of the trachea and the anterior edge of the hull. Histological results confirmed tracheobronchial amyloidosis. Typing of this amyloidosis concluded to AL form. The study of amyloid extension lesion was negative. Immunoelectrophoresis of proteins in the blood and urine was normal. The patient was sent to receive external beam radiation to prepare for endoscopic surgical removal. Post-operative suites were marked by a complete resolution of clinical signs particularly hemoptysis with a follow-up of two years.

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Mahfoudhi, M. , Gorsane, I. , Turki, S. and Abdallah, T. (2015) Isolated Tracheobronchial Amyloidosis. International Journal of Clinical Medicine, 6, 643-645. doi: 10.4236/ijcm.2015.69085.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Georgiades, C.S., Neyman, E.G., Barish, M.A. and Fishman, E.K. (2004) Amyloidosis. A Review and CT Manifestations. Radiographics, 24, 405-416.
[2] Cazalets, C., Belleguic, C., Sost, G., Caulet-Maugendre, S., Kernec, J., Droz, D. and Grosbois, B. (2002) Tracheo-Bronchial Amyloidosis: Report of Two Cases. La Revue de Médecine Interne, 23, 317-321.
[3] Cazalets, C., Cadora, B., Mauduitb, N., Decaux, O., Ramée, M.-P., Le Pogamp, P., et al. (2003) Epidemiologic Description of Amyloidosis Diagnosed in University Hospital of Rennes from 1995 to 1999. La Revue de Médecine Interne, 24, 424-430.
[4] Racil, H., Ben Amar, J., Rouhou, S.C., Laaribi, G., Ayadi, A., Zarrouk, M., Chaouch, N. and Chabbou, A. (2011) Haemoptysis Revealing Tracheobronchial Amyloidosis. Revue de Pneumologie Clinique, 67, 109-112.
[5] Jiang, X. and Wang, G. (2012) On Primary Pulmonary Amyloidosis. European Journal of Radiology, 81, 1968.
[6] Brill, A.K., Woelke, K., Schädlich, R., Weinz, C. and Laier-Groeneveld, G. (2007) Tracheobronchial Amyloidosis—Bronchoscopic Diagnosis and Therapy of an Uncommon Disease: A Case Report. Journal of Physiology and Pharmacology, 58, 51-55.
[7] Yap, J.C., Wang, Y.T. and Poh, S.C. (1992) A Case of Primary Diffuse Tracheobronchial Amyloidosis Treated by Laser Therapy. Singapore Medical Journal, 33, 198-200.
[8] Hop, D.G. and Rasp, F.L. (1979) Spontaneous Regression of Tracheobronchial Amyloidosis. Chest, 76, 237-239.

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