Replace Psychometric Inferences with Direct Brain Measurements: LORETA Reflects Traditional Cerebral Loci for Neuropsychological Tests

DOI: 10.4236/nm.2015.63018   PDF   HTML   XML   4,468 Downloads   4,941 Views   Citations


Inferences of subtle cerebral injury and dysfunction have been historically dependent upon psychometric tests from which clinical neuropsychological profiles are generated. In addition to being secondary, over-inclusive and crude indicators of cerebral activity, psychometric tests are subject to economic incentives to “re-norm” traditional methods under the pretense of “ensuring” contemporary representations that are sanctioned by regulating organizations dominated by agendas of control over the interpretations of clinicians. The validity of neuropsychological tests is essential for their perspicacious application and interpretations. We measured the quantitative electroen-cephalographic profiles and calculated s-LORETA (standardized Low Resolution Electromagnetic Tomography) profiles in real time for normal men and women while they engaged in both traditional and novel neuropsychological tests that were employed to infer localized brain injury. Conspicuous alterations in source current density within specific frequency bands occurred within various regions of the right prefrontal region during performance of the Category, Design Fluency and Conditioned Spatial Association Test, the prefrontal medial surface during Toe Graphaesthesia, the caudal medial surface during Toe Gnosis, the left temporal region during Speech-Sounds, and within the right retrosplenial-parahippocampal region for Seashore Rhythms. Results supported the well established regional associations with the classic neuropsychological tests, verified the cerebral localization with more recent procedures, and emphasized the utility of modern real-time, direct cerebral imaging procedures.

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Corradini, P. and Persinger, M. (2015) Replace Psychometric Inferences with Direct Brain Measurements: LORETA Reflects Traditional Cerebral Loci for Neuropsychological Tests. Neuroscience and Medicine, 6, 107-115. doi: 10.4236/nm.2015.63018.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Collura, T.F. (2012) Individualized Assessment and Treatment Using Advanced EEG and Dynamic Localization Techniques with Live sLORETA. International Journal of Psychophysiology, 85, 285-290.
[2] Zakzanis, K.K., Mraz, R. and Graham, S.J. (2005) An fMRI Study of the Trail Making Test. Neuropsychologia, 43, 1878-1886.
[3] Adleman, N.E., Menon, V., Blasey, C.M., White, C.D., Warsofsky, I.S., Glover, G.H. and Reiss, A.L. (2002) A Developmental fMRI Study of the Stroop Color-Word Task. NeuroImage, 16, 61-75.
[4] Gruber, S.A., Rogowska, J., Holcomb, P., Soraci, S. and Yurgelun-Todd, D. (2002) Stroop Performance in Normal Control Subjects: An fMRI Study. NeuroImage, 16, 349-360.
[5] Persinger, M.A., Webster, D. and Tiller, S.G. (1998) SPECT (HMPAO) Support for Activation of the Medial Prefrontal Cortices during Toe Graphaesthesia. Perceptual and Motor Skills, 87, 59-63.
[6] Johnson, S.C., Saykin, A.J., Flashman, L.A., McAllister, T.W. and Sparling, M.B. (2001) Brain Activation on fMRI and Verbal Memory Ability: Functional Anatomical Correlates of CVLT Performance. Journal of International Neuropsychology Society, 7, 55-62.
[7] Pascual-Marqui, R.D. (2002) Standardized Low-Resolution Brain Electromagnetic Tomography (sLORETA): Technical Details. Methods and Findings in Experimental Clinical Pharmacology, 24, 5-12.
[8] Pascual-Marqui, R.D., Esslen, M., Kochi, K. and Lehmann, D. (2002) Functional Imaging with Low Resolution Brain Electromagnetic tomography (LORETA): A Review. Methods and Findings in Experimental Clinical Pharmacology, 24, 91-95.
[9] Mulert, C., Jäger, L., Schmitt, R., Bussfeld, P., Pogarell, O., Möller, H.J., Juckel, G. and Hegerla, U. (2004) Integration of fMRI and Simultaneous EEG: Towards a Comprehensive Understanding of Localization and Time-Course of Brain Activity in Target Detection. NeuroImage, 22, 83-94.
[10] Vitacco, D., Brandeis, D., Pascual-Marqui, R. and Martin, E. (2002). Correspondence of Event-related Potential Tomography and Functional Magnetic Resonance Imaging during Language Processing. Human Brain Mapping, 17, 4- 12.
[11] Dierks, T., Jelic, V., Pascual-Marqui, R.D., Wahlund, L.O., Julin, P., Linden, D.E.J., Maurer, K., Winblad, B. and Nordberg, A. (2000) Spatial Pattern of Cerebral Glucose Metabolism (PET) Correlates with Localization of Intracerebral EEG-Generators in Alzheimer’s Disease. Clinical Neurophysiology, 111, 1817-1824.
[12] Pizzagalli, D.A., Oakes, T.R., Fox, A.S., Chung, M.K., Larson, C.L., Abercrombie, H.C., Schaefer, S.M., Benca, R.M. and Davidson, R.J. (2004) Functional but Not Structural Subgenual Prefrontal Cortex Abnormalities in Melancholia. Molecular Psychiatry, 9, 393-405.
[13] Zumsteg, D., Wennberg, R.A., Treyer, V., Buck, A. and Wieser, H.G. (2005) H215O or 13NH3 PET and Electromagnetic Tomography (LORETA) during Partial Status Epilepticus. Neurology, 22, 1657-1660.
[14] Fisher, N.J., Deluca, J.W. and Rourke, B.P. (2007) Wisconsin Card Sorting Test and Halstead Category Test Performances of Children and Adolescents Who Exhibit the Syndrome of Nonverbal Learning Disabilities. Child Neuropsychology, 3, 61-70.
[15] Golden, C.J., Moses, J.A., Coffman, J.A., Miller, W.R. and Strider, F.D. (1983) Clinical Neuropsychology: Interface with Neurologic and Psychiatric Disorders. Grune and Stratton, New York.
[16] Lezak, M.D. (1983) Neuropsychological Assessment. 2nd Edition, Oxford University Press, New York.
[17] Bornstein, R.A. and Leason, M. (1984) Item Analysis of Halstead’s Speech-Sounds Perception Test: Quantitative and Qualitative Analysis of Errors. Journal of Clinical Neuropsychology, 6, 205-214.
[18] Reitan, R.M. and Wolfson, D. (1989) The Seashore Rhythm Test and Brain Functions. Clinical Neuropsychology, 3, 70-78.
[19] Jones-Gotman, M. and Milner, B. (1977) Design Fluency: The Invention of Nonsense Drawings after Focal Cortical Lesions. Neuropsychologia, 15, 653-674.
[20] Reitan, R.M. and Wolfson, D. (1993) The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. 2nd Edition, Neuropsychology Press, Tucson.
[21] Milner, B. (1982) Some Cognitive Effects of Frontal-lobe Lesions in Man. Philosophical Transactions of the Royal Society of London Biological Sciences, 289, 211-226.
[22] Reitan, R.M. and Wolfson, D. (1990) The Significance of the Speech-Sounds Perception Test for Cerebral Functions. Archives for Clinical Neuropsychology, 5, 265-272.
[23] Gilandas, A., Touyz, S., Beumont, P.J.V. and Greenberg, H.P. (1984) Handbook of Neuropsychological Assessment. Grune and Stratton, Sydney.
[24] Richards, P.M. and Persinger, M.A. (2004) Agility, Gnosis, and Graphaesthesia for the Toes and Fingers in Children: Normative Data (Ages 7-14). International Journal of Neuroscience, 114, 17-29.
[25] Knights, R.M. and Norwood, J.A. (1980) Revised Smoothed Normative Data on the Neuropsychological Test Battery for Children. Department of Psychology, Carleton University, Ottawa.
[26] Richards, P.M. and Persinger, M.A. (1992) Toe Graphaesthesia as a Discriminator of Brain Impairment: The Outstanding Feet for Neuropsychology. Perceptual and Motor Skills, 74, 1027-1030.
[27] Kolb, B. and Wishaw, I.Q. (1990) Fundamentals of Human Neuropsychology. W. H. Freeman and Company, New York.
[28] Hom, J. and Reitan, R.M. (1990) Generalized Cognitive Function After Stroke. Journal of Clinical and Experimental Neuropsychology, 12, 644-654.
[29] Halstead, W.C. (1947) Brain and Intelligence. University of Chicago Press, Chicago.
[30] Persinger, M.A. (1995) Neuropsychologica Brevita: An Application to Traumatic (Acquired) Brain Injury. Psychological Reports, 77, 702-724.

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