Serum Matrix Metalloproteinase 3 and  Tissue Inhibitor Metalloproteinase 1 in Vascular Dementia: A Comparative Study

Mohammed Zain Abdelwadoud Hussein

doi:10.4236/aar.2015.45016

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AAR> Vol.4 No.5, September 2015

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Serum Matrix Metalloproteinase 3 and Tissue Inhibitor Metalloproteinase 1 in Vascular Dementia: A Comparative Study ()

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DOI: 10.4236/aar.2015.45016 4,028 Downloads 4,404 Views

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Mohammed Zain Abdelwadoud Hussein

Affiliation(s)

Ain Shams University Hospital, Cairo, Egypt.

ABSTRACT

Aim: To compare serum level of matrix metalloproteinase 3 (MMP3) and tissue inhibitor metallo-proteinase 1 (TIMP1) in vascular dementia patients and healthy control subjects. Methods: A case control study was carried out in Ain Shams University hospital, Cairo, Egypt. 32 cases with vascular dementia were collected and classified into 2 subgroups; vascular dementia of multiinfarct type (VDMI) 14 patients, and vascular dementia of subcortical type (VDSC) 18 subjects. 23 cases with normal cognitive functions were collected as control group. Cases were subjected to comprehensive geriatric assessment, neurological examination, neuropsychological testing and brain CT scan. Blood sample was collected to analyze serum level of matrix metalloproteinase 3 (MMP3) and tissue inhibitor metalloproteinase 1 (TIMP1). Results: Mean serum level of TIMP1 (20.85 × 103 picogram/ml) was significantly lower than mean serum level of TIMP1 in control group (27.69 × 103 picogram/ml) (p = 0.018). The same finding was also evident when comparing VDMI subgroup mean serum TIMP1 (18.71 × 103 pc/ml) to control group (p = 0.025). There was no significant difference between mean serum MMP3 levels in cases group (mean = 67.39 × 103) as compared to control group (mean = 61.65 × 103 pc/ml) (p = 0.519). Conclusion: Patients with VD particularly VDMI has lower serum level of TIMP1 as compared to control group.

KEYWORDS

Multiinfarct Dementia, Matrix Metalloproteinase 3, Tissue Inhibitor Me, Talloproteinase 1, Vascular Dementia, Vascular Dementia of Subcortical Type

Cite this paper

Abdelwadoud Hussein, M. (2015) Serum Matrix Metalloproteinase 3 and Tissue Inhibitor Metalloproteinase 1 in Vascular Dementia: A Comparative Study. Advances in Aging Research, 4, 154-160. doi: 10.4236/aar.2015.45016.

Conflicts of Interest

The authors declare no conflicts of interest.

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