Hemopoietic Formulae Rearranged Leukocyte Subsets and Implication for Use against the Type of Constitution and Infectious Agent for Further Modification to Future
Nobuo Yamaguchi1,2*, Wataru Hiruma3, Kohei Suruga3, Nurmuhamamt Amat4, Dilxat Yimit4, Parida Hoxur4,5, Daisuke Sakamoto5, Kazuhiro Okamoto6, Shan-Yu Su7,8
1Department of Fundamental Research for CAM, Kanazawa Medical University, Ishikawa, Japan.
2Ishikawa Natural Medicinal Products Research Center, Ishikawa, Japan.
3International Operation Department (FM Center for R & D), Kibun Foods Inc., Tokyo, Japan.
4Traditional Uighur Medicine Department, Xinjiang Medical University, Urumchi, China.
5Traditional Chinese Medicine Hospital, Xinjiang Medical University, Urumchi, China.
6Department of Otolaryngology, Kanazawa Medical University, Ishikawa, Japan.
7Department of Chinese Medicine, China Medical University Hospital, Taiwan.
8School of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medicinal University, Taiwan.
DOI: 10.4236/oji.2015.53015   PDF   HTML   XML   3,523 Downloads   3,958 Views   Citations


A hemopoietic formula (HF) in traditional Chinese medicine (TCM) usually consists of more than six single herbs. We seek to look into changes of immune-competent cells by two commonly utilized HF, including Shi-Quan-Da-Bu-Tang (SDT) and Bu-Zong-Ye-Qi-Tang (BYT). However, the effects of both formulae on levels of leukocyte subsets are not yet defied. After administration of immno-suppressant to animals, the effects by HFs on the augmentation for subsets of leukocytes, CD positive cell counts of lymphocytes, and the cytokine-producing cells are measured. Our results show that SDT augments the level of lymphocytes, while BYT increases the level of granulocytes. In our clinical study with 15 healthy volunteers, positive cells for CD2, CD11b, CD14, IL-4, IL-1β and IFN-γ in peripheral blood are increased significantly 15 days after the ingestion of HFs. In rodents, compromised host as well as normal animal is administered with cancer chemotherapeutic agent (Mytomycin-C). Our observations show that SDT regulates phagocyte activities of the immune system, introducing it against intracellular parasite, and that BYT augments intercellular pathogen through humoral immunity. We discuss the significance and mechanism of HFs on the level of leukocyte subsets in number and function that are considered to be potential indicators for the evaluation of TCM modalities. We also propose an idea that TCM exhibits tonic effects via enhancing the ability to fight against infection and bacteria, as well as turning the multi-drug resistant bacteria to the sensitive ones. Together with these evidences, we suggest an ideal remedy for the compromised to fight host against pathogens. Moreover, we try to modify these hemopoietic formulae to more digestive forms. This modification brings to the significant lifted up for antibody producing cells and anti-oxidative activity for phagocytic cells.

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Yamaguchi, N. , Hiruma, W. , Suruga, K. , Amat, N. , Yimit, D. , Hoxur, P. , Sakamoto, D. , Okamoto, K. and Su, S. (2015) Hemopoietic Formulae Rearranged Leukocyte Subsets and Implication for Use against the Type of Constitution and Infectious Agent for Further Modification to Future. Open Journal of Immunology, 5, 183-198. doi: 10.4236/oji.2015.53015.

Conflicts of Interest

The authors declare no conflicts of interest.


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