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Prognosis of Breast Cancer Patients Underwent Surgery in a Developing Country

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DOI: 10.4236/jct.2015.69088    2,757 Downloads   3,423 Views   Citations

ABSTRACT

Background: We aim to review different factors associated with the relapse and the mortality in breast cancer patients in restricted-resource settings over a five-year period. Method: A retrospective cohort study including 133 women underwent breast cancer surgery was performed at the Surgical Oncology Unit of the Conakry University Hospital in Guinea. Socio-demographical characteristics, clinical information, treatment and data on relapse and survival were retrieved from medical files. Predictor factors of relapse were analyzed by using univariate and multivariate logistic regression. Factors associated with mortality were analyzed by Kaplan Meier survival and Cox models. Results: Breast cancer surgery was conservative in 13 cases (9.8%) and radical in 120 cases (90.2%). Five-year relapse was 33.8% ± 8.0% and the predictor factors of this relapse were age and stage III (p = 0.005). The overall 5-year mortality was 42.1% and the risk factors independently associated with death were body mass index (p = 0.01), origin of patients (p = 0.02), radiotherapy (p = 0.01) and cancer relapse (p = 0.001). Conclusion: The proportions of relapse and death were higher in breast cancer patients. The age and the stage of cancer at the time of surgery were the predictor factors of relapse. Body mass index, origin of patients, radiotherapy and cancer relapse were associated with death.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Traore, B. , Toure, A. , Sy, T. , Dieng, M. , Condé, M. , Deme, A. and Keita, N. (2015) Prognosis of Breast Cancer Patients Underwent Surgery in a Developing Country. Journal of Cancer Therapy, 6, 803-810. doi: 10.4236/jct.2015.69088.

References

[1] Ferlay, J., Soerjomataram, I., Dikshit, R., et al. (2014) Cancer Incidence and Mortality Worldwide: Sources, Methods and Major Patterns in GLOBOCAN 2012. International Journal of Cancer, 136, E359-E386.
[2] Ly, M., Antoine, M., André, F., et al. (2011) Breast Cancer in Sub-Saharan African Women: Review. Bulletin du Cancer, 98, 797-806.
[3] Amadori, D., Serra, P., Bravaccini, S., et al. (2014) Differences in Biological Features of Breast Cancer between Caucasian (Italian) and African (Tanzanian) Populations. Breast Cancer Research and Treatment, 145, 177-183.
http://dx.doi.org/10.1007/s10549-014-2903-0
[4] Morhason-Bello, I., Odedina, F., Rebbeck, T.R., et al. (2013) Challenges and Opportunities in Cancer Control in Africa: A Perspective from the African Organisation for Research and Training in Cancer. The Lancet Oncology, 14, e142-e151.
http://dx.doi.org/10.1016/s1470-2045(12)70482-5
[5] Globocan 2012. (2014) Estmated Cancer Incidence, Mortality and Prevalence Worldwide.
http://globocan.iarc.fr
[6] Traore, B., Barry Sonna, M., Dassy, E., et al. (2011) Over Review of Three Years (2007-2009) Activities of the Unit of Surgical Oncology, National Hospital of Donka. Guinée Médicale, 72, 11-18.
[7] Dickens, C., Joffe, M., Jacobson, J., et al. (2014) Stage at Breast Cancer Diagnosis and Distance from Diagnostic Hospital in a Periurban Setting: A South African Public Hospital Case Series of over 1000 Women. International Journal of Cancer, 135, 2173-2182.
http://dx.doi.org/10.1002/ijc.28861
[8] Abdulrahman Jr., G.O. and Rahman, G.A. (2012) Epidemiology of Breast Cancer in Europe and Africa. Journal of Cancer Epidemiology, 2012, Article ID: 915610.
http://dx.doi.org/10.1155/2012/915610
[9] Sankaranarayanan, R., Swaminathan, R., Brenner, H., et al. (2010) Cancer Survival in Africa, Asia, and Central America: A Population-Based Study. The Lancet Oncology, 11, 165-173.
http://dx.doi.org/10.1016/S1470-2045(09)70335-3
[10] Galukande, M., Wabinga, H. and Mirembe, F. (2015) Breast Cancer Survival Experiences at a Tertiary Hospital in Sub-Saharan Africa: A Cohort Study. World Journal of Surgical Oncology, 13, 220.
http://dx.doi.org/10.1186/s12957-015-0632-4
[11] Sobin, L.H., Gospodarowicz, M.K. and Wittekind, C. (2009) The TNM Classification of Malignant Tumors. 7th Edition, UICC.
[12] Fregene, A. and Newman, L.A. (2005) Breast Cancer in Sub-Saharan Africa: How Does It Relate to Breast Cancer in African-American Women? Cancer, 103, 1540-1550.
http://dx.doi.org/10.1002/cncr.20978
[13] López, M.A., Latiesas, X.S., Arnalot, P.F., Bassols, M.L., Castillejo, A.R., Jordana, J.Q., et al. (2007) Risk Factors of Local Relapse in Breast Cancer: The Importance of Age. Clinical and Translational Oncology, 9, 110-116.
http://dx.doi.org/10.1007/s12094-007-0021-8
[14] Wei, X.Q., Li, X., Xin, X.J., Tong, Z.-S. and Zhang, S. (2013) Clinical Features and Survival Analysis of Very Young (Age < 35) Breast Cancer Patients. Asian Pacific Journal of Cancer Prevention, 14, 5949-5952.
http://dx.doi.org/10.7314/APJCP.2013.14.10.5949
[15] Chauleur, C., Vulliez, L., Trombert, B., Raoux, D., Khaddage, A. and Seffert, P. (2008) Risk Factors for Tumor Recurrence after Breast Conserving Therapy: About 254 Cases. Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 37, 170-178.
http://dx.doi.org/10.1016/j.jgyn.2007.11.027
[16] Yu, K.D., Li, S. and Shao, Z.M. (2011) Different Annual Pattern Lumpectomy and Mastectomy: Implication for Breast Cancer Surveillance after Breast-Conserving Surgery. Oncologist, 16, 1101-1110.
http://dx.doi.org/10.1634/theoncologist.2010-0366
[17] Apffelstaedt, J.P. (2003) Locally Advanced Breast Cancer in Developing Countries: The Place of Surgery. World Journal of Surgery, 27, 917-920.
http://dx.doi.org/10.1007/s00268-003-6974-z
[18] Siponen, E.T., Joensuu, H. and Leidenius, M.H. (2013) Local Recurrence of Breast Cancer after Mastectomy and Modern Multidisciplinary Treatment. Acta Oncologica, 52, 66-72.
http://dx.doi.org/10.3109/0284186X.2012.718793
[19] Freedman, G.M. and Fowble Barbara, L. (2000) Local Recurrence after Mastectomy or Breast-Conserving Surgery and Radiation. Oncology, 14, 1561-1581.
[20] Cho, J.H., Park, J.M., Park, H.S., Park, S., Kim, S.I. and Park, B.-W. (2013) Oncologic Safety of Breast-Conserving Surgery Compared to Mastectomy in Patients Receiving Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer. Journal of Surgical Oncology, 108, 531-536.
http://dx.doi.org/10.1002/jso.23439
[21] Tovar, J.R., Zandonade, E. and Amorim, M.H. (2014) Factors Associated with the Incidence of Local Recurrences of Breast Cancer in Women Who Underwent Conservative Surgery. International Journal of Breast Cancer, 2014, Article ID: 639534.
http://dx.doi.org/10.1155/2014/639534
[22] But-Hadzic, J., Bilban-Jakopin, C. and Hadzic, V. (2010) The Role of Radiation Therapy in Locally Advanced Breast Cancer. The Breast Journal, 16, 183-188.
http://dx.doi.org/10.1111/j.1524-4741.2009.00885.x
[23] Wabinga, H., Parkin, D.M., Nambooze, S. and Amero, J. (2011) Cancer Survival in Kampala, Uganda, 1993-1997. IARC Scientific Publications, 162, 243-247.
[24] Al-Moundhri, M., Al-Bahrani, B., Pervez, I., Ganguly, S.S., Nirmala, V., Al-Madhani, A., et al. (2004) The Outcome of Treatment of Breast Cancer in a Developing Country—Oman. Breast, 13, 139-145.
http://dx.doi.org/10.1016/j.breast.2003.10.001
[25] Kantelhardt, E.J., Zerche, P., Mathewos, A., Trocchi, P., Addissie, A., Aynalem, A., et al. (2014) Breast Cancer Survival in Ethiopia: A Cohort Study of 1,070 Women. International Journal of Cancer, 135, 702-709.
http://dx.doi.org/10.1002/ijc.28691
[26] Ben Gobrane, H., Fakhfakh, R., Rahal, K., Ben Ayed, F., Maalej, M., Ben Abdallah, M., et al. (2007) Breast Cancer Prognosis in Salah Azaiez Institute of Cancer, Tunis. Eastern Mediterranean Health Journal, 13, 309-318.
[27] Gakwaya, A., Kigula-Mugambe, J.B., Kavuma, A., Luwaga, A., Fualal, J., Jombwe, J., et al. (2008) Cancer of the Breast: 5-Year Survival in a Tertiary Hospital in Uganda. British Journal of Cancer, 99, 63-67.
http://dx.doi.org/10.1038/sj.bjc.6604435
[28] Makanjuola, S.B., Popoola, A.O. and Oludara, M.A. (2014) Radiation Therapy: A Major Factor in the Five-Year Survival Analysis of Women with Breast Cancer in Lagos, Nigeria. Radiotherapy and Oncology, 111, 321-326.
http://dx.doi.org/10.1016/j.radonc.2014.03.013
[29] Ngowa, J.K.D., Kasia, J.M., Yomi J., Nana, A.N., Ngassam, A., Domkam, I., et al. (2015) Breast Cancer Survival in Cameroon: Analysis of a Cohort of 404 Patients at the Yaoundé General Hospital. Advances in Breast Cancer Research, 4, 44-52.
http://dx.doi.org/10.4236/abcr.2015.42005
[30] Chan, D.S., Vieira, A.R., Aune, D., Bandera, E.V., Greenwood, D.C., McTiernan, A., et al. (2014) Body Mass Index and Survival in Women with Breast Cancer-Systematic Literature Review and Meta-Analysis of 82 Follow-Up Studies. Annals of Oncology, 25, 1901-1914.
http://dx.doi.org/10.1093/annonc/mdu042
[31] Ogunleye, A.A. and Holmes, M.D. (2009) Physical Activity and Breast Cancer Survival. Breast Cancer Research, 11, 106.
http://dx.doi.org/10.1186/bcr2351
[32] Traoré, B., Keita, M., Diane, S., Dankoro, A., Kabba, I.S. and Keita, N. (2012) Clinicopathological Study of Breast Diseases Presenting to the Surgical Oncology Unit of Donka University Hospital in Conakry, Guinea. West African Journal of Medicine, 31, 227-231.
[33] Gombé Mbalawa, C., Diouf, D., NkouaMbon, J.B., Minga, B., Makouanzi Nsimba, S. and Nsondé Malanda, J. (2013) Arrival of Patients at Advanced Stage: Tempting to Identify Responsibility. Bulletin du Cancer, 100,167-172.

  
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