Management and Outcome of Pregnant Women with HIV Acquired by Vertical Transmission


The majority of children with perinatally acquired human immunodeficiency virus (HIV) do not survive beyond childhood but this is changing due to the benefit of antiretroviral therapy for the perinatally infected cohort, so affected children are now approaching the age to be mothers. The aim of this article is to evaluate the outcomes of pregnant women with HIV acquired by vertical transmission in our centre and encourage the results obtained in “Thirty Years Later: Pregnancies in Female Perinatally Infected with Human Immunodeficiency Virus-1”, a review article published in this journal in 2012 [2]. We report 6 patients with eight pregnancies with HIV acquired by vertical transmission. They delivered a total of nine newborns between 2004 and 2013. In any case, mother-to-child transmission was reported. The management of pregnant women with HIV acquired by vertical transmission is complicated, since the patients are the most of the cases young and the compliance to the treatment may be poor. The prematurity was the more frequent complication and the cesarean section was the more frequent form of ending. In our case series, mother-to-child transmission was absent.

Share and Cite:

Delgado, V. , Varea, A. , Valero, M. , Almela, V. , Montesinos, V. , Tejedor, A. and Marín, A. (2015) Management and Outcome of Pregnant Women with HIV Acquired by Vertical Transmission. Open Journal of Obstetrics and Gynecology, 5, 470-474. doi: 10.4236/ojog.2015.59068.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] WHO (2014) Data on the Size of the HIV/AIDS Epidemic: Data by WHO Region. World Health Organization, Geneva.
[2] Badell, M.L. and Lindsay, M. (2012) Thirty Years Later: Pregnancies in Females Perinatally Infected with Human Immunodeficiency Virus-1. AIDS Research and Treatment, 2012, Article ID: 418630, 6 p.
[3] Crane, S., Sullivan, M., Feingold, M. and Kaufman, G.E. (1998) Successful Pregnancy in an Adolescent with Perinatally Acquired Human Immunodeficiency Virus. Obstetrics & Gynecology, 92, 711.
[4] Williams, S.F., Keane-Tarchichi, M.H., Bettica, L., Dieudonne, A. and Bardeguez, A.D. (2008) Pregnancy Outcomes in Young Women with Perinatally Acquired Human Immunodeficiency Virus-1. American Journal of Obstetrics and Gynecology, 200, 149e1-149e5.
[5] Thorne, C., Townsend, C.L., Peckham, C.S., Newell, M.L. and Tookey, P.A. (2007) Pregnancies in Young Women with Vertically Acquired HIV Infection in Europe. AIDS, 21, 2552-2556.
[6] Beckerman, K., Giovanniello, A. and Wright, R. (2011) Retrospective Cohort Comparing Pregnancy Outcome among Perinatally Infected Women Compared to Sexually Infected. Proceedings of the IDSA Annual Meeting, Boston, 20-23 October 2011, 20-23.
[7] Townsend, C.L., Schulte, J., Thorne, C., et al. (2010) Antiretroviral Therapy and Preterm Delivery—A Pooled Analysis of Data from the United States and Europe. BJOG, 117, 1399-1410.
[8] Rudy, B.J., Murphy, D.A., Harris, D.R., Muenz, L. and Ellen, J. (2010) Prevalence and Interactions of Patient-Related Risks for Non-Adherence to Antiretroviral Therapy among Perinatally Infected Youth in the United States. AIDS Patient Care and STDs, 24, 97-104.
[9] Garcia-Tejedor, A., Maiques, V., Perales, A. and Lopez-Aldeguer, J. (2009) Influence of Highly Active Antiretroviral Treatment (HAART) on Risk Factors for Vertical HIV Transmission. Acta Obstetricia et Gynecologica Scandinavica, 88, 882-887.
[10] Maiques, V., Garcia-Tejedor, A., Diago, V., Molina, J.M., Borras, D., et al. (2010) Perioperative Cesarean Delivery Morbidity among HIV-Infected Women under Highly Active Antiretroviral Treatment: A Case-Control Study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 153, 27-31.

Copyright © 2022 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.