|
[1]
|
Ingram, D.K., Zhu, M., Mamczarz, J., Zou, S., Lane, M.A., Roth, G.S. and DeCabo, R. (2006) Calorie Restriction Mimetics: An Emerging Research Field. Aging Cell, 5, 97-108.
http://dx.doi.org/10.1111/j.1474-9726.2006.00202.x
|
|
|
[2]
|
Heilbronn, L.K. and Ravussin, E. (2003) Calorie Restriction and Aging: Review of the Literature and Implications for Studies in Humans. The American Journal of Clinical Nutrition, 78, 361-369.
|
|
|
[3]
|
Barger, J.L., Kayo, T., Vann, J.M., Arias, E.B., Wang, J., Hacker, T.A., Wang, Y., et al. (2008) A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice. PLoS ONE, 3, e2264.
http://dx.doi.org/10.1371/journal.pone.0002264
|
|
|
[4]
|
Lin, J.N., Lin, V., Rau, K.M., Shieh, P.C., Kuo, D.H., Shieh, J.C., Chen, W.J., et al. (2010) Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation. Journal of Agricultural and Food Chemistry, 58, 1584-1592.
http://dx.doi.org/10.1021/jf9035782
|
|
|
[5]
|
Thompson, H., Zhu, Z., Thompson, M., Jiang, W. and McGinley, J. (2011) Metformin as an Energy Restriction Mimetic Agent for Breast Cancer Prevention. Journal of Carcinogenesis, 10, 17.
http://dx.doi.org/10.4103/1477-3163.83043
|
|
|
[6]
|
Lane, M.A., Ingram, D.K. and Roth, G.S. (1998) 2-Deoxy-D-Glucose Feeding in Rats Mimics Physiologic Effects of Calorie Restriction. Journal of Anti-Aging Medicine, 1, 327-337.
http://dx.doi.org/10.1089/rej.1.1998.1.327
|
|
|
[7]
|
Zhu, Z., Jiang, W., McGinley, J.N. and Thompson, H.J. (2005) 2-Deoxyglucose as an Energy Restriction Mimetic Agent: Effects on Mammary Carcinogenesis and on Mammary Tumor Cell Growth in Vitro. Cancer Research, 65, 7023-7030.
http://dx.doi.org/10.1158/0008-5472.CAN-05-0453
|
|
|
[8]
|
Warburg, O., Wind, F. and Negelein, E. (1927) The Metabolism of Tumors in the Body. The Journal of General Physiology, 8, 519-530.
http://dx.doi.org/10.1085/jgp.8.6.519
|
|
|
[9]
|
Warburg, O. (1956) On the Origin of Cancer Cells. Science, 123, 309-314.
http://dx.doi.org/10.1126/science.123.3191.309
|
|
|
[10]
|
Woodward, G.E. and Carmer, F.B. (1952) 2-Deoxy-D-Glucose as an Inhibitor of Anaerobic Glycolysis in Tumor Tissues. Journal of the Franklin Institute, 254, 259-260.
http://dx.doi.org/10.1016/0016-0032(52)90482-1
|
|
|
[11]
|
Wan, R., Camandola, S. and Mattson, M.P. (2003) Intermittent Fasting and Dietary Supplementation with 2-Deoxy-D-Glucose Improve Functional and Metabolic Cardiovascular Risk Factors in Rats. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 17, 1133-1134.
http://dx.doi.org/10.1096/fj.02-0996fje
|
|
|
[12]
|
Wan, R., Camandola, S. and Mattson, M.P. (2004) Dietary Supplementation with 2-Deoxy-D-Glucose Improves Cardiovascular and Neuroendocrine Stress Adaptation in Rats. American Journal of Physiology-Heart and Circulatory Physiology, 287, H1186-H1193.
http://dx.doi.org/10.1152/ajpheart.00932.2003
|
|
|
[13]
|
Pelicano, H., Martin, D.S., Xu, R.H.H. and Huang, P. (2006) Glycolysis Inhibition for Anticancer Treatment. Oncogene, 25, 4633-4646.
http://dx.doi.org/10.1038/sj.onc.1209597
|
|
|
[14]
|
Dwarakanath, B. and Jain, V. (2009) Targeting Glucose Metabolism with 2-Deoxy-D-Glucose for Improving Cancer Therapy. Future Oncology, 5, 581-585.
http://dx.doi.org/10.2217/fon.09.44
|
|
|
[15]
|
Gupta, S., Farooque, A., Adhikari, J.S., Singh, S. and Dwarakanath, B.S. (2009) Enhancement of Radiation and Chemotherapeutic Drug Responses by 2-Deoxy-D-Glucose in Animal Tumors. Journal of Cancer Research and Therapeutics, 5, S16-S20.
http://dx.doi.org/10.4103/0973-1482.55135
|
|
|
[16]
|
Singh, D., Banerji, A.K., Dwarakanath, B.S., Tripathi, R.P., Gupta, J.P., Mathew, T.L., et al. (2005) Optimizing Cancer Radiotherapy with 2-Deoxy-D-Glucose: Dose Escalation Studies in Patients with Glioblastoma Multiforme. Strahlentherapie und Onkologie, 181, 507-514.
http://dx.doi.org/10.1007/s00066-005-1320-z
|
|
|
[17]
|
Pina, Y., Houston, S.K., Murray, T.G., Boutrid, H., Celdran, M., Feuer, W., Shi, W., et al. (2010) Focal, Periocular Delivery of 2-Deoxy-D-Glucose as Adjuvant to Chemotherapy for Treatment of Advanced Retinoblastoma. Investigative Ophthalmology and Visual Science, 51, 6149-6156.
http://dx.doi.org/10.1167/iovs.09-5033
|
|
|
[18]
|
Raez, L., Papadopoulos, K., Ricart, A., Chiorean, E., DiPaola, R., Stein, M., Lima, C., et al. (2012) A Phase I Dose-Escalation Trial of 2-Deoxy-D-Glucose Alone or Combined with Docetaxel in Patients with Advanced Solid Tumors. Cancer Chemotherapy and Pharmacology, 71, 523-530.
http://dx.doi.org/10.1007/s00280-012-2045-1
|
|
|
[19]
|
Farooque, A., Singh, N., Adhikari, J.S., Afrin, F. and Dwarakanath, B.S.R. (2014) Enhanced Antitumor Immunity Contributes to the Radio-Sensitization of Ehrlich Ascites Tumor by the Glycolytic Inhibitor 2-Deoxy-D-Glucose in Mice. PLoS ONE, 9, e108131.
http://dx.doi.org/10.1371/journal.pone.0108131
|
|
|
[20]
|
Stein, M., Lin, H., Jeyamohan, C., Dvorzhinski, D., Gounder, M., Bray, K., Eddy, S., et al. (2010) Targeting Tumor Metabolism with 2-Deoxyglucose in Patients with Castrate-Resistant Prostate Cancer and Advanced Malignancies. Prostate, 70, 1388-1394.
http://dx.doi.org/10.1002/pros.21172
|
|
|
[21]
|
Mohanti, B.K., Rath, G.K., Anantha, N., Kannan, V., Das, B.S., Chandramouli, B.A., Banerjee, A.K., et al. (1996) Improving Cancer Radiotherapy with 2-Deoxy-D-Glucose: Phase I/II Clinical Trials on Human Cerebral Gliomas. International Journal of Radiation Oncology, Biology, Physics, 35, 103-111.
http://dx.doi.org/10.1016/S0360-3016(96)85017-6
|
|
|
[22]
|
Dwarakanath, B.S., Singh, D., Banerji, A.K., Sarin, R., Venkataramana, N.K., Jalali, R., Vishwanath, P.N., et al. (2009) Clinical Studies for Improving Radiotherapy with 2-Deoxy-D-Glucose: Present Status and Future Prospects. Journal of Cancer Research and Therapeutics, 5, S21-S26.
http://dx.doi.org/10.4103/0973-1482.55136
|
|
|
[23]
|
Goldstein, D.S., Breier, A., Wolkowitz, O.M. and Pickar, D. (1992) Plasma Levels of Catecholamines and Corticotrophin during Acute Glucopenia Induced by 2-Deoxy-D-Glucose in Normal Man. Clinical Autonomic Research, 2, 359- 366.
http://dx.doi.org/10.1007/BF01831392
|
|
|
[24]
|
Lin, X., Zhang, F., Bradbury, C.M., Kaushal, A., Li, L., Spitz, D.R., Aft, R.L., et al. (2003) 2-Deoxy-D-Glucose-Induced Cytotoxicity and Radiosensitization in Tumor Cells is Mediated via Disruptions in Thiol Metabolism. Cancer Research, 63, 3413-3417.
|
|
|
[25]
|
Singh, S., Pandey, S., Bhatt, A.N., Chaudhary, R., Bhuria, V., Kalra, N., Soni, R., et al. (2015) Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich’s Ascites Tumor in Mice. PLoS ONE, 10, e0132089.
http://dx.doi.org/10.1371/journal.pone.0132089
|
|
|
[26]
|
Singh, S., Oberoi, R., Khanna, S., Bhatt, A., Saluja, D. and Dwarakanath, B. (2012) Energy Restriction Caused by the Glycolytic Inhibitor, 2-Deoxy-D-Glucose Inhibits Chemical Induced Carcinogenesis in Mice. Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research, Chicago, March 31-April 4 2012.
|
|
|
[27]
|
Stafstrom, C., Ockuly, J., Murphree, L., Valley, M., Roopra, A. and Sutula, T. (2009) Anticonvulsant and Antiepileptic Actions of 2-Deoxy-D-Glucose in Epilepsy Models. Annals of Neurology, 65, 435-447.
http://dx.doi.org/10.1002/ana.21603
|
|
|
[28]
|
Ockuly, J., Gielissen, J., Levenick, C., Zeal, C., Groble, K., Munsey, K., Sutula, T., et al. (2012) Behavioral, Cognitive, and Safety Profile of 2-Deoxy-2-Glucose (2DG) in Adult Rats. Epilepsy Research, 101, 246-252.
http://dx.doi.org/10.1016/j.eplepsyres.2012.04.012
|
|
|
[29]
|
Eikelis, N. and Buuse, V.M. (2000) Cardiovascular Responses to Open-Field Stress in Rats: Sex Differences and Effects of Gonadal Hormones. Stress, 3, 319-334.
http://dx.doi.org/10.3109/10253890009001137
|
|
|
[30]
|
Carola, V., D’Olimpio, F., Brunamonti, E. and Mangia, F. (2002) Evaluation of the Elevated Plus-Maze and Open-Field Tests for the Assessment of Anxiety-Related Behaviour in Inbred Mice. Behavioural Brain Research, 134, 49-57.
http://dx.doi.org/10.1016/S0166-4328(01)00452-1
|
|
|
[31]
|
Dawson, G.R. and Tricklebank, M.D. (1995) Use of the Elevated Plus Maze in the Search for Novel Anxiolytic Agents. Trends in Pharmacological Sciences, 16, 33-36.
http://dx.doi.org/10.1016/S0165-6147(00)88973-7
|
|
|
[32]
|
Porsolt, R.D., Pichon, L.M. and Jalfre, M.L. (1977) Depression: A New Animal Model Sensitive to Antidepressant Treatments. Nature, 266, 730-732.
http://dx.doi.org/10.1038/266730a0
|
|
|
[33]
|
Morris, R., Garrud, P., Rawlins, J. and O’Keefe, J. (1982) Place Navigation Impaired in Rats with Hippocampal Lesions. Nature, 297, 681-683.
http://dx.doi.org/10.1038/297681a0
|
|
|
[34]
|
Vorhees, C. and Williams, M. (2006) Morris Water Maze: Procedures for Assessing Spatial and Related Forms of Learning and Memory. Nature Protocols, 1, 848-858.
http://dx.doi.org/10.1038/nprot.2006.116
|
|
|
[35]
|
Ennaceur, A. and Delacour, J. (1988) A New One-Trial Test for Neurobiological Studies of Memory in Rats.1: Behavioral Data. Behavioural Brain Research, 37, 47-59.
http://dx.doi.org/10.1016/0166-4328(88)90157-X
|
|
|
[36]
|
Bevins, R.A. and Besheer, J. (2006) Object Recognition in Rats and Mice: A One-Trial Non-Matching-to-Sample Learning Task to Study Recognition Memory. Nature Protocols, 1, 1306-1311.
http://dx.doi.org/10.1038/nprot.2006.205
|
|
|
[37]
|
Kehl, L.J., Trempe, T.M. and Hargreaves, K.M. (2000) A New Animal Model for Assessing Mechanisms and Management of Muscle Hyperalgesia. Pain, 85, 333-343.
http://dx.doi.org/10.1016/S0304-3959(99)00282-1
|
|
|
[38]
|
Duan, W. and Mattson, M.P. (1999) Dietary Restriction and 2-Deoxyglucose Administration Improve Behavioral Outcome and Reduce Degeneration of Dopaminergic Neurons in Models of Parkinson’s Disease. Journal of Neuroscience Research, 57, 195-206.
http://dx.doi.org/10.1002/(SICI)1097-4547(19990715)57:2<195::AID-JNR5>3.0.CO;2-P
|
|
|
[39]
|
Yao, J., Chen, S., Mao, Z., Cadenas, E. and Brinton, R. (2011) 2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer’s Disease. PLoS ONE, 6, e21788.
http://dx.doi.org/10.1371/journal.pone.0021788
|
|
|
[40]
|
Wei, J., Cohen, D.M. and Quast, M.J. (2003) Effects of 2-Deoxy-D-Glucose on Focal Cerebral Ischemia in Hyperglycemic Rats. Journal of Cerebral Blood Flow and Metabolism, 23, 556-564.
http://dx.doi.org/10.1097/01.WCB.0000056061.18772.72
|
|
|
[41]
|
Levay, E.A., Govic, A., Penman, J., Paolini, A.G. and Kent, S. (2007) Effects of Adult-Onset Calorie Restriction on Anxiety-Like Behavior in Rats. Physiology and Behavior, 92, 889-896.
http://dx.doi.org/10.1016/j.physbeh.2007.06.018
|
|
|
[42]
|
Geng, Y.Q., Guan, J.T. and Xu, M.Y. (2007) Behavioral Study of Calorie-Restricted Rats from Early Old Age. Proceedings of the 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Lyon, 22-26 August 2007, 2393-2395.
http://dx.doi.org/10.1109/iembs.2007.4352809
|
|
|
[43]
|
Geng, Y., Li, T., Liu, X., Li, Z. and Fu, Y. (2011) SIRT1 and SIRT5 Activity Expression and Behavioral Responses to Calorie Restriction. Journal of Cellular Biochemistry, 112, 3755-3761.
http://dx.doi.org/10.1002/jcb.23315
|
|
|
[44]
|
Wadden, T.A. and Stunkard, A.J. (1986) Controlled Trial of Very Low Calorie Diet, Behavior Therapy, and Their Combination in the Treatment of Obesity. Journal of Consulting and Clinical Psychology, 54, 482-488.
http://dx.doi.org/10.1037/0022-006X.54.4.482
|
|
|
[45]
|
Jahng, J.W., Kim, J.G., Kim, H.J., Kim, B.T., Kang, D.W. and Lee, J.H. (2007) Chronic Food Restriction in Young Rats Results in Depression-and Anxiety-Like Behaviors with Decreased Expression of Serotonin Reuptake Transporter. Brain Research, 1150, 100-107.
http://dx.doi.org/10.1016/j.brainres.2007.02.080
|
|
|
[46]
|
Wooley, S.C. and Garner, D.M. (1991) Obesity Treatment: The High Cost of False Hope. Journal of the American Dietetic Association, 91, 1248-1251.
|
|
|
[47]
|
Bellush, L.L., Wright, A.M., Walker, J.P. and Kopchick, J. (1996) Caloric Restriction and Spatial Learning in Old Mice. Physiology and Behavior, 60, 541-547.
http://dx.doi.org/10.1016/S0031-9384(96)80029-1
|
|
|
[48]
|
Mamczarz, J., Bowker, J.L., Duffy, K., Zhu, M., Hagepanos, A. and Ingram, D.K. (2005) Enhancement of Amphetamine-Induced Locomotor Response in Rats on Different Regimens of Diet Restriction and 2-Deoxy-D-Glucose Treatment. Neuroscience, 131, 451-464.
http://dx.doi.org/10.1016/j.neuroscience.2004.11.019
|
|
|
[49]
|
Rosenzweig, E. and Barnes, C. (2003) Impact of Aging on Hippocampal Function: Plasticity, Network Dynamics, and Cognition. Progress in Neurobiology, 69, 143-179.
http://dx.doi.org/10.1016/S0301-0082(02)00126-0
|
|
|
[50]
|
Nehlig, A. and de Vasconcelos, A.P. (1993) Glucose and Ketone Body Utilization by the Brain of Neonatal Rats. Progress in Neurobiology, 40, 163-221.
http://dx.doi.org/10.1016/0301-0082(93)90022-K
|
|
|
[51]
|
Zhou, W., Mukherjee, P., Kiebish, M., Markis, W., Mantis, J. and Seyfried, T. (2007) The Calorically Restricted Ketogenic Diet, an Effective Alternative Therapy for Malignant Brain Cancer. Nutrition and Metabolism, 4, 5.
http://dx.doi.org/10.1186/1743-7075-4-5
|
|
|
[52]
|
Cao, D., Lu, H., Lewis, T. and Li, L. (2007) Intake of Sucrose-Sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease. Journal of Biological Chemistry, 282, 36275-36282.
http://dx.doi.org/10.1074/jbc.M703561200
|
|
|
[53]
|
Breier, A., Crane, A.M., Kennedy, C. and Sokoloff, L. (1993) The Effects of Pharmacologic Doses of 2-Deoxy-D-Glucose on Local Cerebral Blood Flow in the Awake, Unrestrained Rat. Brain Research, 618, 277-282.
http://dx.doi.org/10.1016/0006-8993(93)91276-X
|
|