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Efficacy and Safety of Axitinib as First-Line Therapy in Japanese Patients with Metastatic Renal Cell Carcinoma

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DOI: 10.4236/jct.2015.68074    2,567 Downloads   3,139 Views  

ABSTRACT

Previous study reported that patients treated with axitinib as second-line therapy had longer median progression-free survival than those treated with sorafenib for metastatic renal cell carcinoma (mRCC). In this study, we reviewed our experience of axitinib as a first-line therapy for mRCC in Japanese patients, focusing on its efficacy and safety. We retrospectively assessed 26 patients treated with axitinib as a first-line therapy for mRCC from July 2010 to July 2014 at Chiba Cancer Center and Kinki University Hospital. Observation period was 24.6 ± 18.3 months. The objective response rate was 50.0%, and the median progression-free survival was 27.5 months. Overall survival was not estimable. Common grade 3 adverse events were hypertension in 19 patients and proteinuria in 5 patients. Axitinib demonstrated significant efficacy as a first-line therapy in Japanese patients with mRCC. Careful monitoring and management of the adverse effects may help to control its toxicities.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Namekawa, T. , Fukasawa, S. , Komaru, A. , Kobayashi, M. , Ohzeki, T. , Sato, Y. , Rii, J. , Uemura, H. , Ichikawa, T. and Ueda, T. (2015) Efficacy and Safety of Axitinib as First-Line Therapy in Japanese Patients with Metastatic Renal Cell Carcinoma. Journal of Cancer Therapy, 6, 670-678. doi: 10.4236/jct.2015.68074.

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