Nano-Coupling of Cephalosporin Antibiotics with Fe3O4 Nanoparticles: Trojan Horse Approach in Antimicrobial Chemotherapy of Infections Caused by Klebsiella spp.

DOI: 10.4236/jbnb.2015.63021   PDF   HTML   XML   4,905 Downloads   5,692 Views   Citations


In the present study we had an aim to develop the methods of functionalizing the surface of magnetite nanoparticles with cefotaxime and ceftriaxone antibiotics. The quantitative analysis of the nanostructured cephalosporins was determined by Atom Absorbance Spectroscopy (AAS) and based on the Lambert-Beer law. The engineered nanostructures were tested on gram-negative microorganisms Klebsiella spp., of Enterobacteriaceae, and gram-positive bacteria Staphylococcus aureus, each having multi-drug resistance properties.

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Hasanova, U. , Ramazanov, M. , Maharramov, A. , Eyvazova, Q. , Agamaliyev, Z. , Parfyonova, Y. , Hajiyeva, S. , Hajiyeva, F. and Veliyeva, S. (2015) Nano-Coupling of Cephalosporin Antibiotics with Fe3O4 Nanoparticles: Trojan Horse Approach in Antimicrobial Chemotherapy of Infections Caused by Klebsiella spp.. Journal of Biomaterials and Nanobiotechnology, 6, 225-235. doi: 10.4236/jbnb.2015.63021.

Conflicts of Interest

The authors declare no conflicts of interest.


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