Leontiasis Ossea Following Secondary Hyperparathyroidism and Hemodialysis

DOI: 10.4236/jbm.2015.37006   PDF   HTML   XML   3,616 Downloads   4,232 Views   Citations

Abstract

Leontiasis ossea is a rare medical condition which is characterized by an overgrowth of the facial and cranial bones secondary to chronic renal failure and secondary hyperparathyroidism. We reported a case of leontiasis ossea with history of secondary hyperparathyroidism due to end-stage renal disease on regular hemodialysis. A 37-year-old female with end-stage renal disease from lupus disease on regular hemodialysis complaining of progressive facial deformity for two years causing dyspnea, dental malocclusion and dysarthria with the final diagnosis of uremic leontiasis ossea. It is important to recognize features of leontiasis ossea, as it may result in life-threatening upper airway obstruction and compressive cranial neuropathy while after parathyroidectomy, facial changes can be stabilized or improved mildly.

Share and Cite:

Dehghan, P. , Zahiri, A. , Karimi, M. and Ghadiani, M. (2015) Leontiasis Ossea Following Secondary Hyperparathyroidism and Hemodialysis. Journal of Biosciences and Medicines, 3, 54-59. doi: 10.4236/jbm.2015.37006.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Taskapan, H., Taskapan, C., Baysal, T., Sahin, I., Ulu, R., Karadag, N. and Kirimlioglu, V. (2004) Maxillary Brown Tumor and Uremic Leontiasis Ossea in a Patient with Chronic Renal Insufficiency. Clinical Nephrology, 61, 360-363.
http://dx.doi.org/10.5414/CNP61360
[2] Duan, S.Y., Xing, C.Y., Yang, G., Wang, N.N. and Zhang, B. (2014) Dramatic Alteration of the Skull in a Uremic Patient with Leontiasis Ossea. Internal Medicine, 53, 1971-1976.
http://dx.doi.org/10.2169/internalmedicine.53.2217
[3] Maramattom, B.V. (2006) Leontiasis Ossea and Post Traumatic Cervical Cord Contusion in Polyostotic Fibrous Dysplasia. Head & Face Medicine, 2, 24.
http://dx.doi.org/10.1186/1746-160X-2-24
[4] Lee, V.S., Webb Jr., M.S., Martinez, S., McKay, C.P. and Leight Jr., G.S. (1996) Uremic Leontiasis Ossea: “Bighead” Disease in Humans? Radiologic, Clinical and Pathologic Features. Radiology, 199, 233-240.
http://dx.doi.org/10.1148/radiology.199.1.8633151
[5] Bringhurst, F.R., Demay, M.B. and Kronenberg, H.M. (2003) Hormones and Disorders of Mineral Metabolism. In: Larsen, P.R., Kronenberg, H.M., Melmed, S., et al., Eds., Williams Textbook of Endocrinology, 10th Edition, Elsevier, Philadelphia, 1323-1324.
[6] Rosenberg, A.E. (2005) Bones, Joints and Soft Tissue Tumors. In: Kumar, V., Abbas, A.K. and Fausto, N., Eds., Robbins and Cotran Pathologic Basis of Disease, 7th Edition, Elsevier, Philadelphia, 1287-1288.
[7] Michiwaki, Y., Michi, K. and Yamaguchi, A. (1996) Marked Enlargement of the Jaws in Secondary Hyperparathyroidism: A Case Report. International Journal of Oral and Maxillofacial Surgery, 25, 54-56.
http://dx.doi.org/10.1016/S0901-5027(96)80012-9
[8] Chang, J.I., Som, P.M. and Lawson, W. (2007) Unique Imaging Findings in the Facial Bones of Renal Osteodystrophy. American Journal of Neuroradiology, 28, 608-609.
[9] Raisz, L.G., Kream, B.E. and Lorenzo, J.A. (2003) Metabolic Bone Disease. In: Larsen, P.R., Kronenberg, H.M., Melmed, S., et al., Eds., Williams Textbook of Endocrinology, 10th Edition, Elsevier, Philadelphia, 1395-1396.
[10] Kumar, S., Thuraisingham, R. and Yaqoob, M. (2006) Big-Head Disease: Uremic Leontiasis Ossea. Kidney International, 69, 1709.
http://dx.doi.org/10.1038/sj.ki.5001526
[11] Damm, D.D., Neville, B.W., McKenna, S., Jones, A.C., Freedman, P.D., Anderson, W.R. and Allen, C.M. (1997) Macrognathia of Renal Osteodystrophy in Dialysis Patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 83, 489-495.
http://dx.doi.org/10.1016/S1079-2104(97)90151-7
[12] Haroyan, H., Bos, A. and Ginat, D.T. (2015) Uremic Leontiasis Ossea. American Journal of Otolaryngology, 36, 74- 76.
http://dx.doi.org/10.1016/j.amjoto.2014.08.007

  
comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.