Varicose Veins, Retinal Tears and Deep Vein Thrombosis, New Insights into the Causes from Adams Disease

James David Adams Jr.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern Cali-fornia, Los Angeles, CA, USA.

DOI: 10.4236/ojapo.2015.43006                

Abstract

Adams disease is the consequence of overly active transient receptor potential cation channels (TRP). This case report presents a patient suffering from multiple vascular problems and may provide new insights into the causes of venous problems. Endothelial and smooth muscle cells in veins contain TRP. These channels when activated excessively result in calcium accumulation, oxygen radical formation and apoptosis of endothelial and smooth muscle cells. The death of critical cells in vein valves, may lead to varicose veins. The loss of endothelial cells in venules may lead to retinal tears. Damage to vein walls may lead to a deep vein thrombosis. Transient receptor potential cation channels may be new drug targets of interest in the treatment or prevention of these conditions.

Keywords

Transient Receptor Potential Cation Channels, Deep Vein Thrombosis, Varicose Veins, Retinal Tears, Adams Disease

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Adams, J. (2013) Editorial: Apoptosis Is Critical to Pain Control. Open Journal of Apoptosis, 2, 23-24. http://dx.doi.org/10.4236/ojapo.2013.23003
[2]	Adams, J. (2011) Adams Disease: Description and Management with Capsaicin and Heat. Open Complementary Medicine Journal, 3, 10-12. http://dx.doi.org/10.2174/1876391X01103010010
[3]	Yue, Z.C., Xie, J., Ye, A.S., Stock, J., Du, J.Y. and Yue, L.X. (2015) Role of TRP Channels in the Cardiovascular System. American Journal of Physiology Heart Circulatory Physiology, 308, H157-H182. http://dx.doi.org/10.1152/ajpheart.00457.2014
[4]	Liu, D.Y., Zhu, Z.M. and Tepel, M. (2008) The Role of Transient Receptor Potential Channels in Metabolic Syndrome. Hypertension Research, 31, 1989-1995. http://dx.doi.org/10.1291/hypres.31.1989
[5]	Sukumar, P., Sedo, A., Li, J., Wilson, L., O’Regan, D., Lippiat, J., Porter, K., Kearney, M., Ainscough, J. and Beech, D. (2012) Constitutively Active TRPC Channels of Adipocytes Confer a Mechanism for Sensing Dietary Fatty Acids and Regulating Adiponectin. Circulation Research, 111, 191-200. http://dx.doi.org/10.1161/CIRCRESAHA.112.270751
[6]	Beech, D. (2013) Characteristics of Transient Receptor Potential Canonical Calcium Permeable Channels and Their Relevance to Vascular Physiology and Disease. Circulation Journal, 77, 570-579. http://dx.doi.org/10.1253/circj.CJ-13-0154
[7]	Ding, Y.D., Fromel, T., Popp, R., Falck, J., Schunck, W. and Fleming, I. (2014) The Biological Actions of 11,12- Epoxyeicosatrienoic Acid in Endothelial Cells Are Specific to the R/S Enantiomer and Require G(s) Protein. Journal of Pharmacology and Experimental Therapeutics, 350, 14-21. http://dx.doi.org/10.1124/jpet.114.214254
[8]	Wilhelmsen, K., Kkakpour, S., Tran, A., Sheehan, K., Schumacher, M., Xu, F.Y. and Hellman, J. (2014) The Endocannabinoid/Endovanilloid N-Arachidonoyl Dopamine (NADA) and Synthetic Cannabinoid WIN55,212-2 Abate the Inflammatory Activation of Human Endothelial Cells. Journal of Biological Chemistry, 289, 13079-13100. http://dx.doi.org/10.1074/jbc.M113.536953
[9]	Zhu, Z.M., Luo, Z.D., Ma, S.T. and Liu, D.Y. (2011) TRP Channels and Their Implications in Metabolic Diseases. Pflugers Archives European Journal of Physiology, 461, 211-223. http://dx.doi.org/10.1007/s00424-010-0902-5