Effect of the Melatonin on Morning Blood Pressure Surge and Norepinephrine Endovenous Infusion in Healthy Volunteers


Melatonin, the pineal gland hormone, has been considered as a central hypotension factor. However their roles in the regulation of the human blood pressure and its possible use as antihyper-tensive drug have not been fully determined. The objective of this trial was to determine the effect of melatonin on blood pressure morning increase and a peripheral vasoconstriction challenge in healthy volunteers. Twelve healthy male volunteers were included in a prospective, comparative, randomized, crossover trial in which changes on blood pressure (BP) and heart rate (HR) after the first morning orthostatism and endovenous norepinephrine (NE) infusion were measured one hour after the administration of placebo (PL) or 10 mg of melatonin in double blind conditions. Melatonin blunted the effects of the first orthostatism on BP and HR. Melatonin also reduces the pressor effect of NA. One concludes that melatonin has central and peripheral hypotensive effects that support a potential role of this hormone in cardiovascular therapeutics.

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Carranza-Madrigal, J. , Cervantes-Alfaro, J. and López-Correa, S. (2015) Effect of the Melatonin on Morning Blood Pressure Surge and Norepinephrine Endovenous Infusion in Healthy Volunteers. International Journal of Clinical Medicine, 6, 458-464. doi: 10.4236/ijcm.2015.67060.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Zanoboni, A., Forni, A., Zanoboni-Muciaccia, W., et al. (1978) Effect of Pinealectomy on Arterial Blood Pressure and Food and Water Intake in the Rat. Journal of Endocrinological Investigation, 1, 125-130.
[2] Holmes, S.W. and Sugden, D. (1976) The Effect of Melatonin on Pinealectomy-Induced Hypertension in the Rat. British Journal of Pharmacology, 56, 360-361.
[3] Cagnacci, A., Arangino, S., Angiolucci, M., et al. (1998) Influences of Melatonin Administration on the Circulation of Women. American Journal of Physiology, 274, R335-R338.
[4] Arangino, S., Cagnacci, A., Angiolucci, M., et al. (1999) Effects of Melatonin on Vascular Reactivity, Catecholamine Levels, and Blood Pressure in Healthy Men. American Journal of Cardiology, 83, 1417-1419.
[5] Girouard, H., Denault, C., Chulak, C.H., et al. (2004) Treatment by N-Acetylcysteine and Melatonin Increase Cardiac Baroreflex and Improves Antioxidant Reserve. American Journal of Hypertension, 17, 947-954.
[6] Anwar, M.M., Meki, A.R. and Abu Rahma, H.H. (2001) Inhibitory Effects of Melatonin on Vascular Reactivity: Possible Role of Vasoactive Mediators. Comparative Biochemistry and Physiology Part C, 130, 357-367.
[7] Kikuya, M., Chonan, K., Imai, Y., Goto, E. and Masao, I. (2002) On Behalf of the Research Group. Accuracy and Reliability of Wrist-Cuff Devices for Self-Measurement of Blood Pressure. Journal of Hypertension, 20, 629-638.
[8] Paulis, L. and Simko, F. (2007) Blood Pressure Modulation and Cardiovascular Protection by Melatonin: Potential Mechanisms Behind. Physiological Research, 56, 671-684.
[9] Muller, J.E. (1999) Circadian Variation in Cardiovascular Events. American Journal of Hypertension, 12, 35S-42S.
[10] Panza, J.A., Epstein, S.E. and Quyyumi, A.A. (1991) Circadian Variation in Vascular Tone and Its Relation to Sympathetic Vasoconstrictor Activity. New England Journal of Medicine, 325, 986-990.
[11] Dodt, C., Breckling, U., Derad, I., et al. (1997) Plasma Epinephrine and Norepinephrine Concentrations of Healthy Humans Associated with Night Time Sleep and Morning Arousal. Hypertension, 30, 71-76.
[12] Cunnane, S.C., Manku, M.S., Oka, M. and Horrobin, D.F. (1980) Enhanced Vascular Reactivity to Various Vasoconstrictor Agents Following Pinealectomy in the Rat: Role of Melatonin. Canadian Journal of Physiology and Pharmacology, 58, 287-293.
[13] Laflamme, A.K., Wu, L., Foucart, S. and Champlain, J. (1998) Impaired Basal Sympathetic Tone and α1-Adrenergic Responsiveness in Association with the Hypotensive Effect of Melatonin in Spontaneously Hypertensive Rats. American Journal of Hypertension, 11, 219-229.
[14] Zhu, H.-Q., Cheng, X.-W., Xiao, L.-L., Jiang, Z.-K., Zhou, Q., Gui, S.-Y., Wei, W. and Wang, Y. (2008) Melatonin Prevents Oxidized Low-Density Lipoprotein-Induced Increase of Myosin Light Chain Kinase Activation and Expression in HUVEC through ERK/MAPK Signal Transduction. Journal of Pineal Research, 45, 328-334.
[15] Blask, D.E., Wilson, S.T. and Lemus-Wilson, A.M. (1994) The Oncostatic and Oncomodulatory Role of the Pineal Gland and Melatonin. Advances in Pineal Research, 7, 235-241.
[16] Pechanova, O., Matuskova, J., Capikova, D., et al. (2006) Effect of Spironolactone and Captopril on Nitric Oxide and S-Nitrosothiol Formation in Kidney of L-NAME-Treated Rats. Kidney International, 70, 170-176.
[17] Antón-Tay, F., Huerto-Delgadillo, L., Ortega-Corona, B. and Benitez-King, G. (1993) Melatonin Antagonism to Calmoduline May Modulate Multiple Cellular Functions. In: Toiutou, Y., Arendt, J. and Pévet, P., Eds., Melatonin and the Pineal Gland—From Basic Science to Clinical Application, Elsevier Science Publishers, Amsterdam, 41-46.
[18] Reiter, R.J., Tan, D.X. and Maldonado, M.D. (2005) Melatonin as an Antioxidant: Physiology versus Pharmacology. Journal of Pineal Research, 39, 215-216.

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