A Case of Relapsing Polychondritis Successfully Treated with Combination of a Glucocorticoid and Cyclosporine (Short Report)


Relapsing polychondritis is a rare cartilaginous inflammatory disease affecting the external ear, nose, peripheral joints and tracheobronchial tree. It is characterized by recurrent inflammation and degeneration of cartilage and connective tissue. A 72-year-old man complained of dyspnea, cough and wheezing for 2 months. Diffuse wall thickening and narrowing from the trachea to segmental bronchus were seen on chest CT. Tracheostomy was performed in order to avoid as-phyxia, and he was diagnosed as relapsing polychondritis on the basis of pathology evaluation of a tracheal biopsy specimen. He was treated with high doses of a glucocorticoid, with which his symptoms improved. However, the cough and wheezing recurred after tapering of the glucocorticoid. His symptoms thereafter were improved by combination of the glucocorticoid with cyclosporine. The immunosuppressive agent provided effective treatment for glucocorticoid-resistant relapsing polychondritis.

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Takahashi, K. , Inoue, H. , Sadamatsu, H. , Umeguchi, H. , Sueoka-Aragane, N. and Kimura, S. (2015) A Case of Relapsing Polychondritis Successfully Treated with Combination of a Glucocorticoid and Cyclosporine. International Journal of Clinical Medicine, 6, 439-443. doi: 10.4236/ijcm.2015.67057.

Conflicts of Interest

The authors declare no conflicts of interest.


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