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Disseminated Presentation of Primary Lymphoblastic Lymphoma of the Bone in a Pediatric Patient

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DOI: 10.4236/jct.2015.66058    2,523 Downloads   2,965 Views  

ABSTRACT

Primary non-Hodgkin’s lymphoma of the bone (PLB) is extremely rare in the pediatric population with less than 100 cases reported in the English literature. Most commonly, patients present with atraumatic bone pain and grossly normal radiographic findings. PLB is in the histopathological class of “small round cell tumors of bone”, as with most common bone tumors. The diagnosis is confirmed by immunohistochemical or flow cytometry based detection of tumor-specific proteins. We present a case of stage IV PLB of B-lymphoblastic type with an excellent response to chemotherapy to increase awareness among general pediatricians and pathologists about the importance of making the correct diagnosis, given the excellent prognosis for this disease.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Cao, L. , Sheikh, A. , Qing, X. , French, S. , Lasky, J. and Panosyan, E. (2015) Disseminated Presentation of Primary Lymphoblastic Lymphoma of the Bone in a Pediatric Patient. Journal of Cancer Therapy, 6, 536-542. doi: 10.4236/jct.2015.66058.

References

[1] Lones, M.A., Perkins, S.L., Sposto, R., Tedeschi, N., Kadin, M.E., Kjeldsberg, C.R., Wilson, J.F., Zwick, D.L. and Cairo, M.S. (2002) Non-Hodgkin’s Lymphoma Arising in Bone in Children and Adolescents Is Associated With an Excellent Outcome: A Children’s Cancer Group Report. Journal of Clinical Oncology, 20, 2293-2301.
http://dx.doi.org/10.1200/JCO.2002.06.017
[2] Fox, M.G., Marti, J.K., Bachmann, K.R., LeGallo, R.D. and Foster, W.C. (2015) Epiphyseal Presentation of Non-Hodgkin’s Lymphoma of Bone in Two Pediatric Patients—One with Primary Lymphoma of Bone. Skeletal Radiology, 44, 587-595.
http://dx.doi.org/10.1007/s00256-014-2010-7
[3] Arndt, C.A., Rose, P.S., Folpe, A.L. and Laack, N.N. (2012) Common Musculoskeletal Tumors of Childhood and Adolescence. Mayo Clinic Proceedings, 87, 475-487.
http://dx.doi.org/10.1016/j.mayocp.2012.01.015
[4] Bao, J. (2012) Young Males with Primary Lymphoma of Bone Presenting with Musculoskeletal Pain Are Prone to Be Misdiagnosed as Ankylosing Spondylitis: A Case Report. Rheumatology International, 32, 253-254.
http://dx.doi.org/10.1007/s00296-010-1776-8
[5] Hameed, M. (2007) Small Round Cell Tumors of Bone. Archives of Pathology and Laboratory Medicine, 131, 192-204.
[6] Termuhlen, A.M., Smith, L.M., Perkins, S.L., Lones, M., Finlay, J.L., Weinstein, H., Gross, T.G. and Abromowitch, M. (2012) Outcome of Newly Diagnosed Children and Adolescents with Localized Lymphoblastic Lymphoma Treated on Children’s Oncology Group Trial A5971: A Report from the Children’s Oncology Group. Pediatric Blood & Cancer, 59, 1229-1233.
http://dx.doi.org/10.1002/pbc.24149
[7] Termuhlen, A.M., Smith, L.M., Perkins, S.L., Lones, M., Finlay, J.L., Weinstein, H., Gross, T.G. and Abromowitch, M. (2013) Disseminated Lymphoblastic Lymphoma in Children and Adolescents: Results of the COG A5971 Trial: A Report from the Children’s Oncology Group. British Journal of Haematology, 162, 792-801.
http://dx.doi.org/10.1111/bjh.12460
[8] Messina, C. Ferreri, A.J., Govi, S., Bruno-Ventre, M., Gracia Medina, E.A., Porter, D., Radford, J., Heo, D.S., Park, H.Y., Pro, B., Jayamohan, J., Visco, C., Scarfo, L., Zucca, E., Gospodarowicz, M. and Christie, D., International Extranodal Lymphoma Study Group (IELSG) (2014) Clinical Features, Management and Prognosis of Multifocal Primary Bone Lymphoma: A Retrospective Study of the International Extranodal Lymphoma Study Group (the IELSG 14 study). British Journal of Haematology, 164, 834-840.
http://dx.doi.org/10.1111/bjh.12714
[9] Furman, W.L., Fitch, S., Hustu, H.O., Callihan, T. and Murphy, S.B. (1989) Primary Lymphoma of Bone in Children. Journal of Clinical Oncology, 7, 1275-1280.
[10] Cotterill, S.J., Ahrens, S., Paulussen, M., Jurgens, H.F., Voute, P.A., Gadner, H. and Craft, A.W. (2000) Prognostic Factors in Ewing’s Tumor of Bone: Analysis of 975 Patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group. Journal of Clinical Oncology, 18, 3108-3114.
[11] Li, Y., Du, Y., Luo, T.Y., Yang, H.F., Yu, J.H., Xu, X.X., Zheng, H.J. and Li, B. (2014) Factors Influencing Diagnostic Yield of CT-Guided Percutaneous Core Needle Biopsy for Bone Lesions. Clinical Radiology, 69, e43-e47.
http://dx.doi.org/10.1016/j.crad.2013.09.003
[12] Nouh, M.R. and Abu Shady, H.M. (2014) Initial CT-Guided Needle Biopsy of Extremity Skeletal Lesions: Diagnostic Performance and Experience of a Tertiary Musculoskeletal Center. European Journal of Radiology, 83, 360-365.
http://dx.doi.org/10.1016/j.ejrad.2013.10.012
[13] Reiter, A. (2007) Diagnosis and Treatment of Childhood Non-Hodgkin Lymphoma. Hematology, 2007, 285-296.
http://dx.doi.org/10.1182/asheducation-2007.1.285
[14] Aurias, A., Rimbaut, C., Buffe, C., Dubousset, J. and Mazabraud, A. (1983) Chromosomal Translocations in Ewing’s Sarcoma. New England Journal of Medicine, 309, 496-498.
http://dx.doi.org/10.1056/NEJM198308253090817
[15] Llombart-Bosch, A. and Navarro, S. (2001) Immunohistochemical Detection of EWS and FLI-1 Proteins in Ewing Sarcoma and Primitive Neuroectodermal Tumors: Comparative Analysis With CD99 (MIC-2) Expression. Applied Immunohistochemistry & Molecular Morphology, 9, 255-260.
http://dx.doi.org/10.1097/00129039-200109000-00010
[16] Krishnan, A., Shirkhoda, A., Tehranzadeh, J., Armin, A.R., Irwin, R. and Les, K. (2003) Primary Bone Lymphoma: Radiographic-MR Imaging Correlation. RadioGraphics, 23, 1371-1387.
http://dx.doi.org/10.1148/rg.236025056
[17] Scully, R.E., Mark, E.J. and McNeely, B.U. (1981) Case Records of the Massachusetts General Hospital. Weekly Clinicopathological Exercises. Case 36-1981. New England Journal of Medicine, 305, 567-574.
[18] Mulligan, M.E., McRae, G.A. and Murphey, M.D. (1999) Imaging Features of Primary Lymphoma of Bone. American Journal of Roentgenology, 173, 1691-1697.
http://dx.doi.org/10.2214/ajr.173.6.10584821
[19] Marina, V., Milena, R., Vesna, P., Sladana, P. and Vera, A. (2015) Complementary Roles of Bone Scintigraphy and MR Imaging in the Detection and Long-Term Follow-Up of Primary Non-Hodgkin’s Bone Lymphoma in a Child-Case Report. Skeletal Radiology, 44, 863-868.
http://dx.doi.org/10.1007/s00256-014-2067-3
[20] Spaepen, K., Stroobants, S., Dupont, P., Van Steenweghen, S., Thomas, J., Vandenberghe, P., Vanuytsel, L., Bormans, G., Balzarini, J., De Wolf-Peeters, C., Mortelmans, L. and Verhoef, G. (2001) Prognostic Value of Positron Emission Tomography (PET) with Fluorine-18 Fluorodeoxyglucose ([18F]FDG) after First-Line Chemotherapy in Non-Hodgkin’s Lymphoma: Is [18F]FDG-PET a Valid Alternative to Conventional Diagnostic Methods? Journal of Clinical Oncology, 19, 414-419.

  
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