Spanish Version of Test MIS (*) with Delayed Memory Recall Normative Values and Results in a Population with Mild Cognitive Impairment

Labos Edith¹, Trojanowski Sofía¹, Seinhart Daniel², Schapira Marcelo², Renato Alejandro¹

¹Laboratory of Cognitive Functions Research-Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
²Italian Hospital of Buenos Aires, Buenos Aires, Argentina.

DOI: 10.4236/aad.2015.42006                

Abstract

Background: Cognitive impairment becomes more common with ageing and may benefit from intervention. In a Spanish speaking population, detection of cognitive impairment by a general practitioner in Primary Care can be a problem, as many of the standard tests target English speaking populations. The Memory Impairment Screen (MIS-A) is a validated test using English words to detect Alzheimer’s Disease (AD) and other dementias. We have modified this test to suit a Spanish speaking population and added a new component, delayed recall. We have called our new test the Memory Impairment Screen with Delayed Recall (MIS-D). Objectives: 1) To test a Spanish version of MIS-A and MIS-D. 2) To assess the discriminative validity of MIS-D as a screening tool for the amnestic variant of Mild Cognitive Impairment (aMCI) in a group of Spanish speaking people aged 65 years old and over. Methods: A case-control study of a cohort of 739 native Spanish speaking residents of Buenos Aires aged 65 years old and over, of whom 436 were healthy controls and 303 had a diagnosis of aMCI. Measurements: Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NVP) were estimated for MIS-D and MIS-A. Results: Normative values for MIS-A and MIS-D were obtained from the control population. Both age and education significantly affected these values (p < 0.0001). Control participants showed significant differences for both modalities, MIS-A and MIS-D. The cut-off for MIS-A should be 7.5 and for MIS-D, 5.5. Comparison between control population and aMCI population using ROC curve gave a result of 5.5 in MIS-D, with 97% specificity and 76% sensitivity. Conclusion: MIS-D was positively predictive of aMCI, with 97% specificity and 76% sensitivity in a sample of Spanish speaking patients aged 65 years old and over in Buenos Aires.

Keywords

Amnestic Mild Cognitive Impairment, Memory Test, Delayed Recall

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Mitchell, A.J., Beaumont, H., Ferguson, D., Yadegarfar, M. and Stubbs, B. (2014) Risk of Dementia and Mild Cognitive Impairment in Older People with Subjective Memory Complaints: Meta-Analysis. Acta Psychiatrica Scandinavica, 130, 439-451. http://dx.doi.org/10.1111/acps.12336
[2]	Luengo-Fernandez R., Leal J. and Gray A. (2010) Dementia 2010: The Economic Burden of Dementia and Associated Research Funding in the United Kingdom. A Report Produced by the Health Economics Research Centre, University of Oxford for the Alzheimer’s Research.
[3]	Prince, M., Prina, M., Guerchet, M., et al. (2013) World Alzheimer Report. Dementia: A Public Health Priority. Alzheimer’s Disease International (ADI), London.
[4]	Prince, M., Prina, M., Guerchet, M., Albanese, E., et al. (2014) World Alzheimer Report: Dementia and Risk Reduction. Alzheimer’s Disease International (ADI), London.
[5]	Chan, M. (2015) Article Title. First WHO ministerial Conference on Global Action against Dementia. 16-17 March 2015, Geneva.
[6]	Prince, M., Bryce, R., Ferri, C. (2011) World Alzheimer Report 2011: The Benefits of Early Diagnosis and Intervention. Alzheimer’s Disease International (ADI), London.
[7]	Bond, J., Stave, C., Sganga, A., Vincenzino, O., O’connell, B. and Stanley, R.L. (2005) Inequalities in Dementia Care across Europe: Key Findings of the Facing Dementia Survey. International Journal of Clinical Practice, 59, 8-14. http://dx.doi.org/10.1111/j.1368-504X.2005.00480.x
[8]	Wilkinson, D., Stave, C., Keohane, D. and Vincenzino, O. (2004) The Role of General Practitioners in the Diagnosis and Treatment of Alzheimer’s Disease: A Multinational Survey. Journal of International Medical Research, 32, 149- 159. http://dx.doi.org/10.1177/147323000403200207
[9]	Pravat, K., Ritchiec, K. and Fodaled V. (2014) Anesthetics and Its Impact on the Brain and Alzheimer’s Disease. Journal of Alzheimer’s Disease, 39, 223-225.
[10]	Liu, Y., Pan, N., Ma, Y., Zhang, S., Guo, W., Li, H., Zhou, J., Liu, G. and Gao, M, (2013)Inhaled sevoflurane may promote progressionof amnestic mild cognitive impairment: A prospective,randomized parallel-group study. Am J Med Sci, 345, 355-360. http://dx.doi.org/10.1097/MAJ.0b013e31825a674d
[11]	Alzheimer Europe. National Dementia Plans: Finland. http://www.alzheimer-europe.org/EN/Policyin-Practice2/National-Dementia-Plans/Finland
[12]	(2011) UK Elder Care. In the Know E-Newsletter.
[13]	Dubois, B., Feldman, H.H., Jacova, C., Dekosky, S.T., Barberger-Gateau, P., Cummings, J., et al. (2007) Research Criteria for the Diagnosis of Alzheimer’s Disease: Revising the NINCDS-ADRDA Criteria. The Lancet Neurology, 6, 734-746. http://dx.doi.org/10.1016/S1474-4422(07)70178-3
[14]	Dubois, B., Feldman, H.H., Jacova, C., Cummings, J.L., Dekosky, S.T., Barberger-Gateau, P., et al. (2010) Revising the Definition of Alzheimer’s Disease: A New Lexicon. The Lancet Neurology, 9, 1118-1127. http://dx.doi.org/10.1016/S1474-4422(10)70223-4
[15]	Dubois, B. (2004) Amnesic MCI or Prodromal Alzheimer’s Disease? The Lancet Neurology, 3, 246-248. http://dx.doi.org/10.1016/S1474-4422(04)00710-0
[16]	Albert, M., et al. (2011) The Diagnosis of Mild Cognitive Impairment Due to Alzheimer’s Disease: Recommendations from the National Institute on Aging—Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 7, 270-279. http://dx.doi.org/10.1016/j.jalz.2011.03.008
[17]	Gautier, S., Reisberg, B., Zaudig, M., Petersen, R.C., Ritchie, K., Broich, K., et al. (2006) Mild Cognitive Impairment. The Lancet, 367, 1262-1270. http://dx.doi.org/10.1016/S0140-6736(06)68542-5
[18]	Dubois, B., Picard, G. and Sarazin, M. (2009) Dialogues in Clinical Neuroscience. Journal of Clinical Neuroscience, 11, 135- 139.
[19]	Tounsi, H., Deweer, B., Ergis, A.M., et al. (1999) Sensitivity to Semantic Cuing: An Index of Episodic Memory Dysfunction in Early Alzheimer Disease. Alzheimer Disease and Associated Disorders, 13, 38-46. http://dx.doi.org/10.1097/00002093-199903000-00006
[20]	Sarazin, M., Berr, C., De Rotrou, J. et al. (2007) Amnestic Syndrome of the Medial Temporal Type Identifies Prodromal AD: A Longitudinal Study. Neurology, 69, 1859-1867. http://dx.doi.org/10.1212/01.wnl.0000279336.36610.f7
[21]	Wagner, M., Wolf, S., Reischies, F.M., Daerr, M., Wolfsgruber S., Jessen F., et al. (2012) Biomarker Validation of a Cued Recall Memory Deficit in Prodromal Alzheimer Disease. Neurology, 78, 379- 386. http://dx.doi.org/10.1212/WNL.0b013e318245f447
[22]	Buschke, H. (1986) Cued Recall in Amnesia. Journal of Clinical and Experimental Neuropsycho- logy, 6, 433-440. http://dx.doi.org/10.1080/01688638408401233
[23]	Dubois, B. (2012) The New Criteria for Alzheimer Disease. ADI, London.
[24]	Villarejo, G.A. and Puertas-Martín, V. (2011) Utilidad de los test breves en el cribado de demencia. Neurology, 26, 425-433. http://dx.doi.org/10.1016/j.nrl.2010.12.002
[25]	Folstein, M.F., Folstein, S.E. and McHugh, P.R. (1975) Mini-Mental State: A Practical Method for Grading the Cognitive State of Patients for the Clinician. Journal of Psychiatric Research, 12, 189-198. http://dx.doi.org/10.1016/0022-3956(75)90026-6
[26]	Cullum, C.M., Thompson, L.L. and Smernoff, E.N. (1993) Three-Word Recall as a Measure of Memory. Journal of Clinical and Experimental Neuropsychology, 15, 321-329. http://dx.doi.org/10.1080/01688639308402566
[27]	Buschke, H., Sliwinski, M., Kuslansky, G. and Lipton, R.B. (1995) Aging, Encoding Specificity and Memory Changes in the Double Memory Test. Journal of the International Neuropsychological Society, 1, 483-493. http://dx.doi.org/10.1017/s1355617700000576
[28]	Buschke, H., Kuslansky, G., Katz, M., Stewart, W.F., Sliwinski, M.J., Eckholdt, H.M. and Lipton, R.B. (1999) Screening for Dementia with the Memory Impairment Screen. Neurology, 52, 231-238. http://dx.doi.org/10.1212/WNL.52.2.231
[29]	Tulving, E. and Thomson, D. (1973) Encoding Specificity and Retrieval Processes in Episodic Memory. Psychological Review, 80, 352-372. http://dx.doi.org/10.1037/h0020071
[30]	Gifford, D.R. and Cummings, J.L. (1999) Evaluating Dementia Screening Tests: Methodological Standards to Rate Their Performance. Neurology, 52,224-227. http://dx.doi.org/10.1212/WNL.52.2.224
[31]	Pérez-Martínez, D.A., Baztán, J.J., González-Becerra, M. and Socorro, A. (2005) Evaluación de la utilidad diagnóstica de una adaptación española del Buschke Memory Impairment Screen para detectar demencia y deterioro cognitivo. Revista de Neurología, 40, 644-648.
[32]	Barrero-Fernández, F.J, Vives-Montero, F. and Morales-Gordo, B. (2006) Evaluación de la versión española del MemoryImpairmentScreen. Revista de Neurología, 43, 15-19.
[33]	Böhm, P., Peña-Casanova, J., Gramunt , N., Manero, R.M., Terrón, C. and Quiñones-Ubeda, S. (2005) Versión española del MemoryImpairmentScreen (MIS): Datos normativos y validez discriminativa. Neurología, 20, 402-411.
[34]	Rojas, G., Serrano, C.M. and Allegri, R.F. (2008) Versión Argentina del Memory Impairment Screen (MIS) y Métodos de detección de demencias: Análisis comparativo de curvas ROC. Revista Neurológica Argentina, 33, 33-39.
[35]	Renato, A., Labos, E., Atlasovich, C. and Vanotti, S. (1996) Características de la producción de categorías semánticas en español rioplatense. En: Aires, B., Ed., Actas de las Jornadas Universitarias El lenguaje y sus alteraciones, Facultad de Medicina, Buenos Aires, 155-160.
[36]	Labos, E., Mauriño, A., Cristalli, D., Arguello, G., Seinhart, D., Etchepareborda, J., Cruz, D., Martinez, L. and Trojanowski, S. (2010) Versión adaptada en lengua hispana del Test MIS para hablantes sudamericanos. Estudio multicéntrico en la República Argentina. Resultados Preliminares. Alzheimer’s Association-International Conference, Honolulu, 21 July 2010, 21.
[37]	Sano, M., Raman, R., Emond, J., Thomas, R.G., Petersen, R., Schneider, L.S. and Aisen, P.S. (2011) Adding Delayed Recall to the Alzheimer Disease Assessment Scale Is Useful in Studies of Mild Cognitive Impairment but Not Alzheimer Disease. Alzheimer Disease and Associated Disorders, 25, 122-127. http://dx.doi.org/10.1097/wad.0b013e3181f883b7
[38]	Takayama, Y. (2010) A Delayed Recall Battery as a Sensitive Screening for Mild Cognitive Impairment: Follow-Up Study of Memory Clinic Patients after 10 years’. Journal of Medical and Dental Sciences, 57, 177-184
[39]	Gauthier, S., Dubois, B., Feldman, H. and Scheltens P. (2008) Revised Research Diagnostic Criteria for Alzheimer’s Disease. The Lancet Neurology, 7, 668-670. http://dx.doi.org/10.1016/S1474-4422(08)70146-7
[40]	Labos, E., Renato, A., Trojanowski, S., Seinhart, D., Camera, L. and Schapira, M. (2013) Comparing the Memory Impairment Screen (MIS)* Test with the Memory Impairment Screen Deferred (MISD) for Detection of Amnesic Mild Cognitive Impairment (aMCI). Proceedings of the Alzheimer’s Association International Conference, Boston, 13-18 July 2013, 21.
[41]	Petersen, R.C., Doody, R., Kurz, A., Mohs, R.C., Morris, J., Rabins, V., Ritchie, K., Rossor, M., Thal, L. and Winblad, B. (2001) Current Concepts in Mild Cognitive Impairment. Archives of Neurology, 58, 1985-1992. http://dx.doi.org/10.1001/archneur.58.12.1985
[42]	Robin, X., Turck, N., Hainard, A., Tiberti, N., Lisacek, F., Sanchez, J. and Markus, M. (2011) pROC: An Open-Source Package for R and S+ to Analyze and Compare ROC Curves. BMC Bioinformatics, 12, 77. http://dx.doi.org/10.1186/1471-2105-12-77
[43]	Revelle, W. (2009) An Introduction to Psychometric Theory with Applications in R. Springer. http://personality-project.org/r/book
[44]	Sekhon, J.S. (2011) Multivariate and Propensity Score Matching Software with Automated Balance Optimization. Journal of Statistical Software, 42, 1-52. http://www.jstatsoft.org/v42/i07/
[45]	Labos, E., Trojanowski, S. and Ruiz C. (2008) Prueba de recuerdo libre/facilitado con recuerdo inmediato. Versión Verbal de la FCSRT-IR. Adaptación y normas en lengua española. Revista Neurológica Argentina, 33, 50-66.
[46]	Van der Linden, M., Coyette, F., Pointrenaud, J., et al. (2004) L’Epreuve de Rappel Libre/ Rappel indicé á 16 Items’ (RL/RI-16). In: Van der Linden, M., Ed., L’Evaluation des troubles de la mémoire, Solal, Marseille.