Outflow Vessel in the Plane of Main Vortex of Large Cerebral Aneurysms: A Study of Hemodynamic Analyses

Hao Li; Tangming Peng; Jing Wu; Changren Huang; Yong Jiang; Ligang Chen

doi:10.4236/nm.2015.62012

Home > Journals > Medicine & Healthcare > NM

NM> Vol.6 No.2, June 2015

Share This Article:

Open Access

Outflow Vessel in the Plane of Main Vortex of Large Cerebral Aneurysms: A Study of Hemodynamic Analyses

Abstract Full-Text HTML XML

Download as PDF (Size:307KB) PP. 65-70

DOI: 10.4236/nm.2015.62012 3,780 Downloads 4,150 Views Citations

Author(s) Leave a comment

Hao Li¹, Tangming Peng¹, Jing Wu², Changren Huang¹, Yong Jiang¹, Ligang Chen^1*

Affiliation(s)

¹Department of Neurosurgery, The Affiliated Hospital of Luzhou Medical College, Luzhou, China.
²Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

ABSTRACT

Purpose: This study was designed to quantify and characterize the variations of hemodynamic parameters for those large cerebral aneurysms with outflow vessel in the plane of main vortex. Materials and Methods: A total of 19 consecutive patients with large cerebral aneurysms were constructed with the data of digital subtraction angiography. Those large cerebral aneurysms with outflow vessel in the plane of main vortex were included. Blood flow was hypothesized to be laminar and incompressible and blood Newtonian fluid. Computational fluid dynamics ICEM and Fluent software were used to simulate the computational hemodynamics of large cerebral aneurysms. Results: Hemodynamics parameters result of computational fluid dynamics showed that the velocity in the aneurysm neck, impact fields and the origin area of outflow vessels was obvious higher than that in the aneurysm sac and aneurysm dome. Wall shear stress was obvious higher in aneurysm neck, impact fields and the origin area of outflow vessels than that in the aneurysm sac and aneurysm dome. Conclusions: The location of outflow vessel played an impact on the level of blood flow within aneurysm sac for those large cerebral aneurysms with outflow vessel in the plane of main vortex.

KEYWORDS

Aneurysm, Hemodynamic, Outflow Vessel, Vortex

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Li, H. , Peng, T. , Wu, J. , Huang, C. , Jiang, Y. and Chen, L. (2015) Outflow Vessel in the Plane of Main Vortex of Large Cerebral Aneurysms: A Study of Hemodynamic Analyses. Neuroscience and Medicine, 6, 65-70. doi: 10.4236/nm.2015.62012.

References

[1]	Tateshima, S., Tanishita, K., Hakata, Y., et al. (2009) Alteration of Intraaneurysmal Hemodynamics by Placement of a Self-Expandable Stent. Laboratory investigation. Journal of Neurosurgery, 111, 22-27. http://dx.doi.org/10.3171/2009.2.JNS081324

[2]	Tremmel, M., Xiang, J., Natarajan, S.K., et al. (2010) Alteration of Intra-Aneurysmal Hemodynamics for Flow Diversion Using Enterprise and Vision Stents. World Neurosurgery, 74, 306-315. http://dx.doi.org/10.1016/j.wneu.2010.05.008

[3]	Hakimi, M., Knez, P., Lippert, M., et al. (2012) Altered In-Stent Hemodynamics May Cause Erroneous Upgrading of Moderate Carotid Artery Restenosis When Evaluated by Duplex Ultrasound. Journal of Vascular Surgery, 56, 1403-1408. http://dx.doi.org/10.1016/j.jvs.2012.03.035

[4]	Boussel, L., Rayz, V., McCulloch, C., et al. (2008) Aneurysm Growth Occurs at Region of Low Wall Shear Stress: Patient-Specific Correlation of Hemodynamics and Growth in a Longitudinal Study. Stroke, 39, 2997-3002. http://dx.doi.org/10.1161/STROKEAHA.108.521617

[5]	Pereira, V.M., Brina, O., Gonzalez, A.M., et al. (2013) Biology and Hemodynamics of Aneurismal Vasculopathies. European Journal of Radiology, 82, 1606-1617. http://dx.doi.org/10.1016/j.ejrad.2012.12.012

[6]	Meng, H., Tutino, V.M., Xiang, J., et al. (2014) High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis. AJNR American Journal of Neuroradiology, 35, 1254-1262. http://dx.doi.org/10.3174/ajnr.A3558

[7]	Huang, Q., Xu, J., Cheng, J., et al. (2013) Hemodynamic Changes by Flow Diverters in Rabbit Aneurysm Models: A Computational Fluid Dynamic Study Based on Micro-Computed Tomography Reconstruction. Stroke, 44, 1936-1941. http://dx.doi.org/10.1161/STROKEAHA.113.001202

[8]	Wu, C., Xu, B.N., Sun, Z.H., et al. (2012) Different Treatment Modalities of Fusiform Basilar Trunk Aneurysm: Study on Computational Hemodynamics. Chinese Medical Journal, 125, 97-101.

[9]	Takao, H., Murayama, Y., Otsuka, S., et al. (2012) Hemodynamic Differences between Unruptured and Ruptured Intracranial Aneurysms during Observation. Stroke, 43, 1436-1439. http://dx.doi.org/10.1161/STROKEAHA.111.640995

[10]	Zhang, Y., Mu, S., Chen, J., et al. (2011) Hemodynamic Analysis of Intracranial Aneurysms with Daughter Blebs. European Neurology, 66, 359-367. http://dx.doi.org/10.1159/000332814

[11]	Chien, A., Castro, M.A., Tateshima, S., Sayre, J., Cebral, J., et al. (2009) Quantitative Hemodynamic Analysis of Brain Aneurysms at Different Locations. American Journal of Neuroradiology, 30, 1507-1512. http://dx.doi.org/10.3174/ajnr.A1600

[12]	Liu, J., Xiang, J.P., Zhang, Y., Wang, Y., Li, H.Y., et al. (2014) Morphologic and Hemodynamic Analysis of Paraclinoid Aneurysms: Ruptured versus Unruptured. Journal of Neurointerventional Surgery, 6, 658-663. http://dx.doi.org/10.1136/neurintsurg-2013-010946

[13]	Duan, G.L., Lv, N., Yin, J.H., Xu, J.Y., Hong, B., et al. (2014) Morphological and Hemodynamic Analysis of Posterior Communicating Artery Aneurysms Prone to Rupture: A Matched Case-Control Study. Journal of Neurointerventional Surgery, 12, 456-460. http://dx.doi.org/10.1136/neurintsurg-2014-011450

[14]	Yan, L., Zhu, Y.-Q., Li, M.-H., Tan, H.-Q. and Cheng, Y.-S. (2013) Geometric, Hemodynamic, and Pathological Study of a Distal Internal Carotid Artery Aneurysm Model in Dogs. Stroke, 44, 2926-2929. http://dx.doi.org/10.1161/STROKEAHA.113.002290

[15]	Metaxa, E., Tremmel, M., Natarajan, S.K., Xiang, J.P., Paluch, R.A., et al. (2010) Characterization of Critical Hemodynamics Contributing to Aneurysmal Remodeling at the Basilar Terminus in a Rabbit Model. Stroke, 41, 1774-1782. http://dx.doi.org/10.1161/STROKEAHA.110.585992

[16]	Xu, J.Y., Yu, Y., Wu, X., Wu, Y.F., Jiang, C., et al. (2013) Morphological and Hemodynamic Analysis of Mirror Posterior Communicating Artery Aneurysms. PloS ONE, 8, e55413. http://dx.doi.org/10.1371/journal.pone.0055413

[17]	Kono, K., Fujimoto, T., Shintani, A. and Tomoaki, T. (2012) Hemodynamic Characteristics at the Rupture Site of Cerebral Aneurysms: A Case Study. Neurosurgery, 71, E1202-E1208. http://dx.doi.org/10.1227/NEU.0b013e31826f7ede

[18]	Backes, D., Vergouwen, M.D., Velthuis, B.K., van der Schaaf, I.C., Bor, A.S.E., et al. (2014) Difference in Aneurysm Characteristics between Ruptured and Unruptured Aneurysms in Patients with Multiple Intracranial Aneurysms. Stroke, 45, 1299-1303. http://dx.doi.org/10.1161/STROKEAHA.113.004421

[19]	Larrabide, I., Aguilar, M.L., Morales, H.G., Geers, A.J., Kulcsár, Z., et al. (2013) Intra-Aneurysmal Pressure and Flow Changes Induced by Flow Diverters: Relation to Aneurysm Size and Shape. American Journal of Neuroradiology, 34, 816-822. http://dx.doi.org/10.3174/ajnr.A3288

[20]	Xiang, J.P., Natarajan, S.K., Tremmel, M., Ma, D., Mocco, J., et al. (2011) Hemodynamic-Morphologic Discriminants for Intracranial Aneurysm Rupture. Stroke, 42, 144-152.