Purple Grape Juice, an Important Flavonoids Source, Influence in Biochemical Parameters in Offspring of Wistar Rats

Daniele Karina Hilger¹, Mariane Farias Wohlenberg¹, Thays Krischke Schaffer¹, Fernanda de Souza Machado¹, Luciana Kneib Gonçalves¹, Gabrielli Bortolato¹, Gabriele Dani², Adriana Rodrigues³, Cláudia Funchal¹, Caroline Dani¹

¹Centro Universitário Metodista-IPA, Porto Alegre, Brasil.
²Georgetown University, Washington DC, USA.
³Faculdade da Serra Gaúcha, Caxias do Sul, Brasil.

DOI: 10.4236/fns.2015.67071                

Abstract

Our objective was to evaluate the effect of chronic gestational treatment and post-breast feeding with purple grape juice on the biochemical parameters in offspring of dams. We used 40 male offspring from 14 Wistar rats which received purple grape juice or water by gavage daily for 42 days at a dose of 7 microliters/g. The offspring were divided into groups of water or juice. All received daily purple grape juice or water by gavage for 30 days after completion of their nursing period at a dose of 7 microliters/g. At the end of the treatment period, the offspring were euthanized by decapitation with its truncal blood collected and subsequently separated the serum from the blood. The measurements were performed by automation or by manual dosing. Considering the gestational factor, grape juice was able to reduce levels of total cholesterol, triglycerides, urea, alanine aminotransferase (ALT), and not alter the levels of creatinine and aspartate aminotransferase (AST) in serum of the offspring. When considering the post-breast feeding factor, grape juice resulted in an improvement in HDL-C. We concluded that purple grape juice was able to produce a beneficial effect on certain biochemical parameters in offspring.

Keywords

Vitis labrusca, Biochemical Profile, Pregnancy, Grape Juice

Conflicts of Interest

The authors declare no conflicts of interest.

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