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A Facile and Inexpensive Synthesis of 6-Ethynylbipyridine

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DOI: 10.4236/ijoc.2011.12006    5,730 Downloads   11,521 Views  


An inexpensive synthesis of 6-ethynylbipyridine has been accomplished using Sonogashira coupling of 2-bromo-6-iodopyridine with 2-methyl-3-butyn-2-ol. Subsequent Stille coupling with 2-(trimethylstannanyl) pyridine and hydrolysis provided the target compound in an overall high yield.

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The authors declare no conflicts of interest.

Cite this paper

J. Huo and J. Hoberg, "A Facile and Inexpensive Synthesis of 6-Ethynylbipyridine," International Journal of Organic Chemistry, Vol. 1 No. 2, 2011, pp. 33-36. doi: 10.4236/ijoc.2011.12006.


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