Key Plants in Fighting Cancer in the Middle East


This article is derived from a broader study of ethno-botany, medical anthropology and alternative medicine in Middle Eastern countries, which has been conducted during the past two decades. It presents examples of different edible and medicinal plants and their uses by different communities (urban, peasant and Bedouin) in the treatment of diseases and various medical disorders. Alongside, the article reviews current knowledge concerning plants and cancer prevention and treatment. The article shows that people of these countries use various parts of the plant in a host of manners-fresh and soft, cooked or dried, as both food and medicine. These plants—part of the natural fauna of the Middle Eastern countries—grow in the wild and are cultivated. The author found that the most significant plants used were in the following families: Compositae, Gramineae, Labiatae, Lamiaceae, Liliaceae, Malvaceae, Oleaceae, Ranunculaceae, Umbelliferae, and Urticaceae.

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Rabia, A. (2015) Key Plants in Fighting Cancer in the Middle East. Chinese Medicine, 6, 124-135. doi: 10.4236/cm.2015.62014.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Hitti, P. (1952) History of the Arabs, from the Earliest Times to the Present. Macmillan & Co. LTD, London.
[2] Ullmann, M. (1978) Islamic Surveys: Islamic Medicine. University Press, Edinburgh.
[3] Murad, A. (1966) Lamhat min tarikh al-tibb al-qadim = Glimpses from the History of Early Medicine. Maktabat al-Nasr al-Haditha, al-Qahira. (In Arabic)
[4] Al-Shatti, A. (1970) Al-‘Arab waal-tibb = The Arabs and Medicine. Manshurat Wazarat al-Thaqafa, Dimashq. (In Arabic)
[5] Al-Najjar, A. (1994) Fi Tarikh al-Ttib fi al-Dawlah al-lslamyya: History of Medicine in the Islamic Empire. Dar al-Ma’aref, Al-Qahira. (In Arabic)
[6] Hamarneh, S. (1991) Ibn al-Quff’s Contribution to Arab-Islamic Medical Sciences. Hamdard Medicines, 34, 27-36.
[7] Lev, E. (2002) Reconstructed material medica of the Medieval and Ottoman al-Sham. Journal of Ethnopharmacology, 80, 167-179.
[8] Lev, E. and Ammar, Z. (2000) Ethnopharmacological Survey of Traditional Drugs Sold in Israel at the End of the 20th Century. Journal of Ethnopharmacology, 72, 191-205.
[9] Ali-Shtayeh, M.S., Yaniv, Z. and Mahajna, J. (2000) Ethnobotanical Survey in the Palestinian Area: A Classification of the Healing Potential of Medicinal Plants. Journal of Ethnopharmacology, 73, 221-232.
[10] Palevitch, D. and Yaniv, Z. (2000) Medicinal Plants of the Holy Land. Modan Publishing House, Tel-Aviv, 104, 122, 205, 266-269.
[11] Abu-Rabia, A. (2005) Herbs as a Food and Medicine Source in Palestine. Asian Pacific Journal of Cancer Prevention, 6, 404-407.
[12] Abu-Rabia, A. (2014) Ethnobotany among Bedouin Tribes in the Middle East. In: Yaniv-Bachrach, Z. and Dudai, N., Eds., Medicinal and Aromatic Plants of the Middle East, Springer, Berlin, 27-36.
[13] World Cancer Research/American Association for Cancer Research (1997).
[14] Murray, M., Birdsall, T., Pizzorno, J. and Reilly, P. (2002) How to Prevent and Treat Cancer with Natural Medicine. The Berkley Publishing Group, New York, 3-23, 89-99, 165.
[15] Lipworth, L., Martínez, M.E., Angell, J., Hsieh, C.C. and Trichopoulos, D. (1997) Olive Oil and Human Cancer: An Assessment of the Evidence. Preventive Medicine, 26, 181-190.
[16] Sergio, L., Yolanda M., P., Beatriz, B., et al. (2004) Olive Oil and Cancer. Grasas y Aceites, 55, 33-41.
[17] Cohen, L.A. and Wynder, E.I. (1990) Do Dietary Monounsaturated Fatty Acids Play a Protective Role in Carcinogenesis and Cardiovascular Disease? Medical Hypotheses, 31, 83-89.
[18] Serra-Majem, L., La Vecchia, C., Ribas-Barba, L., et al. (1993) Changes in Diet and Mortality from Selected Cancers in Southern Mediterranean Countries, 1960-1989. European Journal of Clinical Nutrition, 47, S25-S34.
[19] Rose, D.P. and Connolly, J.M. (1992) Dietary Fat, Fatty Acids and Prostate Cancer. Lipids, 27, 798-803.
[20] Kushi, L.H., Lenart, E.B. and Willet, W. (1995) Health Implications of Mediterranean Diets in Light of Contemporary Knowledge. Meat, Wine, Fats and Oils. The American Journal of Clinical Nutrition, 61, 1416-1427.
[21] Buiati, E., Palli, D., Decarli, A., Amadori, D., Avellini, C. and Bianchi, S. (1989) A Case-Control Study of Gastric Cancer in Italy. International Journal of Cancer, 44, 611-616.
[22] Fortes, C., Forastiere, F., Anatra, F. and Schmid, G. (1995) Consumption of Olive Oil and Specific Groups in Relation to Breast Cancer Risk in Greece. Journal of the National Cancer Institute, 87, 1020-1021.
[23] Gonzalez, C.A., Torrent, M. and Agudo, A. (1990) Dietary Habits in Spain: An Approximation. Tumori, 76, 311-314.
[24] Bitterman, W.A., Farhadian, H., Abu Samra, C., Lerner, D., Amoun, H., Krapf, D. and Makov, UE. (1991) Environmental and Nutritional Factors Significantly Associated with Cancer of the Urinary Tract Among Different Ethnic Groups. The Urologic Clinics of North America, 18, 501-508.
[25] Ryde, D. (1984) What Should Humans Eat? Practitioner, 232, 415-418.
[26] Steinmetz, K. and Potter, J. (1996) Vegetables, Fruit, and Cancer Prevention. Journal of the Academy of Nutrition and Dietetic, 96, 1027-1039.
[27] Gilbar, O., Iron, G. and Goren, A. (2001) Adjustment to Illness of Cancer Patients Treated by Complementary Therapy along with Conventional Therapy. Patient Education & Counseling, 44, 243-249.
[28] Karim, F. and Qura’an, S. (1986) Medicinal Plants of Jordan. Yarmouk University, Irbid, 45, 68.
[29] Lust, J. (1980) The Herb Book. Bantam Books, Toronto & New York, 501-508.
[30] Krispil, N. (2000) Medicinal Plants in Israel and throughout the World: The Complete Guide. Hed Arzi Publishing House, Or Yehuda, 226, 239.
[31] Abu-Rabia, A. (2013) Fieldwork Notes and Interviews with Healers, 1993-2013.
[32] Ruan, W., Mao-de, L. and Zhou, J. (2006) Anticancer Effects of Chinese Herbal Medicine, Science or Myth? Journal of Zhejiang University SCIENCE B, 7, 1006-1014.
[33] Chatuevedi, N., Yadav, S. and Shukla, K. (2011) Diversified Therapeutic Potential of Avena Sativa: An Exhaustive Review. Asian Journal of Plant Science and Research, 1, 103-114.
[34] Slavin, J., Marquart, L. and Jacobs, D.J. (2000) Cereal Food World. 45, 54-58.
[35] Limer, J.L. and Speirs, V., (2004) Phyto-Oestrogens and Breast Cancer Chemoprevention. Breast Cancer Research, 6, 119-127.
[36] Guo, W., Nie, L., Wu, D., Wise, M., Collins, W., Meydani, S. and Meydani, M. (2010) Avenanthramides Inhibit Proliferation of Human Colon Cancer Cell Lines in Vitro. Nutrition and Cancer, 62, 1007-1016.
[37] Boulos, L. (1983) Medicinal Plants of North Africa. Reference Publications, Algonac, 110.
[38] Loizzo, M.R., Tundis, R., Menichini, F., et al., (2007) Cytotoxic Activity of Essential Oils from Labiatae and Lauraceae Families Against in Vitro Human Tumor Models. Anticancer Research, 27, 3293-3299.
[39] Sertel, S., Eichhorn, T., Plinkert, P.K. and Efferth, T. (2012) [Anticancer Activity of Saliva Officinalis Essential Oil against HNSCC Cell Line (UMSCC1)]. HNO, 59, 1203-1208.
[40] Ali-Shtayeh, M., Jamous, R. and Jamous, R. (2011) Herbal Preparation Use by Patients Suffering from Cancer in Palestine. Complementary Therapies in Clinical Practice, 17, 235-240.
[41] Dragan, S., Nicola, T., Ilina, R., et al. (2007) Role of Multi-Component Functional Foods in the Complex Treatment of Patients with Advanced Breast Cancer. Revista Medico-Chirurgicala a Societatii de Medici sI Naturalisti din Iasi, 111, 877-884.
[42] Duggan, C., Gannon, J. and Walker, W.A. (2002) Protective Nutrients and Functional Foods for the Gastrointestinal Tract. The American Journal of Clinical Nutrition, 75, 789-808.
[43] Charai, M., Mosaddak, M. and Faid, M. (1996) Chemical Composition and Antimicrobial Activities of Two Aromatic Plants: Origanum majorana L. and O. compactum Benth. Journal of Essential Oil Research, 8, 657-664.
[44] Vági, E., Simándi, B., Suhajda, á. and Héthelyi, é. (2005) Essential Oil Composition and Antimicrobial Activity of Origanum majorana L. Extracts Obtained with Ethyl Alcohol and Supercritical Carbon Dioxide. Food Research International, 38, 51-57.
[45] Dursun, E., Otles, S. and Akcicek, E. (2004) Herbs as a Food Source in Turkey. Asian Pacific Journal of Cancer Prevention, 5, 334-339.
[46] Deans, S. and Svoboda, K. (2006) The Antimicrobial Properties of Marjoram (Origanum majorana L.) Volatile Oil. Flavour and Fragrance Journal, 5, 187-190.
[47] Salveron, M. and Cantonia, M. (1989) Phillipine-Grown Cultivars of Allium cepa. Planta Medica, 55, 662.
[48] Vollerner, Y., Abdullaev, N., Gorovits, M. and Abubakkirov, N. (1983) Steroidal Saponins and Sapogenins of Allium XVIII. The Structure of Karatavioside B. Khimiya Prirodnykh Soedinii, 2, 197-201.
[49] Zaid, H., Rayan, A., Said, O. and Saad, B. (2010) Cancer Treatment by Greco-Arab and Islamic Herbal Medicine. The Open Nutraceuticals Journal, 3, 203-212.
[50] Ben-Arye, E., Schiff, E., Hassan, E., et al. (2011) Integrative Oncology in the Middle East: From Traditional Herbal Knowledge to Contemporary Cancer Care. Annals of Oncology, 23, 211-221.
[51] Challier, B., Perarnau, J.M. and Viel, J.F. (1998) Garlic, Onion and Cereal Fibre as Protective Factors for Breast Cancer: A French Case-Control Study. European Journal of Epidemiology, 14, 737-747.
[52] Millen, A.E., Subar, A.F., Graubard, B.I., et al. (2007) Fruit and Vegetable Intake and Prevalence of Colorectal Adenoma in a Cancer Screening Trial. The American Journal of Clinical Nutrition, 86, 1754-1764.
[53] Boeing, H., Jedrychowski, W., Wahrendorf, J., et al. (1991) Dietary Risk Factors in Intestinal and Diffuse Types of Stomach Cancer: A Multicenter Case-Control Study in Poland. Cancer Causes & Control, 2, 227-233.
[54] Grant, W.B. (2004) A Multicountry Ecologic Study of Risk and Risk Reduction Factors for Prostate Cancer Mortality. European Urology, 45, 271-279.
[55] Gonzalez , C.A., Pera, G., Agudo, A., et al. (2006) Fruit and Vegetable Intake and the Risk of Stomach and Oesophagus Adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). International Journal of Cancer, 118, 2559-2566.
[56] Galeone, C., Pelucchi, C., Dal Maso, L., et al. (2009) Allium Vegetables Intake and Endometrial Cancer Risk. Public Health Nutrition, 12, 1576-1579.
[57] Block, E., Saleem, A., Mahendra, J., Crecely, R., Apitz-Castro, R. and Cruz, M. (1984) The Chemistry of Alkyl Thiosulphate Esters. 8. (E,Z)-Ajoene: A Potent Antithrombotic Agent from Garlic. Journal of the American Chemical Society, 106, 8295-8296.
[58] Ghazanfar, S. and Al-Sabahi, A. (1993) Medicinal Plants of Northern and Central Oman. Economic Botany, 47, 89-98.
[59] McElnay, J.C. and Po, A.L.W. (1991) Dietary Supplements. 8. Garlic. Pharmaceutical Journal, 246, 324-326.
[60] Muller, B. (1990) Garlic (Allium sativum): Quantitative Analysis of the Tracer Substances Alliin and Allicin. Planta Medica, 56, 589-599.
[61] Abulafatih, H.A. (1987) Medicinal Plant of Southwestern Saudi Arabia. Economic Botany, 41, 354-360.
[62] Dirsch, V.M., Kiemer, A.K., Wagner, H. and Vollmar, A.M. (1988) The Effect of Allicin and Ajoene, Two Compounds of Garlic, on Inducible Nitric Oxide Synthase. Atherosclerosis, 139, 333-335.
[63] Singh, A. and Shukla, Y. (1998) Antitumor Activity of Diallyl Sulfide in Two-Stage Skin Model of Carcinogenesis. Biomedical and Environmental Sciences, 11, 258-263.
[64] Lipinski, B. and Egyud, L. (1992) Thiole Induced Cross-Linking of Human Blood Proteins: Implications for Tumor Immunity. Bioorganic & Medicinal Chemistry Letters, 2, 919-924.
[65] Abbas, J.A., El-Oqlah, A.A. and Mahasneh, A.M. (1992) Herbal Plants in the Traditional Medicine of Bahrain. Economic Botany, 46, 158-163.
[66] Gariboldi, P., Jommi, G. and Verotta, L. (1986) Two New Secoiridoids from Olea europaea. Phytochemistry, 25, 865-869.
[67] Ferro-Luzzi, A. and Sette, S. (1989) The Mediterranean Diet: An Attempt to Define Its Present and Past Composition. European Journal of Clinical Nutrition, 43, 13-29.
[68] Trichopoulou, A. (1992) Composition of Greek Foods and Dishes (in Greek and English). Athens School of Public Health, Athens.
[69] Martin-Moreno, J.M., Willet, W.C., Gorgojo, L., Banegas, J.R., Rodriguez-Artalejo, F., Fernandez-Rodriguez, J.C., Maisonneuve, P. and Boyle, P. (1994) Dietary Fat, Olive Oil Intake and Breast Cancer Risk. International Journal of Cancer, 58, 774-780.
[70] Trichopoulou, A., Katsouyanni, K., Stuver, S., Tzala, L., Gnardellis, C., Rimm, E. and Trichopoulous, D. (1995) Consumption of Olive Oil and Specific Food Groups in Relation to Breast Cancer Risk in Greece. Journal of the National Cancer Institute, 87, 110-116.
[71] Rose, D.P., Boyar, A.P. and Wynder, E.L. (1986) International Comparisons of Mortality Rates for Cancer of the Breast, Ovary, Prostate, and Colon and Per Capita Food Consumption. Cancer, 58, 1986, 2363-2371.<2363::AID-CNCR2820581102>3.0.CO;2-#
[72] Sieri, S., Krogh, V., Pala, V., Muti, P., Micheli, A., Evangelista, A., Tagliabue, G. and Berrino, F. (2004) Dietary Patterns and Risk of Breast Cancer in the ORDET Cohort. Cancer Epidemiology, Biomarkers & Prevention, 13, 567-572.
[73] Fortes, C., Forastiere, F., Farchi, S., Mallone, S., Trequattrinni, T., Anatra, F., Schmid, G. and Perucci, C.A. (2003) The Protective Effect of the Mediterranean Diet on Lung Cancer. Nutrition and Cancer, 46, 30-37.
[74] Passmore, R. and Eastwood, M.A. (1986) Fats. In: Passmore, R. and Eastwood, M.A., Eds., Davidson and Passmore: Human Nutrition and Dietetics, Churchill Livingstone, Edinburgh, 55-58.
[75] Attaur-Rehman, M., Sohail, M., Jon, C., et al. (1985) Isolation and Structure Determination of Nigellicine, a Novel Alkaloid from the Seeds of Nigella sativa. Tetrahedron Letters, 26, 2759-2762.
[76] al-Jawziyya, I.Q. (1998) Medicine of the Prophet. The Islamic Texts Society, Cambridge. (Translated and Edited by Penelope Johnstone)
[77] Shen, R.N., Lu, L., Jia, X.Q., Wong, M.L. and Kaiser, H.E. (1996) Naturin: A Potent Bio-Immunomodifier in Experimental Studies and Clinical Trials. In Vivo, 10, 201-209.
[78] El-Obeid, A., Al-Harbi, S., Al-Jomah, N. and Hassib, A. (2006) Herbal Melanin Modulates Tumor Necrosis Factor Alpha (TNF-Alpha), Interleukin 6 (IL-6) and Vascular Endothelial Growth Factor (VEGF) Production. Phytomedicine, 13, 324-333.
[79] Abuharfeil, N.M., Maraqa, A. and Von Kleist, S. (2000) Augmentation of Natural Killer Cell Activity in Vitro against Tumor Cells by Wild Plants from Jordan. Journal of Ethnopharmacology, 71, 55-63.
[80] Salim, E.I. and Fukushima, S. (2003) Chemo Preventive Potential of Volatile Oil from Black Cumin (Nigella sativa L.) Seeds against Rat Colon Carcinogenesis. Nutrition and Cancer, 45, 195-202.
[81] Potter, T. and Fagerson, I. (1990) Composition of Coriander Leaf Volatiles. Journal of Agriculture and Food Chemistry, 38, 2054-2056.
[82] Papai, et al. (2005) Encyclopedia of Agriculture and Food Systems. e-book, 473-481.
[83] Kizaibek, M., Kopp, B., Prinz, S., Popescu, R. and Upur, H. (2009) Antiproliferative Activity of Individual Herbs of Abnormal Savda Munziq on HL-60 Cells. Science & Technology Review, 19, 94-98.
[84] Konrad, L., Muller, H.H., Lenz, C., et al. (2000) Antiproliferative Effect on Human Prostate Cancer Cells by a Stinging Nettle Root (Urtica dioica) Extract. Planta Medica, 66, 44-47.
[85] Durak, I., Biri, H., Devrim, E., et al. (2004) Aqueous Extract of Urtica Dioica Makes Significant Inhibition on Adenosine Deaminase Activity in Prostate Tissue from Patients with Prostate Cancer. Cancer Biology & Therapy, 3, 855-857.
[86] Agus, H.H., Tekin, P., Bayav, M. and Semiz, A.S. (2009) A Drug Interaction Potential of the Seed Extract of Urtica urens L. (Dwarf Nettle). Phytotherapy Research, 23, 1763-1770.

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