The annual cycle of the pituitary-thyroid axis activity in healthy men under prolonged cold air exposure
Evgeny Bojko, Anastasiya Kaneva, Natalya Potolitsyna
DOI: 10.4236/jbise.2011.46058   PDF    HTML     4,446 Downloads   7,261 Views   Citations


The monthly investigations of military guards ((19.1 ? 0.9) years, n = 20) in northern European region (62?N lat.) that daily spent outdoors from 6 to 10 h were carried out during the year (from November to October). In examined subjects, the serum FT4 levels were high enough during all period of research espe-cially from April till October when the hormone levels exceeded norm. The concentration of serum FT3 was rather stable during the year and corresponded to the normal level. At the same time, the levels of total form of thyroid hormones (TT4 and TT3) displaced to lower limit of norm. Thus, staying outdoors of military guards in the North for all the year round is accompa-nied by activization of thyroid hormones use.

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Bojko, E. , Kaneva, A. and Potolitsyna, N. (2011) The annual cycle of the pituitary-thyroid axis activity in healthy men under prolonged cold air exposure. Journal of Biomedical Science and Engineering, 4, 462-471. doi: 10.4236/jbise.2011.46058.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Leblond, C.P. and Gross, J. (1943) Effect of thyroidecto-my on resistance to low environmental temperature. Endocrinology, 33, 155-160. doi:10.1210/endo-33-3-155
[2] Laurberg, P., Andersen, S. and Karmisholt, J. (2005) Cold adaptation and thyroid hormone metabolism. Hormone and Metabolic Research, 37, 545-549. doi:10.1055/s-2005-870420
[3] Silvestri, E., Schiavo, L., Lombardi, A. and Goglia, F. (2005) Thyroid hormones as molecular determinants of thermogenesis. Acta Physiologica Scandinavica, 184, 265- 283. doi:10.1111/j.1365-201X.2005.01463.x
[4] Leppaluoto, J., Korhonen, I., Huttunen, P. and Hassi, J. (1988) Serum levels of thyroid and adrenal hormones, tes-tosterone, TSH, LH, GH and prolactin in men after 2-h stay in a cold room. Acta Physiologica Scandinavica, 132, 543-548. doi:10.1111/j.1748-1716.1988.tb08363.x
[5] Thomas, J.R., Ahlers, S.T., House, J.F., Schrot, J., Van Orden, K.F., Winsborough, M.M., Hesslink, R.L.Jr. and Lewis, S.B. (1990) Adrenergic responses to cognitive ac-tivity in a cold environment. Journal of Applied Physiolo-gy, 68, 962-966.
[6] Leppaluoto, J., Paakonen, T., Korhonen, I. and Hassi, J. (2005) Pituitary and autonomic responses to cold expo-sures in man. Acta Physiologica Scandinavica, 184, 255- 264. doi:10.1111/j.1365-201X.2005.01464.x
[7] Leppaluoto, J., Lybeck, H., Virkkunen, P., Partanen, J. and Ranta, T. (1982) Effects of immersion in cold water on the plasma ACTH, GH, LH, and TSH concentrations in man. Circumpolar Health, 81, 601-602.
[8] Hesslink, R.L.Jr., D’Alessandro, M.M., Armstrong, D.W. and Reed, H.L. (1992) Human cold air habituation is in-dependent of thyroxine and thyrotropin. Journal of Ap-plied Physiology, 72, 2134-2139.
[9] Savourey, G., Caravel, J.P., Barnavol, B. and Bittel, J.H. (1994) Thyroid hormone changes in cold air environment after local cold acclimation. Journal of Applied Physiology, 76, 1963-1967.
[10] Nagata, H., Izumiyama, T., Kamata, K., Kono, S. and Yukimura, Y. (1976) An increase of plasma triiodothyro-nine concentration in man in cold environment. Journal of Clinical Endocrinology and Metabolism, 43, 1153-1156. doi:10.1210/jcem-43-5-1153
[11] Reed, H.L., Fereiro, J.A., Shakir, K.M., Burman, K.D. and O`Brain, J.T. (1988) Pituitary and peripheral hormone responses to T3 administration during Antarctic residence. American Journal of Physiology: Endocrinology and Me-tabolism, 254, E733-739.
[12] Reed, H.L., Reedy, K.R., Palinkas, L.A., Van Do, N., Finney, N.S., Case, H.S., LeMar, H.J., Wright, J. and Thomas, J. (2001) Impairment in cognitive and exercise performance during prolonced Antarctic residence effect of thyroxine supplementation in the polar triiodthyronine syndrome. Journal of Clinical Endocrinology and Meta-bolism, 86, 110-116. doi:10.1210/jc.86.1.110
[13] Harrop, J.S., Ashwell, K. and Hopton, M.R. (1985) Circanual and within-individual variation of thyroid function tests in normal subjects. Annals of Clinical Biochemistry, 22, 371-375.
[14] Hassi, J., Sikkila, K., Ruokohen, A. and Leppaluoto, J. (2001) The pituitary-thyroid axis in healthy men living under subarctic climatological conditions. Journal of En-docrinology, 169, 195-203. doi:10.1677/joe.0.1690195
[15] Leppaluoto, J., Sikkila, K. and Hassi, J. (1998) Seasonal variation of serum TSH and thyroid hormones in males living in Subarctic environmental conditions. International Journal of Circumpolar Health, 57, 383-385.
[16] Boiko, E.R. (1996) Realignment of human metabolism in the North. Human Physiology, 22, 496-502.
[17] Bojko, E.R. (1997) Metabolic changes induced by adapta-tion at 78 degrees North: Svalbard study. International Journal of Circumpolar Health, 56, 134-141.
[18] Boiko, E.R., Bichkaeva, F.A., Tkachev, A.V. and Dogadin, S.A. (1997) Regulation of metabolic reactions in various groups of aboriginal people of Polar Europe: an example of loading test with thyrotropin-releasing hormone. Human Physiology, 23, 469-471.
[19] Durnin, J.V. and Wommersley, I. (1974) Body fat as-sessed from total body density and its estimation from skinfold thickness measurements on 481 men and women aged from 16-72 years. British Journal of Nutrition, 32, 77-97. doi:10.1079/BJN19740060
[20] Reed, H.L. (1995) Circannual changes in thyroid hormone physiology: the role of cold environmental temperatures. Arctic Medical Research, 54, 9-15.
[21] Sawhney, R.C., Malhotra, A.S., Nair, C.S., Bajaj, A.C., Rajan, K.C., Pal, K., Prasad, R. and Basu, M. (1995) Thyroid function during a prolonged stay in Antarctica. European Journal of Applied Physiology and Occupational Physiology, 72, 127-133. doi:10.1007/BF00964127c
[22] Levine, M., Duffy, L., Moore, D.C. and Matej, L.A. (1995) Acclimation of non-indigenous sub-Arctic population: seasonal variation in thyroid function in interior Alaska. Comparative Biochemistry and Physiology. Part A: Comparative Physiology, 111, 209-214. doi:10.1016/0300-9629(95)00016-Z
[23] McCormack, P.D., Thomas, J., Malik, M. and Staschen, C.M. (1998) Cold stress, reverse T3 and lymphocyte function. Alaska Medicine, 40, 55-62.
[24] Fanjul, A.N. and Farias, R.N. (1993) Molecular intercon-version of cold-sensitive cytosolic 3,3’,5-tri-iodo-lthyronine- binding proteins from human erythrocytes: effect of cold, heat and pH treatments. Biochemical Journal, 290, 579- 582.
[25] Ribeiro, R.C., Cavalieri, R.R., Lomri, N., Rahmaouli, C.M., Baxter, J.D. and Scharschmidt, B.F. (1996) Thyroid hormone export regulates cellular hormone content and re-sponse. Journal of Biological Chemistry, 271, 17147- 17151. doi:10.1074/jbc.271.29.17147
[26] Leonard, W.R., Galloway, V.A., Ivakine, E., Osipova, L. and Kazakovtseva, M. (1999) Nutrition, thyroid function and basal metabolism of the Evenki of central Siberia. In-ternational Journal of Circumpolar Health, 58, 281-295.
[27] Nyrnes, A., Jorde, R. and Sundfjord, J. (2006) Serum TSH is possibly associated with BMI. International Journal of Obesity, 30, 100-105. doi:10.1038/sj.ijo.0803112

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