Research on Extraction Process of Gallic Acid from Penthorum chinense Pursh by Aqueous Ethanol


Penthorum chinense Pursh is rich in gallic acid, which has antioxidant, anti-inflammatory, anti-fungal and antitumor activities. In order to optimize their extraction conditions, various extraction parameters were chosen to identify their effects on gallic acid extraction. With extraction amount of gallic acid as index, based on single factor analysis, influence of solid/liquid ratio, ethanol concentration, fetch time and extraction temperature on extraction technology were investigated by orthogonal test. The optimization conditions for gallic acid extraction were determined as follows: ethanol concentration 60%, extraction time 2.5 h, temperature 90°C and solid/liquid ratio 1:30. The corresponding gallic acid content was 4.85%. This optimized extraction process was stable and feasible.

Share and Cite:

Kang, L. , Yang, S. , Peng, Y. , Dai, J. and Ying, X. (2015) Research on Extraction Process of Gallic Acid from Penthorum chinense Pursh by Aqueous Ethanol. Green and Sustainable Chemistry, 5, 63-69. doi: 10.4236/gsc.2015.52009.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Xiang, H., Yang, J., Fu, X., et al. (2013) Optimization of Extraction Technology of Penthorum chinense by Orthogonal Test. Chinese Journal of Experimental Traditional Medical Formulae, 19, 50-52.
[2] Chi, S.L., Zhuang, Y.C. and Shui, P.X. (2009) Progress on Penthorum chinense Pursh. Journal of Liaoning University of Traditional Chinese Medicine, 11, 61-64.
[3] Zhang, X. and Yang, M. (2002) Penthorum chinense Pursh Active Ingredients Research. Journal of Chengdu University of Traditional Chinese Medicine, 25, 46-51.
[4] Chen, H. and Li, G. (2009) Study on the Extraction Technology of Gallic Acid from Penthorum chinense by Method of Orthogonal Test Design. Journal of Sichuan of Traditional Chinese Medicine, 27, 56-57.
[5] Zhong, Y.T., Wang, X.L. and Ma, L.L. (2007) Studies on Antimicrobial of Liquidambar Taiwaniana Hance’s Leaf. Lishizhen Medicine and Materia Medica Research, 18, 1693-1694.
[6] Chen, H., Wang, H. and Yuan, H. (2010) Determination of Gallic Acid in Leaf of Liquidambar taiwaniana Hance in Different Areas by HPLC. Chinese Journal of Modern Applied Pharmacy, 27, 840-842.
[7] Lu, Q., Jiang, M.H., Jiang, J.G., et al. (2012) Isolation and Identification of Compounds from Penthorum chinense Pursh with Antioxidant and Antihepatocarcinoma Properties. Journal of Agricultural and Food Chemistry, 60, 11097- 11103.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.