Sorafenib after Arterial Chemoembolization in Child-Pugh A and B Cirrhotic Patients with Intermediate Hepatocellular Carcinoma: A Retrospective Analysis
Fernando Gomes Romeiro1*, Luciana Yumi Odani Sigahi2, Matheus Alvarez3, Fabio da Silva Yamashiro1, Fábio Cardoso de Carvalho1, Leonardo Pelafsky4, Talles Bazeia Lima1, Letícia de Campos Franzoni1, José Ricardo de Arruda Miranda3, Giovanni Faria Silva1
1Gastroenterology Division, Department of Internal Medicine, Faculdade de Medicina de Botucatu, UNESP—Univ Estadual Paulista, Sao Paulo, Brazil.
2Faculdade de Medicina de Botucatu, UNESP—Univ Estadual Paulista, Sao Paulo, Brazil.
3Department of Physics and Biophysics, Instituto de Biociências de Botucatu, UNESP—Univ Estadual Paulista, Sao Paulo, Brazil.
4Gastroenterology Division, Department of Surgery and Orthopedics, Faculdade de Medicina de Botucatu, UNESP—Univ Estadual Paulista, Sao Paulo, Brazil.
DOI: 10.4236/jct.2015.63031   PDF    HTML   XML   3,778 Downloads   4,490 Views   Citations


Introduction: Hepatocellular carcinoma (HCC) is a leading cause of mortality among cirrhotic patients, and current guidelines recommend single-treatment modalities according to patient and liver disease classifications. New studies have shown promising results from combining locoregional and systemic treatments, but most of them were limited to Child-Pugh A patients due to toxicity concerns. Aim: The objective of this study was to analyze survival rates of Child-Pugh A and B patients with intermediate HCC tumors treated with transarterial chemoembolization (TACE) followed by full-dose sorafenib usage. Material and methods: a retrospective analysis of 37 cirrhotic patients (Child-Pugh A and B rates = 23/14) treated with TACE and TACE followed by sorafenib usage (17 and 20 patients, respectively). Results: The mean survival was 379 days in the combined treatment group and 151 days in the single-treatment group (p = 0.007). There were no differences in survival according to the Child-Pugh classification. Conclusions: sorafenib after TACE can be an option for selected cirrhotic patients with intermediate HCC tumors if this combined approach is cautiously performed on an individualized schedule. Our results suggest that the Child-Pugh classification should not be a limitation to this combined treatment.

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Romeiro, F. , Sigahi, L. , Alvarez, M. , Yamashiro, F. , Carvalho, F. , Pelafsky, L. , Lima, T. , Franzoni, L. , Miranda, J. and Silva, G. (2015) Sorafenib after Arterial Chemoembolization in Child-Pugh A and B Cirrhotic Patients with Intermediate Hepatocellular Carcinoma: A Retrospective Analysis. Journal of Cancer Therapy, 6, 286-292. doi: 10.4236/jct.2015.63031.

Conflicts of Interest

The authors declare no conflicts of interest.


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