|
[1]
|
Stewart, B.W. and Kleihues, P. (2014) International Agency for Research on Cancer. World Cancer Report 351, Lyon.
|
|
[2]
|
Altieri, F., Grillo, C., Maceroni, M. and Chichiarelli, S. (2008) DNA Damage and Repair: From Molecular Mechanisms to Health Implications. Antioxidants & Redox Signaling, 10, 891-938.
http://dx.doi.org/10.1089/ars.2007.1830
|
|
[3]
|
Velingkar, V.S. and Dandekar, V.D. (2010) Modulation of P-Glycoprotein Mediated Multidrug Resistance (MDR) in Cancer Using Chemosensitizers. International Journal of Pharma Sciences and Research (IJPSR), 1, 104-111.
|
|
[4]
|
Shen, D., Pastan, I. and Gottesman, M.M. (1998) Cross-Resistance to Methotrexate and Metals in Human Cisplatin-Resistant Cell Lines Results from a Pleiotropic Defect in Accumulation of These Compounds Associated with Reduced Plasma Membrane Binding Proteins. Cancer Research, 58, 268-275.
|
|
[5]
|
Shen, D.W., Goldenberg, S., Pastan, I. and Gottesman, M.M. (2000) Decreased Accumulation of [14C]Carboplatin in Human Cisplatin-Resistant Cells Results from Reduced Energy-Dependent Uptake. Journal of Cellular Physiology, 183, 108-116.
http://dx.doi.org/10.1002/(SICI)1097-4652(200004)183:1<108::AID-JCP13>3.0.CO;2-4
|
|
[6]
|
Chai, S., To, K.K. and Lin, G. (2010) Circumvention of Multi-Drug Resistance of Cancer Cells by Chinese Herbal Medicines. Chinese Medicine, 5, 26.
http://dx.doi.org/10.1186/1749-8546-5-26
|
|
[7]
|
Jain, R.K. (2001) Delivery of Molecular and Cellular Medicine to Solid Tumors. Advanced Drug Delivery Reviews, 46, 149-168.
http://dx.doi.org/10.1016/S0169-409X(00)00131-9
|
|
[8]
|
Pluen, A., Boucher, Y., Ramanujan, S., McKee, T.D., Gohongi, T., di Tomaso, E., et al. (2001) Role of Tumor-Host Interactions in Interstitial Diffusion of Macromolecules: Cranial vs. Subcutaneous Tumors. Proceedings of the National Academy of Sciences of the United States of America, 98, 4628-4633.
http://dx.doi.org/10.1073/pnas.081626898
|
|
[9]
|
Schuetz, E.G., Beck, W.T. and Schuetz, J.D. (1996) Modulators and Substrates of P-Glycoprotein and Cytochrome P4503A Coordinately Up-Regulate These Proteins in Human Colon Carcinoma Cells. Molecular Pharmacology, 49, 311-318.
|
|
[10]
|
Jiang, H., Chen, K., He, J., Pan, F., Li, J., Chen, J.F., et al. (2009) Association of Pregnane X Receptor with Multidrug Resistance-Related Protein 3 and Its Role in Human Colon Cancer Chemoresistance. Journal of Gastrointestinal Surgery, 13, 1831-1838.
http://dx.doi.org/10.1007/s11605-009-0964-x
|
|
[11]
|
Lowe, S.W., Ruley, H.E., Jacks, T. and Housman, D.E. (1993) P53-Dependent Apoptosis Modulates the Cytotoxicity of Anticancer Agents. Cell, 74, 957-967.
http://dx.doi.org/10.1016/0092-8674(93)90719-7
|
|
[12]
|
Liu, Y.Y., Han, T.Y., Giuliano, A.E. and Cabot, M.C. (2001) Ceramide Glycosylation Potentiates Cellular Multidrug Resistance. FASEB Journal, 15, 719-730.
http://dx.doi.org/10.1096/fj.00-0223com
|
|
[13]
|
Fan, D., Beltran, P.J. and O’Brien, C.A., Eds. (1994) Reversal of Multidrug Resistance. CRC Press, Boca Raton.
|
|
[14]
|
Huang, G. and Chen, L. (2010) Recombinant Human Endostatin Improves Anti-Tumor Efficacy of Paclitaxel by Normalizing Tumor Vasculature in Lewis Lung Carcinoma. Journal of Cancer Research and Clinical Oncology, 136, 1201-1211.
http://dx.doi.org/10.1007/s00432-010-0770-6
|
|
[15]
|
Green, S.K., Frankel, A. and Kerbel, R.S. (1999) Adhesion-Dependent Multicellular Drug Resistance. Anti-Cancer Drug Design, 14, 153-168.
|
|
[16]
|
Durand, R.E. and Olive, P.L. (2001) Resistance of Tumor Cells to Chemo- and Radiotherapy Modulated by the Three-Dimensional Architecture of Solid Tumors and Spheroids. Methods in Cell Biology, 64, 211-233.
http://dx.doi.org/10.1016/S0091-679X(01)64015-9
|
|
[17]
|
Litman, T., Druley, T.E., Stein, W.D. and Bates, S.E. (2001) From MDR to MXR: New Understanding of Multidrug Resistance Systems, Their Properties and Clinical Significance. Cellular and Molecular Life Sciences CMLS, 58, 931-959.
http://dx.doi.org/10.1007/PL00000912
|
|
[18]
|
Dean, M., Hamon, Y. and Chimini, G. (2001) The Human ATP-Binding Cassette (ABC) Transporter Superfamily. Journal of Lipid Research, 42, 1007-1017.
|
|
[19]
|
Juliano, R.L. and Ling, V. (1976) A Surface Glycoprotein Modulating Drug Permeability in Chinese Hamster Ovary Cell Mutants. Biochimica et Biophysica Acta, 455, 152-162.
http://dx.doi.org/10.1016/0005-2736(76)90160-7
|
|
[20]
|
Ueda, K., Cardarelli, C., Gottesman, M.M. and Pastan, I. (1987) Expression of a Full-Length cDNA for the Human “MDR1” Gene Confers Resistance to Colchicine, Doxorubicin, and Vinblastine. Proceedings of the National Academy of Sciences of the United States of America, 84, 3004-3008.
http://dx.doi.org/10.1073/pnas.84.9.3004
|
|
[21]
|
Ambudkar, S.V., Dey, S., Hrycyna, C.A., Ramachandra, M., Pastan, I. and Gottesman, M.M. (1999) Biochemical, Cellular, and Pharmacological Aspects of the Multidrug Transporter. Annual Review of Pharmacology and Toxicology, 39, 361-398.
http://dx.doi.org/10.1146/annurev.pharmtox.39.1.361
|
|
[22]
|
Gottesman, M.M., Fojo, T. and Bates, S.E. (2002) Multidrug Resistance in Cancer: Role of ATP-Dependent Transporters. Nature Reviews Cancer, 2, 48-58.
http://dx.doi.org/10.1038/nrc706
|
|
[23]
|
Johnstone, R.W., Ruefli, A.A. and Smyth, M.J. (2000) Multiple Physiological Functions for Multidrug Transporter P-Glycoprotein? Trends in Biochemical Sciences, 25, 1-6.
http://dx.doi.org/10.1016/S0968-0004(99)01493-0
|
|
[24]
|
Sauna, Z.E. and Ambudkar, S.V. (2000) Evidence for a Requirement for ATP Hydrolysis at Two Distinct Steps during a Single Turnover of the Catalytic Cycle of Human P-Glycoprotein. Proceedings of the National Academy of Sciences of the United States of America, 97, 2515-2520.
http://dx.doi.org/10.1073/pnas.97.6.2515
|
|
[25]
|
Cole, S.P., Bhardwaj, G., Gerlach, J.H., Mackie, J.E., Grant, C.E., Almquist, K.C., et al. (1992) Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung-Cancer Cell-Line. Science, 258, 1650-1654.
http://dx.doi.org/10.1126/science.1360704
|
|
[26]
|
Jedlitschky, G., Leier, I., Buchholz, U., Barnouin, K., Kurz, G. and Keppler, D. (1996) Transport of Glutathione, Glucuronate, and Sulfate Conjugates by the MRP Gene-Encoded Conjugate Export Pump. Cancer Research, 56, 988-994.
|
|
[27]
|
Borst, P., Evers, R., Kool, M. and Wijnholds, J. (2000) A Family of Drug Transporters: The Multidrug Resistance-Associated Proteins. Journal of the National Cancer Institute, 92, 1295-1302.
http://dx.doi.org/10.1093/jnci/92.16.1295
|
|
[28]
|
Allikmets, R., Schriml, L.M., Hutchinson, A., Romano-Spica, V. and Dean, M. (1998) A Human Placenta-Specific ATP-Binding Cassette Gene (ABCP) on Chromosome 4q22 that Is Involved in Multidrug Resistance. Cancer Research, 58, 5337-5339.
|
|
[29]
|
Honjo, Y., Hrycyna, C.A., Yan, Q.W., Medina-Perez, W.Y., Robey, R.W., van de Laar, A., et al. (2001) Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-Overexpressing Cells. Cancer Research, 61, 6635-6639.
|
|
[30]
|
Komatani, H., Kotani, H., Hara, Y., Nakagawa, R., Matsumoto, M., Arakawa, H. and Nishimura, S. (2001) Identification of Breast Cancer Resistant Protein/Mitoxantrone Resistance/Placenta-Specific, ATP-Binding Cassette Transporter as a Transporter of NB-506 and J-107088, Topoisomerase I Inhibitors with an Indolocarbazole Structure. Cancer Research, 61, 2827-2832.
|
|
[31]
|
Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M.M., Pastan, I. and Willingham, M.C. (1987) Cellular Localization of the Multidrug-Resistance Gene Product P-Glycoprotein in Normal Human Tissues. Proceedings of the National Academy of Sciences of the United States of America, 84, 7735-7738.
http://dx.doi.org/10.1073/pnas.84.21.7735
|
|
[32]
|
Fletcher, J.I., Haber, M., Henderson, M.J. and Norris, M.D. (2010) ABC Transporters in Cancer: More than Just Drug Efflux Pumps. Nature Reviews Cancer, 10, 147-156.
http://dx.doi.org/10.1038/nrc2789
|
|
[33]
|
Schinkel, A.H., Wagenaar, E., Mol, C.A. and van Deemter, L. (1996) P-Glycoprotein in the Blood-Brain Barrier of Mice Influences the Brain Penetration and Pharmacological Activity of Many Drugs. Journal of Clinical Investigation, 97, 2517-2524.
http://dx.doi.org/10.1172/JCI118699
|
|
[34]
|
Cordon-Cardo, C., O’Brien, J.P., Boccia, J., Casals, D., Bertino, J.R. and Melamed, M.R. (1990) Expression of the Multidrug Resistance Gene Product (P-Glycoprotein) in Human Normal and Tumor Tissues. Journal of Histochemistry & Cytochemistry, 38, 1277-1287.
http://dx.doi.org/10.1177/38.9.1974900
|
|
[35]
|
Jonker, J.W., Smit, J.W., Brinkhuis, R.F., Maliepaard, M., Beijnen, J.H., Schellens, J.H.M. and Schinkel, A.H. (2000) Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan. Journal of the National Cancer Institute, 92, 1651-1656.
http://dx.doi.org/10.1093/jnci/92.20.1651
|
|
[36]
|
Maliepaard, M., Scheffer, G.L., Faneyte, I.F., van Gastelen, M.A., Pijnenborg, A.C., Schinkel, A.H., et al. (2001) Subcellular Localization and Distribution of the Breast Cancer Resistance Protein Transporter in Normal Human Tissues. Cancer Research, 61, 3458-3464.
|
|
[37]
|
St-Pierre, M.V., Serrano, M.A., Macias, R.I., Dubs, U., Hoechli, M., Lauper, U., et al. (2000) Expression of Members of the Multidrug Resistance Protein Family in Human Term Placenta. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 279, R1495-R1503.
|
|
[38]
|
Schinkel, A.H., Mayer, U., Wagenaar, E., Mol, C.A.A.M., van Deemter, L., Smit, J.J.M., et al. (1997) Normal Viability and Altered Pharmacokinetics in Mice Lacking Mdr1-Type (Drug-Transporting) P-Glycoproteins. Proceedings of the National Academy of Sciences of the United States of America, 94, 4028-4033.
http://dx.doi.org/10.1073/pnas.94.8.4028
|
|
[39]
|
Zhou, S.F., Lim, L.Y. and Chowbay, B. (2004) Herbal Modulation of P-Glycoprotein. Drug Metabolism Reviews, 36, 57-104.
http://dx.doi.org/10.1081/DMR-120028427
|
|
[40]
|
Evers, R., Zaman, G.J., Van Deemter, L., Jansen, H., Calafat, J., Oomen, L.C., et al. (1996) Basolateral Localization and Export Activity of the Human Multidrug Resistance-Associated Protein in Polarized Pig Kidney Cells. Journal of Clinical Investigation, 97, 1211-1218.
http://dx.doi.org/10.1172/JCI118535
|
|
[41]
|
Goldstein, L.J., Galski, H., Fojo, A., Willingham, M., Lai, S.L., Gazdar, A., et al. (1989) Expression of Multidrug Resistance Gene in Human Cancers. Journal of the National Cancer Institute, 81, 116-124.
http://dx.doi.org/10.1093/jnci/81.2.116
|
|
[42]
|
Dorr, R., Karanes, C., Spier, C., Grogan, T., Greer, J., Moore, J., et al. (2001) Phase I/II Study of the P-Glycoprotein Modulator PSC 833 in Patients with Acute Myeloid Leukemia. Journal of Clinical Oncology, 19, 1589-1599.
|
|
[43]
|
Leith, C.P., Kopecky, K.J., Chen, I.M., et al. (1999) Frequency and Clinical Significance of the Expression of the Multidrug Resistance Proteins MDR1/P-Glycoprotein, MRP1, and LRP in Acute Myeloid Leukemia: A Southwest Oncology Group Study. Blood, 94, 1086-1099.
|
|
[44]
|
Michieli, M., Damiani, D., Ermacora, A., Masolini, P., Raspadori, D., Visani, G., et al. (1999) P-Glycoprotein, Lung Resistance-Related Protein and Multidrug Resistance Associated Protein in de novo Acute Non-Lymphocytic Leukaemias: Biological and Clinical Implications. British Journal of Haematology, 104, 328-335.
http://dx.doi.org/10.1046/j.1365-2141.1999.01172.x
|
|
[45]
|
Tidefelt, U., Liliemark, J., Gruber, A., Liliemark, E., Sundman-Engberg, B., Juliusson, G., et al. (2000) P-Glycoprotein Inhibitor Valspodar (PSC 833) Increases the Intracellular Concentrations of Daunorubicin in Vivo in Patients with P-Glycoprotein-Positive Acute Myeloid Leukemia. Journal of Clinical Oncology, 18, 1837-1844.
|
|
[46]
|
El-Sharnouby, J.A., Abou El-Enein, A.M., El Ghannam, D.M., El-Shanshory, M.R., Hagag, A.A., Yahia, S. and Elashry, R. (2010) Expression of Lung Resistance Protein and Multidrug Resistance-Related Protein (MRP1) in Pediatric Acute Lymphoblastic Leukemia. Journal of Oncology Pharmacy Practice, 16, 179-188.
http://dx.doi.org/10.1177/1078155209351329
|
|
[47]
|
Van Der Pol, M.A., Broxterman, H.J., Pater, J.M., Feller, N., van der Maas, M., Weijers, G.W., et al. (2003) Function of the ABC Transporters, P-Glycoprotein, Multidrug Resistance Protein and Breast Cancer Resistance Protein, in Minimal Residual Disease in Acute Myeloid Leukemia. Haematologica, 88, 134-147.
|
|
[48]
|
Laska, D.A., Houchins, J.O., Pratt, S.E., Horn, J., Xia, X.L., Hanssen, B.R., et al. (2002) Characterization and Application of a Vinblastine-Selected CACO-2 Cell Line for Evaluation of P-Glycoprotein. In Vitro Cellular & Developmental Biology-Animal, 38, 401-410.
http://dx.doi.org/10.1290/1071-2690(2002)038<0401:CAAOAV>2.0.CO;2
|
|
[49]
|
Engman, H.A., Lennernas, H., Taipalensuu, J., Otter, C., Leidvik, B. and Artursson, P. (2001) CYP3A4, CYP3A5, and MDR1 in Human Small and Large Intestinal Cell Lines Suitable for Drug Transport Studies. Journal of Pharmaceutical Sciences, 90, 1736-1751.
http://dx.doi.org/10.1002/jps.1123
|
|
[50]
|
Lampen, A., Ebert, B., Stumkat, L., Jacob, J. and Seidel, A. (2004) Induction of Gene Expression of Xenobiotic Metabolism Enzymes and ABC-Transport Proteins by PAH and a Reconstituted PAH Mixture in Human Caco-2 Cells. Biochimica et Biophysica Acta, 1681, 38-46.
http://dx.doi.org/10.1016/j.bbaexp.2004.09.010
|
|
[51]
|
Muller, J., Sidler, D., Nachbur, U., Wastling, J., Brunner, T. and Hemphill, A. (2008) Thiazolides Inhibit Growth and Induce Glutathione-S-Transferase Pi (GSTP1)-Dependent Cell Death in Human Colon Cancer Cells. International Journal of Cancer, 123, 1797-1806.
http://dx.doi.org/10.1002/ijc.23755
|
|
[52]
|
Dai, J.Y., Yang, J.L. and Li, C. (2008) Transport and Metabolism of Flavonoids from Chinese Herbal Remedy Xiaochaihu-Tang across Human Intestinal Caco-2 Cell Monolayers. Acta Pharmacologica Sinica, 29, 1086-1093.
http://dx.doi.org/10.1111/j.1745-7254.2008.00850.x
|
|
[53]
|
Heikkinen, A.T., Monkkonen, J. and Korjamo, T. (2009) Kinetics of Cellular Retention during Caco-2 Permeation Experiments: Role of Lysosomal Sequestration and Impact on Permeability Estimates. Journal of Pharmacology and Experimental Therapeutics, 328, 882-892.
http://dx.doi.org/10.1124/jpet.108.145797
|
|
[54]
|
Ecker, G., Huber, M., Schmid, D. and Chiba, P. (1999) The Importance of a Nitrogen Atom in Modulators of Multidrug Resistance. Molecular Pharmacology, 56, 791-796.
|
|
[55]
|
Litman, T., Skovsgaard, T. and Stein, W.D. (2003) Pumping of Drugs by P-Glycoprotein: A Two-Step Process? Journal of Pharmacology and Experimental Therapeutics, 307, 846-853.
http://dx.doi.org/10.1124/jpet.103.056960
|
|
[56]
|
Kim, R.B., Wandel, C., Leake, B., Cvetkovic, M., Fromm, M.F., Dempsey, P.J., et al. (1999) Interrelationship between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein. Pharmaceutical Research, 16, 408-414.
http://dx.doi.org/10.1023/A:1018877803319
|
|
[57]
|
Marzolini, C., Paus, E., Buclin, T. and Kim, R.B. (2004) Polymorphisms in Human MDR1 (P-Glycoprotein): Recent Advances and Clinical Relevance. Clinical Pharmacology & Therapeutics, 75, 13-33.
http://dx.doi.org/10.1016/j.clpt.2003.09.012
|
|
[58]
|
Milne, R.J. and Buckley, M.M.T. (1991) Celiprolol—An Updated Review of Its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy in Cardiovascular Disease. Drugs, 41, 941-969.
http://dx.doi.org/10.2165/00003495-199141060-00009
|
|
[59]
|
Szakacs, G., Paterson, J.K., Ludwig, J.A., Booth-Genthe, C. and Gottesman, M.M. (2006) Targeting Multidrug Resistance in Cancer. Nature Reviews Drug Discovery, 5, 219-234.
http://dx.doi.org/10.1038/nrd1984
|
|
[60]
|
Krishna, R. and Mayer, L.D. (2001) Modulation of P-Glycoprotein (PGP) Mediated Multidrug Resistance (MDR) Using Chemosensitizers: Recent Advances in the Design of Selective MDR Modulators. Current Medicinal Chemistry-Anti-Cancer Agents, 1, 163-174.
http://dx.doi.org/10.2174/1568011013354705
|
|
[61]
|
Krishna, R. and Mayer, L.D. (2000) Multidrug Resistance (MDR) in Cancer: Mechanisms, Reversal Using Modulators of MDR and the Role of MDR Modulators in Influencing the Pharmacokinetics of Anticancer Drugs. European Journal of Pharmaceutical Sciences, 11, 265-283.
http://dx.doi.org/10.1016/S0928-0987(00)00114-7
|
|
[62]
|
Borowski, E., Bontemps-Gracz, M.M. and Piwkowska, A. (2005) Strategies for Overcoming ABC-Transporters-Mediated Multidrug Resistance (MDR) of Tumor Cells. Acta Biochimica Polonica, 52, 609-627.
|
|
[63]
|
Liscovitch, M. and Lavie, Y. (2002) Cancer Multidrug Resistance: A Review of Recent Drug Discovery Research. Idrugs, 5, 349-355.
|
|
[64]
|
El-Readi, M.Z., Hamdan, D., Farrag, N., El-Shazly, A. and Wink, M. (2010) Inhibition of P-Glycoprotein Activity by Limonin and Other Secondary Metabolites from Citrus Species in Human Colon and Leukaemia Cell Lines. European Journal of Pharmacology, 626, 139-145.
http://dx.doi.org/10.1016/j.ejphar.2009.09.040
|
|
[65]
|
Theis, J.G.W., Chan, H.S.L., Greenberg, M.L., Malkin, D., Karaskov, V., Moncica, I., et al. (2000) Assessment of Systemic Toxicity in Children Receiving Chemotherapy with Cyclosporine for Sarcoma. Medical and Pediatric Oncology, 34, 242-249.
http://dx.doi.org/10.1002/(SICI)1096-911X(200004)34:4<242::AID-MPO2>3.0.CO;2-U
|
|
[66]
|
Wang, R.B., Kuo, C.L., Lien, L.L. and Lien, E.J. (2003) Structure-Activity Relationship: Analyses of P-Glycoprotein Substrates and Inhibitors. Journal of Clinical Pharmacy and Therapeutics, 28, 203-228.
http://dx.doi.org/10.1046/j.1365-2710.2003.00487.x
|
|
[67]
|
Garrigos, M., Mir, L.M. and Orlowski, S. (1997) Competitive and Non-Competitive Inhibition of the Multidrug-Resistance-Associated P-Glycoprotein ATPase. Further Experimental Evidence for a Multisite Model. European Journal of Biochemistry, 244, 664-673.
http://dx.doi.org/10.1111/j.1432-1033.1997.00664.x
|
|
[68]
|
Dey, S., Ramachandra, M., Pastan, I., Gottesman, M.M. and Ambudkar, S.V. (1997) Evidence for Two Nonidentical Drug-Interaction Sites in the Human P-Glycoprotein. Proceedings of the National Academy of Sciences of the United States of America, 94, 10594-10599.
http://dx.doi.org/10.1073/pnas.94.20.10594
|
|
[69]
|
Ford, J.M. (1996) Experimental Reversal of P-Glycoprotein-Mediated Multidrug Resistance by Pharmacological Chemosensitisers. European Journal of Cancer, 32, 991-1001.
http://dx.doi.org/10.1016/0959-8049(96)00047-0
|
|
[70]
|
Tamai, I. and Safa, A.R. (1991) Azidopine Noncompetitively Interacts with Vinblastine and Cyclosporin a Binding to P-Glycoprotein in Multidrug Resistant Cells. Journal of Biological Chemistry, 266, 16796-16800.
|
|
[71]
|
Loo, T.W. and Clarke, D.M. (1995) Covalent Modification of Human P-Glycoprotein Mutants Containing a Single Cysteine in Either Nucleotide-Binding Fold Abolishes Drug-Stimulated ATPase Activity. Journal of Biological Chemistry, 270, 22957-22961.
http://dx.doi.org/10.1074/jbc.270.39.22957
|
|
[72]
|
Solary, E., Bidan, J.M., Calvo, F., Chauffert, B., Caillot, D., Mugneret, F., et al. (1991) P-Glycoprotein Expression and in Vitro Reversion of Doxorubicin Resistance by Verapamil in Clinical Specimens from Acute Leukaemia and Myeloma. Leukemia, 5, 592-597.
|
|
[73]
|
Muller, C., Goubin, F., Ferrandis, E., Cornil-Scharwtz, I., Bailly, J.D., Bordier, C., et al. (1995) Evidence for Transcriptional Control of Human Mdr1 Gene Expression by Verapamil in Multidrug-Resistant Leukemic Cells. Molecular Pharmacology, 47, 51-56.
|
|
[74]
|
Ozben, T. (2006) Mechanisms and Strategies to Overcome Multiple Drug Resistance in Cancer. FEBS Letters, 580, 2903-2909.
http://dx.doi.org/10.1016/j.febslet.2006.02.020
|
|
[75]
|
Guengerich, F.P. (1991) Reactions and Significance of Cytochrome P-450 Enzymes. Journal of Biological Chemistry, 266, 10019-10022.
|
|
[76]
|
Zhou, S.F., Gao, Y.H., Jiang, W.Q., Huang, M., Xu, A.L. and Paxton, J.W. (2003) Interactions of Herbs with Cytochrome P450. Drug Metabolism Reviews, 35, 35-98.
http://dx.doi.org/10.1081/DMR-120018248
|
|
[77]
|
Bertilsson, G., Heidrich, J., Svensson, K., Åsman, M., Jendeberg, L., Sydow-Bäckman, M., et al. (1998) Identification of a Human Nuclear Receptor Defines a New Signaling Pathway for CYP3A Induction. Proceedings of the National Academy of Sciences of the United States of America, 95, 12208-12213.
http://dx.doi.org/10.1073/pnas.95.21.12208
|
|
[78]
|
Urquhart, B.L., Tirona, R.G. and Kim, R.B. (2007) Nuclear Receptors and the Regulation of Drug-Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs. Journal of Clinical Pharmacology, 47, 566-578.
http://dx.doi.org/10.1177/0091270007299930
|
|
[79]
|
Tolson, A.H. and Wang, H. (2010) Regulation of Drug-Metabolizing Enzymes by Xenobiotic Receptors: PXR and CAR. Advanced Drug Delivery Reviews, 62, 1238-1249.
http://dx.doi.org/10.1016/j.addr.2010.08.006
|
|
[80]
|
Kimura, Y., Matsuo, M., Takahashi, K., Saeki, T., Kioka, N., Amachi, T. and Ueda, K. (2004) ATP Hydrolysis-Dependent Multidrug Efflux Transporter: MDR1/P-Glycoprotein. Current Drug Metabolism, 5, 1-10.
http://dx.doi.org/10.2174/1389200043489090
|
|
[81]
|
Lewis, A.D., Forrester, L.M., Hayes, J.D., Wareing, C.J., Carmichael, J., Harris, A.L., et al. (1989) Glutathione S-Transferase Isoenzymes in Human Tumours and Tumour Derived Cell Lines. British Journal of Cancer, 60, 327-331.
http://dx.doi.org/10.1038/bjc.1989.280
|
|
[82]
|
Green, J.A., Robertson, L.J. and Clark, A.H. (1993) Glutathione S-Transferase Expression in Benign and Malignant Ovarian Tumours. British Journal of Cancer, 68, 235-239.
http://dx.doi.org/10.1038/bjc.1993.321
|
|
[83]
|
Mannervik, B. and Jensson, H. (1982) Binary Combinations of Four Protein Subunits with Different Catalytic Specificities Explain the Relationship between Six Basic Glutathione S-Transferases in Rat Liver Cytosol. Journal of Biological Chemistry, 257, 9909-9912.
|
|
[84]
|
Morgenstern, R., Depierre, J.W. and Jornvall, H. (1985) Microsomal Glutathione Transferase. Primary Structure. Journal of Biological Chemistry, 260, 13976-13983.
|
|
[85]
|
Kuzmich, S. and Tew, K.D. (1991) Detoxification Mechanisms and Tumor Cell Resistance to Anticancer Drugs. Medicinal Research Reviews, 11, 185-217.
|
|
[86]
|
Ramsdell, H.S. and Eaton, D.L. (1990) Mouse Liver Glutathione S-Transferase Isoenzyme Activity toward Aflatoxin B1-8,9-Epoxide and Benzo[A]Pyrene-7,8-Dihydrodiol-9,10-Epoxide. Toxicology and Applied Pharmacology, 105, 216-225.
http://dx.doi.org/10.1016/0041-008X(90)90183-U
|
|
[87]
|
Falkner, K.C., Rushmore, T.H., Linder, M.W. and Prough, R.A. (1998) Negative Regulation of the Rat Glutathione S-Transferase A2 Gene by Glucocorticoids Involves a Canonical Glucocorticoid Consensus Sequence. Molecular Pharmacology, 53, 1016-1026.
|
|
[88]
|
Kasibhatla, S. and Tseng, B. (2003) Why Target Apoptosis in Cancer Treatment? Molecular Cancer Therapeutics, 2, 573-580.
|
|
[89]
|
Schultehermann, R., Bursch, W., Graslkraupp, B., Török, L., Ellinger, A. and Müllauer, I. (1995) Role of Active Cell Death (Apoptosis) in Multi-Stage Carcinogenesis. Toxicology Letters, 82-83, 143-148.
http://dx.doi.org/10.1016/0378-4274(95)03550-8
|
|
[90]
|
Collins, J.A., Schandl, C.A., Young, K.K., Vesely, J. and Willingham, M.C. (1997) Major DNA Fragmentation Is a Late Event in Apoptosis. Journal of Histochemistry & Cytochemistry, 45, 923-934.
http://dx.doi.org/10.1177/002215549704500702
|
|
[91]
|
Bruckheimer, E.M. and Kyprianou, N. (2000) Apoptosis in Prostate Carcinogenesis—A Growth Regulator and a Therapeutic Target. Cell and Tissue Research, 301, 153-162.
http://dx.doi.org/10.1007/s004410000196
|
|
[92]
|
Dive, C. and Hickman, J.A. (1991) Drug-Target Interactions: Only the First Step in the Commitment to a Programmed Cell Death? British Journal of Cancer, 64, 192-196.
http://dx.doi.org/10.1038/bjc.1991.269
|
|
[93]
|
Launay, S., Hermine, O., Fontenay, M., Kroemer, G., Solary, E. and Garrido, C. (2005) Vital Functions for Lethal Caspases. Oncogene, 24, 5137-5148.
http://dx.doi.org/10.1038/sj.onc.1208524
|
|
[94]
|
Thornberry, N.A. and Lazebnik, Y. (1998) Caspases: Enemies Within. Science, 281, 1312-1316.
http://dx.doi.org/10.1126/science.281.5381.1312
|
|
[95]
|
Hajra, K.M. and Liu, J.R. (2004) Apoptosome Dysfunction in Human Cancer. Apoptosis, 9, 691-704.
http://dx.doi.org/10.1023/B:APPT.0000045786.98031.1d
|
|
[96]
|
Gottlieb, R.A., Nordberg, J., Skowronski, E. and Babior, B.M. (1996) Apoptosis Induced in Jurkat Cells by Several Agents Is Preceded by Intracellular Acidification. Proceedings of the National Academy of Sciences of the United States of America, 93, 654-658.
http://dx.doi.org/10.1073/pnas.93.2.654
|
|
[97]
|
Robinson, L.J., Roberts, W.K., Ling, T.T., Lamming, D., Sternberg, S.S. and Roepe, P.D. (1997) Human MDR 1 Protein Overexpression Delays the Apoptotic Cascade in Chinese Hamster Ovary Fibroblasts. Biochemistry, 36, 11169-11178.
http://dx.doi.org/10.1021/bi9627830
|
|
[98]
|
Kinghorn, A.D., Balandrin, M.F., American Chemical Society, Division of Agricultural and Food Chemistry, et al. (1993) Human Medicinal Agents from Plants. American Chemical Society, Washington DC, xii, 356 p.
|
|
[99]
|
Cordell, G.A. (2002) Natural Products in Drug Discovery—Creating a New Vision. Phytochemistry Reviews, 1, 261-273.
http://dx.doi.org/10.1023/A:1026094701495
|
|
[100]
|
Nobili, S., Lippi, D., Witort, E., Donnini, M., Bausi, L., Mini, E. and Capaccioli, S. (2009) Natural Compounds for Cancer Treatment and Prevention. Pharmacological Research, 59, 365-378.
http://dx.doi.org/10.1016/j.phrs.2009.01.017
|
|
[101]
|
Colegate, S.M. and Molyneux, R.J. (2008) Bioactive Natural Products: Detection, Isolation, and Structural Determination. 2nd Edition, CRC Press, Boca Raton, xiii, 605 p.
|
|
[102]
|
Newman, D.J. and Cragg, G.M. (2007) Natural Products as Sources of New Drugs over the Last 25 Years. Journal of Natural Products, 70, 461-477.
http://dx.doi.org/10.1021/np068054v
|
|
[103]
|
Richardson, M.A., Sanders, T., Palmer, J.L., Greisinger, A. and Singletary, S.E. (2000) Complementary/Alternative Medicine Use in a Comprehensive Cancer Center and the Implications for Oncology. Journal of Clinical Oncology, 18, 2505-2514.
|
|
[104]
|
Sparber, A., Jonas, W., White, J., Derenzo, E., Johnson, E. and Bergerson, S. (2000) Cancer Clinical Trials and Subject Use of Natural Herbal Products. Cancer Investigation, 18, 436-439.
http://dx.doi.org/10.3109/07357900009032815
|
|
[105]
|
Boik, J. (2001) Natural Compounds in Cancer Therapy. Oregon Medical Press, Princeton, xiii, 521 p.
|
|
[106]
|
El-Readi, M.Z., Eid, S., Ashour, M.L., Tahrani, A. and Wink, M. (2013) Modulation of Multidrug Resistance in Cancer Cells by Chelidonine and Chelidonium majus Alkaloids. Phytomedicine, 20, 282-294.
http://dx.doi.org/10.1016/j.phymed.2012.11.005
|
|
[107]
|
Eid, S.Y., El-Readi, M.Z., Eldin, E.E., Fatani, S.H. and Wink, M. (2013) Influence of Combinations of Digitonin with Selected Phenolics, Terpenoids, and Alkaloids on the Expression and Activity of P-Glycoprotein in Leukaemia and Colon Cancer Cells. Phytomedicine, 21, 47-61.
http://dx.doi.org/10.1016/j.phymed.2013.07.019
|
|
[108]
|
Eid, S.Y., El-Readi, M.Z. and Wink, M. (2012) Carotenoids Reverse Multidrug Resistance in Cancer Cells by Interfering with ABC-Transporters. Phytomedicine, 19, 977-987.
http://dx.doi.org/10.1016/j.phymed.2012.05.010
|
|
[109]
|
Eid, S.Y., El-Readi, M.Z. and Wink, M. (2012) Digitonin Synergistically Enhances the Cytotoxicity of Plant Secondary Metabolites in Cancer Cells. Phytomedicine, 19, 1307-1314.
http://dx.doi.org/10.1016/j.phymed.2012.09.002
|
|
[110]
|
Eid, S.Y., El-Readi, M.Z. and Wink, M. (2012) Synergism of Three-Drug Combinations of Sanguinarine and Other Plant Secondary Metabolites with Digitonin and Doxorubicin in Multi-Drug Resistant Cancer Cells. Phytomedicine, 19, 1288-1297.
http://dx.doi.org/10.1016/j.phymed.2012.08.010
|
|
[111]
|
Wink, M., Ashour, M.L. and El-Readi, M.Z. (2012) Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents. Frontiers in Microbiology, 3, 130.
http://dx.doi.org/10.3389/fmicb.2012.00130
|
|
[112]
|
Wink, M. (1999) Introduction: Biochemistry, Role and Biotechnology of Secondary Metabolites. Annual Plant Reviews, 2, 1-16.
|
|
[113]
|
Wink, M. (2003) Evolution of Secondary Metabolites from an Ecological and Molecular Phylogenetic Perspective. Phytochemistry, 64, 3-19.
http://dx.doi.org/10.1016/S0031-9422(03)00300-5
|
|
[114]
|
Wink, M. (2008) Plant Secondary Metabolism: Diversity, Function and Its Evolution. Natural Product Communications, 3, 1205-1216.
|
|
[115]
|
Wink M (1999) Introduction: Biochemistry, Role and Biotechnology of Secondary Metabolites. In: Wink, M., Ed., Functions of Plant Secondary Metabolites and Their Exploitation in Biotechnology, Academic, Sheffield, 1-16.
|
|
[116]
|
Mann, J. (1994) Natural Products: Their Chemistry and Biological Significance. 1st Edition, Longman Scientific & Technical, Wiley, Harlow, Essex, England, New York, ix, 455 p.
|
|
[117]
|
Harborne, J.B. and Williams, C.A. (2000) Advances in Flavonoid Research Since 1992. Phytochemistry, 55, 481-504.
http://dx.doi.org/10.1016/S0031-9422(00)00235-1
|
|
[118]
|
Manach, C., Morand, C., Gil-Izquierdo, A., Bouteloup-Demange, C. and Rémésy, C. (2003) Bioavailability in Humans of the Flavanones Hesperidin and Narirutin after the Ingestion of Two Doses of Orange Juice. European Journal of Clinical Nutrition, 57, 235-242.
http://dx.doi.org/10.1038/sj.ejcn.1601547
|
|
[119]
|
Vallejo, F., Larrosa, M., Escudero, E., Zafrilla, M.P., Cerda?, B., Boza, J., et al. (2010) Concentration and Solubility of Flavanones in Orange Beverages Affect Their Bioavailability in Humans. Journal of Agricultural and Food Chemistry, 58, 6516-6524.
http://dx.doi.org/10.1021/jf100752j
|
|
[120]
|
Crozier, A., Clifford, M.N. and Ashihara, H. (2006) Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet. Blackwell Pub., Oxford, Ames, Iowa, xii, 372 p.
|
|
[121]
|
Cho, Y.A., Kim, J., Park, K.S., Lim, S.Y., Shin, A., Sung, M.K. and Ro, J. (2010) Effect of Dietary Soy Intake on Breast Cancer Risk According to Menopause and Hormone Receptor Status. European Journal of Clinical Nutrition, 64, 924-932.
http://dx.doi.org/10.1038/ejcn.2010.95
|
|
[122]
|
Middleton, E., Kandaswami, C. and Theoharides, T.C. (2000) The Effects of Plant Flavonoids on Mammalian Cells: Implications for Inflammation, Heart Disease, and Cancer. Pharmacological Reviews, 52, 673-751.
|
|
[123]
|
Cao, J., Chen, X., Liang, J., Yu, X.Q., Xu, A.L., Chan, E., et al. (2007) Role of P-Glycoprotein in the Intestinal Absorption of Glabridin, an Active Flavonoid from the Root of Glycyrrhiza glabra. Drug Metabolism and Disposition, 35, 539-553.
http://dx.doi.org/10.1124/dmd.106.010801
|
|
[124]
|
Wang, Y., Cao, J. and Zeng, S. (2005) Involvement of P-Glycoprotein in Regulating Cellular Levels of Ginkgo Flavonols: Quercetin, Kaempferol, and Isorhamnetin. Journal of Pharmacy and Pharmacology, 57, 751-758.
http://dx.doi.org/10.1211/0022357056299
|
|
[125]
|
Cermak, R. and Wolffram, S. (2006) The Potential of Flavonoids to Influence Drug Metabolism and Pharmacokinetics by Local Gastrointestinal Mechanisms. Current Drug Metabolism, 7, 729-744.
http://dx.doi.org/10.2174/138920006778520570
|
|
[126]
|
Conseil, G., Baubichon-Cortay, H., Dayan, G., Jault, J.M., Barron, D. and Di Pietro, A. (1998) Flavonoids: A Class of Modulators with Bifunctional Interactions at Vicinal ATP- and Steroid-Binding Sites on Mouse P-Glycoprotein. Proceedings of the National Academy of Sciences of the United States of America, 95, 9831-9836.
http://dx.doi.org/10.1073/pnas.95.17.9831
|
|
[127]
|
Johnson, W.W., Wang, E.J., Barecki-Roach, M., et al. (2002) Allosteric Elevation of P-Glycoprotein Function by a Catechin in Green Tea. Drug Metabolism Reviews, 34, 87.
|
|
[128]
|
Morris, M.E. and Zhang, S. (2006) Flavonoid-Drug Interactions: Effects of Flavonoids on ABC Transporters. Life Sciences, 78, 2116-2130.
http://dx.doi.org/10.1016/j.lfs.2005.12.003
|
|
[129]
|
Shapiro, A.B. and Ling, V. (1997) Positively Cooperative Sites for Drug Transport by P-Glycoprotein with Distinct Drug Specificities. European Journal of Biochemistry, 250, 130-137.
http://dx.doi.org/10.1111/j.1432-1033.1997.00130.x
|
|
[130]
|
Di Pietro, A., Conseil, G., Perez-Victoria, J.M., Dayan, G., Baubichon-Cortay, H., Trompier, D., et al. (2002) Modulation by Flavonoids of Cell Multidrug Resistance Mediated by P-Glycoprotein and Related ABC Transporters. Cellular and Molecular Life Sciences CMLS, 59, 307-322.
http://dx.doi.org/10.1007/s00018-002-8424-8
|
|
[131]
|
Tang, M., Ogawa, K., Asamoto, M., Hokaiwado, N., Seeni, A., Suzuki, S., et al. (2007) Protective Effects of Citrus Nobiletin and Auraptene in Transgenic Rats Developing Adenocarcinoma of the Prostate (TRAP) and Human Prostate Carcinoma Cells. Cancer Science, 98, 471-477.
http://dx.doi.org/10.1111/j.1349-7006.2007.00417.x
|
|
[132]
|
Ju-Ichi, M. (2005) Chemical Study of Citrus Plants in the Search for Cancer Chemopreventive Agents. Yakugaku Zasshi, 125, 231-254.
http://dx.doi.org/10.1248/yakushi.125.231
|
|
[133]
|
Takanaga, H., Ohnishi, A., Yamada, S., Matsuo, H., Morimoto, S., Shoyama, Y., et al. (2000) Polymethoxylated Flavones in Orange Juice Are Inhibitors of P-Glycoprotein but Not Cytochrome P450 3A4. Journal of Pharmacology and Experimental Therapeutics, 293, 230-236.
|
|
[134]
|
Dresser, G.K. and Bailey, D.G. (2003) The Effects of Fruit Juices on Drug Disposition: A New Model for Drug Interactions. European Journal of Clinical Investigation, 33, 10-16.
http://dx.doi.org/10.1046/j.1365-2362.33.s2.2.x
|
|
[135]
|
Evans, A.M. (2000) Influence of Dietary Components on the Gastrointestinal Metabolism and Transport of Drugs. Therapeutic Drug Monitoring, 22, 131-136.
http://dx.doi.org/10.1097/00007691-200002000-00028
|
|
[136]
|
Ioannides, C. (2002) Topics in Xenobiochemistry. Pharmacokinetic Interactions between Herbal Remedies and Medicinal Drugs. Xenobiotica, 32, 451-478.
http://dx.doi.org/10.1080/00498250210124147
|
|
[137]
|
Dahan, A. and Altman, H. (2004) Food-Drug Interaction: Grapefruit Juice Augments Drug Bioavailability—Mechanism, Extent and Relevance. European Journal of Clinical Nutrition, 58, 1-9.
http://dx.doi.org/10.1038/sj.ejcn.1601736
|
|
[138]
|
Chen, A.C. and Donovan, S.M. (2004) Genistein at a Concentration Present in Soy Infant Formula Inhibits Caco-2BBe Cell Proliferation by Causing G2/M Cell Cycle Arrest. Journal of Nutrition, 134, 1303-1308.
|
|
[139]
|
Horie, N., Hirabayashi, N., Takahashi, Y., Miyauchi, Y., Taguchi, H. and Takeishi, K. (2005) Synergistic Effect of Green Tea Catechins on Cell Growth and Apoptosis Induction in Gastric Carcinoma Cells. Biological and Pharmaceutical Bulletin, 28, 574-579.
http://dx.doi.org/10.1248/bpb.28.574
|
|
[140]
|
Kaneuchi, M., Sasaki, M., Tanaka, Y., Sakuragi, N., Fujimoto, S. and Dahiya, R. (2003) Quercetin Regulates Growth of Ishikawa Cells through the Suppression of EGF and Cyclin D1. International Journal of Oncology, 22, 159-164.
|
|
[141]
|
Kumi-Diaka, J., Sanderson, N.A. and Hall, A. (2000) The Mediating Role of Caspase-3 Protease in the Intracellular Mechanism of Genistein-Induced Apoptosis in Human Prostatic Carcinoma Cell Lines, DU145 and LNCaP. Biology of the Cell, 92, 595-604.
http://dx.doi.org/10.1016/S0248-4900(00)01109-6
|
|
[142]
|
Nguyen, T.T., Tran, E., Nguyen, T.H., Do, P.T., Huynh, T.H. and Huynh, H. (2004) The Role of Activated MEK-ERK Pathway in Quercetin-Induced Growth Inhibition and Apoptosis in A549 Lung Cancer Cells. Carcinogenesis, 25, 647-659.
http://dx.doi.org/10.1093/carcin/bgh052
|
|
[143]
|
Banthorpe, D. (1991) Classification of Terpenoids and General Procedures for Their Characterization. In: Charlwood, B. and Banthorpe, D., Eds., Methods in Plant Biochemistry: Terpenoids, Academic Press, London, 1-41.
|
|
[144]
|
Davis, E. and Croteau, R. (2000) Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and Diterpenes. In: Leeper, F. and Vederas, J., Eds., Topics in Current Chemistry: Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids, Springer, Berlin, New York, 53-95.
|
|
[145]
|
Gershenzon, J. and Kreis, W. (1999) Biochemistry of Terpenoids. In: Wink, M., Ed., Biochemistry of Plant Secondary Metabolism, Annual Plant Reviews, Sheffield Academic Press, CRC Press, Sheffield, Boca Raton, 222-299.
|
|
[146]
|
Roy, A. and Saraf, S. (2006) Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom. Biological & Pharmaceutical Bulletin, 29, 191-201.
http://dx.doi.org/10.1248/bpb.29.191
|
|
[147]
|
Manners, G.D., Jacob, R.A., Breksa III, A.P., Schoch, T.K. and Hasegawa, S. (2003) Bioavailability of Citrus Limonoids in Humans. Journal of Agricultural and Food Chemistry, 51, 4156-4161.
http://dx.doi.org/10.1021/jf0300691
|
|
[148]
|
Berhow, M.A., Hasegawa, S., Manners, G.D., et al. (2000) Citrus Limonoids: Functional Chemicals in Agriculture and Food. American Chemical Society, Washington DC, xiii, 253 p.
|
|
[149]
|
Poulose, S.M., Harris, E.D. and Patil, B.S. (2005) Citrus Limonoids Induce Apoptosis in Human Neuroblastoma Cells and Have Radical Scavenging Activity. Journal of Nutrition, 135, 870-877.
|
|
[150]
|
Miyagi, Y., Om, A.S., Chee, K.M. and Bennink, M.R. (2000) Inhibition of Azoxymethane-Induced Colon Cancer by Orange Juice. Nutrition and Cancer—An International Journal, 36, 224-229.
http://dx.doi.org/10.1207/S15327914NC3602_12
|
|
[151]
|
Berhow, M.A., Omura, M., Ohta, H., Ozaki, Y. and Hasegawa, S. (1994) Limonoids in Seeds of 3 Citrus Hybrids Related to Citrus ichangensis. Phytochemistry, 36, 923-925.
http://dx.doi.org/10.1016/S0031-9422(00)90464-3
|
|
[152]
|
Silalahi, J. (2002) Anticancer and Health Protective Properties of Citrus Fruit Components. Asia Pacific Journal of Clinical Nutrition, 11, 79-84.
http://dx.doi.org/10.1046/j.1440-6047.2002.00271.x
|
|
[153]
|
Tanaka, T., Kohno, H., Tsukio, Y., Honjo, S., Tanino, M., Miyake, M. and Wada, K. (2000) Citrus Limonoids Obacunone and Limonin Inhibit Azoxymethane-Induced Colon Carcinogenesis in Rats. BioFactors, 13, 213-218.
http://dx.doi.org/10.1002/biof.5520130133
|
|
[154]
|
Madyastha, K.M. and Venkatakrishnan, K. (2000) Structural Flexibility in the Biocatalyst-Mediated Functionalization of Ring “A” in Salannin, a Tetranortriterpene from Azadirachta indica. Journal of the Chemical Society, Perkin Transactions, 1, 3055-3062.
http://dx.doi.org/10.1039/b004260i
|
|
[155]
|
Dewick, P.M. (2009) Medicinal Natural Products: A Biosynthetic Approach. 3rd Edition, Wiley, Chichester, x, 539 p.
|
|
[156]
|
Katan, M.B., Grundy, S.M., Jones, P., Law, M., Miettinen, T. and Paoletti, R. (2003) Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels. Mayo Clinic Proceedings, 78, 965-978.
http://dx.doi.org/10.1016/S0025-6196(11)63144-3
|
|
[157]
|
Lichtenstein, A.H. and Deckelbaum, R.J. (2001) AHA Science Advisory. Stanol/Sterol Ester-Containing Foods and Blood Cholesterol Levels. A Statement for Healthcare Professionals from the Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association. Circulation, 103, 1177-1179.
http://dx.doi.org/10.1161/01.CIR.103.8.1177
|
|
[158]
|
Awad, A.B. and Fink, C.S. (2002) Phytosterols as Anticancer Dietary Components: Evidence and Mechanism of Action (Reprinted from Vol 130, Pg 2127, 2000). Journal of Nutrition, 132, 2127-2130.
|
|
[159]
|
Oram, J.F. and Vaughan, A.M. (2006) ATP-Binding Cassette Cholesterol Transporters and Cardiovascular Disease. Circulation Research, 99, 1031-1043.
http://dx.doi.org/10.1161/01.RES.0000250171.54048.5c
|
|
[160]
|
Sarkadi, B., Homolya, L., Szakacs, G. and Váradi, A. (2006) Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System. Physiological Reviews, 86, 1179-1236.
http://dx.doi.org/10.1152/physrev.00037.2005
|
|
[161]
|
Wink, M. (2008) Evolutionary Advantage and Molecular Modes of Action of Multi-Component Mixtures Used in Phytomedicine. Current Drug Metabolism, 9, 996-1009.
http://dx.doi.org/10.2174/138920008786927794
|
|
[162]
|
Brobst, D.E., Ding, X., Creech, K.L., Goodwin, B., Kelley, B. and Staudinger, J.L. (2004) Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor. Journal of Pharmacology and Experimental Therapeutics, 310, 528-535.
http://dx.doi.org/10.1124/jpet.103.064329
|
|
[163]
|
Roberts, M.F. and Wink, M. (1998) Alkaloids: Biochemistry, Ecology, and Medicinal Applications. Springer, New York, 1-7.
|
|
[164]
|
Wink, M. (1998) A Short History of Alkaloids. In: Alkaloids: Biochemistry, Ecology, and Medicinal Applications, Springer, New York, 11-43.
|
|
[165]
|
Wink, M. (2007) Molecular Modes of Action of Cytotoxic Alkaloids: From DNA Intercalation, Spindle Poisoning, Topoisomerase Inhibition to Apoptosis and Multiple Drug Resistance. Alkaloids: Chemistry and Biology, 64, 1-47.
http://dx.doi.org/10.1016/S1099-4831(07)64001-2
|
|
[166]
|
Zdarilova, A., Malikova, J., Dvorak, Z., Ulrichová, J. and Simánek, V. (2006) Quaternary Isoquinoline Alkaloids Sanguinarine and Chelerythrine. In Vitro and in Vivo Effects. Chemické Listy, 100, 30-41.
|
|
[167]
|
Fu, L.W., Deng, Z.A., Pan, Q.C. and Fan, W. (2001) Screening and Discovery of Novel MDR Modifiers from Naturally Occurring Bisbenzylisoquinoline Alkaloids. Anticancer Research, 21, 2273-2280.
|
|
[168]
|
Jakubikova, J., Duraj, J., Hunakova, L., Chorvath, B. and Sedlak, J. (2002) PK11195, an Isoquinoline Carboxamide Ligand of the Mitochondrial Benzodiazepine Receptor, Increased Drug Uptake and Facilitated Drug-Induced Apoptosis in Human Multidrug-Resistant Leukemia Cells in Vitro. Neoplasma, 49, 231-236.
|
|
[169]
|
He, L. and Liu, G.Q. (2002) Effects of Various Principles from Chinese Herbal Medicine on Rhodamine123 Accumulation in Brain Capillary Endothelial Cells. Acta Pharmacologica Sinica, 23, 591-596.
|
|
[170]
|
Wakusawa, S., Nakamura, S., Tajima, K., Miyamoto, K., Hagiwara, M. and Hidaka, H. (1992) Overcoming of Vinblastine Resistance by Isoquinolinesulfonamide Compounds in Adriamycin-Resistant Leukemia Cells. Molecular Pharmacology, 41, 1034-1038.
|
|
[171]
|
Moller, M., Weiss, J. and Wink, M. (2006) Reduction of Cytotoxicity of the Alkaloid Emetine through P-Glycoprotein (MDR1/ABCB1) in Human Caco-2 Cells and Leukemia Cell Lines. Planta Medica, 72, 1121-1126.
http://dx.doi.org/10.1055/s-2006-941546
|
|
[172]
|
Belyaeva, T., Leontieva, E., Shpakov, A., Mozhenok, T. and Faddejeva, M. (2003) Sensitivity of Lysosomal Enzymes to the Plant Alkaloid Sanguinarine: Comparison with Other SH-Specific Agents. Cell Biology International, 27, 887-895.
http://dx.doi.org/10.1016/S1065-6995(03)00161-6
|
|
[173]
|
Salminen, K.A., Meyer, A., Jerabkova, L., Korhonen, L.E., Rahnasto, M., Juvonen, R.O., et al. (2010) Inhibition of Human Drug Metabolizing Cytochrome P450 Enzymes by Plant Isoquinoline Alkaloids. Phytomedicine, 18, 533-538.
|
|
[174]
|
Adhami, V.M., Aziz, M.H., Mukhtar, H. and Ahmad, N. (2003) Activation of Prodeath Bcl-2 Family Proteins and Mitochondrial Apoptosis Pathway by Sanguinarine in Immortalized Human HaCaT Keratinocytes. Clinical Cancer Research, 9, 3176-3182.
|
|
[175]
|
Adhami, V.M., Aziz, M.H., Reagan-Shaw, S.R., Nihal, M., Mukhtar, H. and Ahmad, N. (2004) Sanguinarine Causes Cell Cycle Blockade and Apoptosis of Human Prostate Carcinoma Cells via Modulation of Cyclin Kinase Inhibitor-Cyclin-Cyclin-Dependent Kinase Machinery. Molecular Cancer Therapeutics, 3, 933-940.
|
|
[176]
|
Malikova, J., Zdarilova, A. and Hlobilkova, A. (2006) Effects of Sanguinarine and Chelerythrine on the Cell Cycle and Apoptosis. Biomedical Papers of the Medical Faculty of Palacky University, 150, 5-12.
http://dx.doi.org/10.5507/bp.2006.001
|
|
[177]
|
Ding, Z.H., Tang, S.C., Weerasinghe, P., Yang, X., Pater, A. and Liepins, A. (2002) The Alkaloid Sanguinarine Is Effective against Multidrug Resistance in Human Cervical Cells via Bimodal Cell Death. Biochemical Pharmacology, 63, 1415-1421.
http://dx.doi.org/10.1016/S0006-2952(02)00902-4
|
|
[178]
|
Moller, M., Herzer, K., Wenger, T., Herr, I. and Wink, M. (2007) The Alkaloid Emetine as a Promising Agent for the Induction and Enhancement of Drug-Induced Apoptosis in Leukemia Cells. Oncology Reports, 18, 737-744.
|
|
[179]
|
Moller, M. and Wink, M. (2007) Characteristics of Apoptosis Induction by the Alkaloid Emetine in Human Tumour Cell Lines. Planta Medica, 73, 1389-1396.
http://dx.doi.org/10.1055/s-2007-990229
|
|
[180]
|
Rosenkranz, V. and Wink, M. (2008) Alkaloids Induce Programmed Cell Death in Bloodstream Forms of Trypanosomes (Trypanosoma b. brucei). Molecules, 13, 2462-2473.
http://dx.doi.org/10.3390/molecules13102462
|
|
[181]
|
Van Wyk, B.E. and Wink, M. (2004) Medicinal Plants of the World: An Illustrated Scientific Guide to Important Medicinal Plants and Their Uses. 1st Edition, Timber Press, Portland, 480 p.
|
|
[182]
|
Bartak, P., Simanek, V., Vlckova, M., Ulrichová, J. and Vespalec, R. (2003) Interactions of Sanguinarine and Chelerythrine with Molecules Containing a Mercapto Group. Journal of Physical Organic Chemistry, 16, 803-810.
http://dx.doi.org/10.1002/poc.659
|
|
[183]
|
Ulrichova, J., Dvorak, Z., Vicar, J., Lata, J., Smrzová, J., Sedo, A. and Simánek, V. (2001) Cytotoxicity of Natural Compounds in Hepatocyte Cell Culture Models: The Case of Quaternary Benzo[C]phenanthridine Alkaloids. Toxicology Letters, 125, 125-132.
http://dx.doi.org/10.1016/S0378-4274(01)00430-1
|
|
[184]
|
Slaninova, I., Taborska, E., Bochorakova, H. and Slanina, J. (2001) Interaction of Benzo[C]phenanthridine and Protoberberine Alkaloids with Animal and Yeast Cells. Cell Biology and Toxicology, 17, 51-63.
http://dx.doi.org/10.1023/A:1010907231602
|
|
[185]
|
Walterova, D., Ulrichova, J., Preininger, V., Simanek, V., Lenfeld, J. and Lasovsky, J. (1981) Inhibition of Liver Alanine Aminotransferase Activity by Some Benzophenanthridine Alkaloids. Journal of Medicinal Chemistry, 24, 1100-1103.
http://dx.doi.org/10.1021/jm00141a019
|
|
[186]
|
Stiborova, M., Simanek, V., Frei, E., Hobza, P. and Ulrichová, J. (2002) DNA Adduct Formation from Quaternary Benzo[C]phenanthridine Alkaloids Sanguinarine and Chelerythrine as Revealed by the P-32-Postlabeling Technique. Chemico-Biological Interactions, 140, 231-242.
http://dx.doi.org/10.1016/S0009-2797(02)00038-8
|
|
[187]
|
Das, M., Ansari, K.M., Dhawan, A., Shukla, Y. and Khanna, S.K. (2005) Correlation of DNA Damage in Epidemic Dropsy Patients to Carcinogenic Potential of Argemone Oil and Isolated Sanguinarine Alkaloid in Mice. International Journal of Cancer, 117, 709-717.
http://dx.doi.org/10.1002/ijc.21234
|
|
[188]
|
Wink, M. (2006) Chapter 11 Importance of Plant Secondary Metabolites for Protection against Insects and Microbial Infections. In: Mahendra, R. and María Cecilia, C., Eds., Advances in Phytomedicine, Vol. 3, Elsevier, Amsterdam, 251-268.
|