Development of the Japanese Medication Adherence Scale and Verification of Its Reliability and Validity in Hypertensive Patients

Rika Shimada¹, Yasuaki Dohi², Kazunori Kimura³, Satoshi Fujii⁴

¹Department of Critical Care Nursing, Graduate School of Nursing, Nagoya City University, Nagoya, Japan.
²Department of Cardio-Renal Medicine and Hypertension, Graduate School of Medicine, Nagoya City University, Nagoya, Japan.
³Pharmaceutical Department, Nagoya City University Hospital, Nagoya, Japan.
⁴Department of Laboratory Medicine, Asahikawa Medical University, Asahikawa, Japan.

DOI: 10.4236/pp.2015.63014                

Abstract

A 32-Item Japanese Medication Adherence Scale had been developed as a tool for evaluating the medication-taking behavior of hypertensive patients and predicting therapeutic efficacy, and an Internet survey of 990 hypertensive patients throughout Japan was performed. As a result, factor 1 “Expectation of pharmacological efficacy” (9 items), factor 2 “Motivation to be self-controlled in taking medication” (6 items), and factor 3 “Negative feelings about taking medication” (4 items) were identified, comprising a total of 19 items. The scale was highly reliable. Because it proved capable of discriminating between the 2 groups with different medication-taking status and blood pressure, its validity had also been confirmed.

Keywords

Drug Therapy, Hypertension, Measure, Medication Adherence Scale

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	The Japanese Society of Hypertension (2014) The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH2014). Tokyo.
[2]	World Health Organization (2013) WHO: A Global Brief On Hypertension: Silent Killer, Global Public Health Crisis. http://www.who.int/features/2013/japan_blood_pressure/en/index.html#
[3]	The Ministry of Health (2006) Labor and Welfare: The National Medical Expenditures in the Heisei 16 Fiscal Year. http://www.mhlw.go.jp/toukei/saikin/hw/k-iryohi/04/kekka6.html
[4]	Mendis, S. and Salas, M. (2013) Hypertension, in World Health Organization, Adherence to Long-Term Therapies: Evidence for Action, 107-114. Geneva. http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf
[5]	Cohen, S.M. (2009) Concept Analysis of Adherence in the Context of Cardiovascular Risk Reduction. Nursing Forum, 44, 25-36. http://dx.doi.org/10.1111/j.1744-6198.2009.00124.x
[6]	Bangalore, S., Kamalakkannan, G., Parkar, S. and Messerli, F.H. (2007) Fixed-Dose Combinations Improve Medication Compliance: A Meta-Analysis. American Journal of Medicine, 120, 713-719. http://dx.doi.org/10.1016/j.amjmed.2006.08.033
[7]	Schroeder, K., Fahey, T. and Ebrahim, S. (2004) How Can We Improve Adherence to Blood Pressure-Lowering Medication in Ambulatory Care? Systematic Review of Randomized Controlled Trials. Archives of Internal Medicine, 164, 722-732. http://dx.doi.org/10.1001/archinte.164.7.722
[8]	Collins, U.K. (1999) Collins Concise Dictionary. 4th Edition, HarperCollins Publishers, Glasgow, 16.
[9]	Rajpura, J. and Nayak, R. (2014) Medication Adherence in a Sample of Elderly Suffering from Hypertension: Evaluating the Influence of Illness Perceptions, Treatment Beliefs, and Illness Burden. Journal of Managed Care Pharmacy, 19, 58-65.
[10]	Abel, W.M. and Efird, J.T. (2013) The Association between Trust in Health Care Providers and Medication Adherence among Black Women with Hypertension. Front Public Health, 1, 66.
[11]	Harmon, G., Lefante, J. and Krousel-Wood, M. (2006) Overcoming Barriers: The Role of Providers in Improving Patient Adherence to Antihypertensive Medications. Current Opinion in Cardiology, 21, 310-315. http://dx.doi.org/10.1097/01.hco.0000231400.10104.e2
[12]	Gerbino, P.P. and Shoheiber, O. (2007) Adherence Patterns among Patients Treated with Fixed-Dose Combination versus Separate Antihypertensive Agents. American Journal of Health-System Pharmacy, 64, 1279-1283. http://dx.doi.org/10.2146/ajhp060434
[13]	Lee, J.K., Grace, K.A. and Taylor, A.J. (2006) Effect of a Pharmacy Care Program on Medication Adherence and Persistence, Blood Pressure, and Low-Density Lipoprotein Cholesterol: A Randomized Controlled Trial. The Journal of the American Medical Association, 296, 2563-2571. http://dx.doi.org/10.1001/jama.296.21.joc60162
[14]	Wee, L.E. and Koh, G.C. (2012) Individual and Neighborhood Social Factors of Hypertension Management in a Low-Socioeconomic Status Population: A Community-Based Case-Control Study in Singapore. Hypertension Research, 35, 295-303. http://dx.doi.org/10.1038/hr.2011.187
[15]	Working Group on the Summit on Combination Therapy for CVD (2014) Combination Pharmacotherapy to Prevent Cardiovascular Disease: Present Status and Challenges. European Heart Journal, 35, 353-364. http://dx.doi.org/10.1093/eurheartj/eht407
[16]	Morisky, D.E., Green, L.W. and Levine, D.M. (1986) Concurrent and Predictive Validity of a Self-Reported Measure of Medication Adherence. Medical Care, 24, 67-74. http://dx.doi.org/10.1097/00005650-198601000-00007
[17]	Morisky, D.E., Ang, A., Krousel-Wood, M. and Ward, H.J. (2008) Predictive Validity of a Medication Adherence Measure in an Outpatient Setting. Journal of Clinical Hypertension, 10, 348-354. http://dx.doi.org/10.1111/j.1751-7176.2008.07572.x