Dynamic Contrast-Enhanced MRI of Mouse Liver: A Feasibility Study Using a Dual-Input Two-Compartment Tracer Kinetic Model

Septian Hartono^1,2*, Choon Hua Thng², Kai Hsiang Chuang³, Huynh Hung⁴, Tong San Koh²

¹School of Electrical & Electronic Engineering, Nanyang Technological University, Singapore City, Singapore.
²Department of Oncologic Imaging, National Cancer Centre Singapore, Singapore City, Singapore.
³Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore City, Singapore.
⁴Laboratory of Molecular Endocrinology, National Cancer Centre Singapore, Singapore City, Singapore.

DOI: 10.4236/jbise.2015.82009                

Abstract

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been widely applied to evaluate microcirculatory parameters in clinical settings. However, pre-clinical studies involving DCE-MRI of small animals remain challenging with the requirement for high spatial and temporal resolution for quantitative tracer kinetic analysis. This study illustrates the feasibility of applying a high temporal resolution (2 s) protocol for liver imaging in mice by analyzing the DCE-MRI datasets of mice liver with a dual-input two-compartment tracer kinetic model. Phantom studies were performed to validate the T1 estimates derived by the proposed protocol before applying it in mice studies. The DCE-MRI datasets of mice liver were amendable to tracer kinetic analysis using a dual-input two-compartment model. Estimated micro-circulatory parameters were consistent with liver physiology, indicating viability of applying the technique for pre-clinical drug developments.

Keywords

DCE-MRI, Mouse, Liver Imaging, Preclinical Imaging

Conflicts of Interest

The authors declare no conflicts of interest.

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