Bone Metastases: Experience of Rheumatology Unit of National Hospital University Hubert Koutoukou Maga of Cotonou


Aim: To determine the epidemiological, diagnosis and treatment of secondary bone cancer at the National Hospital University Hubert Koutoukou Maga of Cotonou. Patients and Method: It was a retrospective descriptive cross-sectional study carried out from January 1999 to December 2013 on the records of patients treated in the rheumatology department. The selected files had radiological images of tumor appearance objectified by two radiologists. The diagnosis of secondary bone cancer was confirmed after a bone biopsy or the discovery of a primitive tumor site. Patients with hematologic malignancy and incomplete or insufficiently explored records were excluded. Results: Among 10,292 patients followed in the service, 51 (0.5%) had documented bone metastasis. The sex ratio was 1.83. The mean age of patients was 54 ± 9 [26-85] years, with 53% of those over 60 years old. Secondary cancers were on the spine (74.5%), pelvis (35.3%) and the long bones (39.2%). The primary cancer most frequently found was that of the prostate and breast (45.1% and 27.6%, respectively) followed by genital and digestive cancers (9.8% and 7.8%, respectively). Treatment was dominated by hormone therapy (83%) bisphosphonates (70.5%) and chemotherapy (57%). Conclusion: The profile of bone cancer in Benin hospital is very diverse and dominated by the types and osteolytic ostéocondensant. Primary cancers were dominated by the prostate and breast. Bisphosphonates took an important place in the treatment of the disease.

Share and Cite:

Zomalheto, Z. , Biaou, O. , Yékpè-Ahouansou, P. , Gnankadja, S. and Avimadje, M. (2015) Bone Metastases: Experience of Rheumatology Unit of National Hospital University Hubert Koutoukou Maga of Cotonou. Open Journal of Rheumatology and Autoimmune Diseases, 5, 6-11. doi: 10.4236/ojra.2015.51002.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Lebret, T. and Méjean, A. (2008) Physiopathology, Diagnosis and Management of Bone Metastases from Prostate Cancer. Progrès en Urologie, 18, S349-S356.
[2] Destombe, C., Botton, E., Le Gal, G., Roudaut, A., Jousse, S., Devauchelle, V. and Saraux, A. (2007) Investigations for Bone Metastasis from an Unknown Primary. Joint Bone Spine, 74, 85-89.
[3] Conroy, T., Malissard, L., Dartois, D., Luporsi, E., Stines, J. and Chardot, C. (1988) Natural History and Development of Bone Metastasis. About of 429 Cases. Bulletin du Cancer, 75, 845-857.
[4] Lagrange, J.L., Pan, C., Calitchi, E., Diana, C., Muresan, M., Wu, J.F., et al. (2008) Practical Radiation Therapy for Painful Bone Metastases. Revue Du Rhumatisme, 75, 530-535.
[5] Tubiana-Hulin, M. (1991) Incidence, Prevalence and Distribution of Bone Metastases. Bone, 12, S9-S10.
[6] Oniankitan, O., Kakpovi, K., Kpoti, M., Houzou, P., Fianyo, E., Koffi-Tessio, V.E.S., Tagbor, K.C. and Mijiyawa, M. (2014) Profile of Secondary Bone Cancer in Lomé (Togo). Open Journal of Rheumatology and Autoimmune Diseases, 4, 192-197.
[7] Ntsiba, H., N’soundhat, N.E.L., Ndounga, E. and Ondzal, A.E. (2013) Profile of Secondary Bone Cancer in Brazzaville. Open Journal of Rheumatology and Autoimmune Diseases, 3, 251-254.
[8] Bileckot, R., Miakoundoba, R.C. and Nkoua-Mbon, J.B. (2008) Two Brazzaville Series of Bone Metastases. Carcinol Prat Afrique, 8, 57-60.
[9] Bahebeck, J., Atangana, R., Eyenga, V., et al. (2003) Bones Tumors in Cameroon: Incidence, Demography and Histopathology. International Orthopaedics, 27, 315-317.
[10] Abdulkareem, F.B., Evesan, S.U., Akinde, O.R., et al. (2007) Pathological Studies of Bone Tumors at the National Orthopaedic Hospital, Lagos, Nigeria. Western African Journal of Medicine, 26, 306-311.
[11] Ly, M., Ly, A., Rodrigues, M., et al. (2010) Cancer in Africa, a New Health Challenge. Examples of Mali and Mali Onco Association. Bulletin du Cancer, 97, 965.
[12] Belaksir, L., Seknaji, N., Touimy, M., Janani, S., et al. (2010) Bone Metastases: Experience of Rheumatology CHU Ibn Rushd at Casa. Revue Du Rhumatisme, 77, A131-A325.
[13] Seknaji, N., Touimy, M., Belksir, L., et al. (2010) Contribution of Bone Biopsy in Search of Primary Cancer of Bone Metastases. Revue Du Rhumatisme, 77, A131-A325.
[14] Houze, P., Ranaivosoar, R., Prost, A.C., et al. (1995) Bone Metastases of Prostate Cancer: Contribution of Specific Determination of Bone Alkaline Phosphatase. Immuno-Analyse & Biologie Specialisee, 10, 27-33.
[15] Kouakou, N. (1994) Bone Metastasis in Ivory Coast Hospital. Rhumatologie (Aix-les-Bains) A, 46, 243-245.
[16] Vandecandelaere, M., Filipo, R.M., Cortet, B., Catanzariti, L., Duquesnoy, B. and Delcambre, B. (2004) Bone Metastases Revealing: A Comparative Study in 30-Years Intervals. Revue Du Rhumatisme, 71, 390-396.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.