Design, Realization and Implementation of a Novel Phantom for Quality Control of Micro-SPECT/CT and Micro-PET/CT Systems


The proposed phantom is designed for the quality control of micro-SPECT/CT and micro-PET/CT systems. However, it is an assembly of six patterns stored in a cylindrical box enabling to control both micro-SPECT unit in terms of uniformity, spatial linearity and spatial resolution and micro-CT unit in terms of uniformity, spatial linearity, spatial resolution, diffusion rate, low contrast detectability, Hounsfield unit linearity and slice thickness. The construction material is Plexiglas. As for the implementation, it was made on a micro-SPECT/CT machine of the type “speCZT eXplore CT 120”. Compared to the NEMA NU 4-2008 image quality phantom, this phantom offers micro-CT quality control and is more efficient in control of spatial resolution for micro-SPECT and micro- PET systems.

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Besbes, H. , Krid, R. and Solaiman, B. (2015) Design, Realization and Implementation of a Novel Phantom for Quality Control of Micro-SPECT/CT and Micro-PET/CT Systems. Journal of Biomedical Science and Engineering, 8, 46-55. doi: 10.4236/jbise.2015.81005.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Glover, D.K., Kundu, B. and Schelbert, H.R. (2010) State-of-the-Art Instrumentation for PET and SPECT Imaging in Small Animals. In: Zaret, B.L. and Beller, G.A., Eds., Clinical Nuclear Cardiology: State of the Art and Future Directions, Mosby, Elsevier, Amsterdam, 163-179.
[2] Dillenseger, J.P., Guillaud, B., Goetz, C., Sayeh, A., Schimpf, R., Constantinesco, A. and Choquet, P. (2013) Coregistration of Data Sets from a Micro-SPECT/CT and a Preclinical 1.5T MRI. Nuclear Instruments and Methods in Physics Research A, 702, 144-147.
[3] Lina, K., Liu, H., Hsu, P., Chung, Y., Huang, W., Chen, J., Wey, S., Yen, T. and Hsiao, I. (2009) Quantitative Micro-SPECT/CT for Detecting Focused Ultrasound-Induced Blood-Brain Barrier Opening in the Rat. Nuclear Medicine and Biology, 36, 853-861.
[4] Peremans, K., Vermeire, S., Dobbeleir, A., Gielen, I., Samoy, Y., Piron, K., Vandermeulen, E., Slegers, G., Van Bree, H., De Spiegeleer, B. and Dik, K. (2011) Recognition of Anatomical Predilection Sites in Canine Elbow Pathology on Bone Scans Using Micro-Single Photon Emission Tomography. The Veterinary Journal, 188, 64-72.
[5] Matthews, P.M., Coatney, R., Alsaid, H., Jucker, B., Ashworth, S., Parker, Ch. and Changani, K. (2013) Technologies: Preclinical Imaging for Drug Development. Drug Discovery Today: Technologies. Translational Pharmacology: From Animal to Man and Back, 10, 343-350.
[6] Slavine, N.V. and Antich, P.P. (2008) Practical Method for Radioactivity Distribution Analysis in Small-Animal PET Cancer Studies. Applied Radiation and Isotopes, 66, 1861-1869.
[7] Moran, C.M., Pye, S.D., Ellis, W., Janeczko, A., Morris, K.D., Mcneilly, A.S. and Fraser, H.M. (2011) A Comparison of the Imaging Performance of High Resolution Ultrasound Scanners for Preclinical Imaging. Ultrasound in Medicine & Biology, 37, 493-501.
[8] Jan, M., Ni, Y., Chen, K., Liang, H., Chuang, K. and Fu, Y. (2006) A Combined Micro-PET/CT Scanner for Small Animal Imaging. Nuclear Instruments and Methods in Physics Research A, 569, 314-318.
[9] Habraken, J.B.A., De Bruin, K., Shehata, M., Booij, J., Bennink, R., Van Eck Smit, B.L.F. and Sokole, E.B. (2001) Evaluation of High-Resolution Pinhole SPECT Using a Small Rotating Animal. The Journal of Nuclear Medicine, 42, 1863-1869.
[10] DeWerd, L.A. and Kissick, M. (2014) The Phantoms of Medical and Health Physics: Devices for Research and Development. Springer, Heidelberg.
[11] Busemann Sokole, E. (2003) IAEA Quality Control Atlas for Scintillation Camera Systems. IAEA Library Cataloguing in Publication Data.
[12] International Atomic Energy Agency (2014) PET/CT Atlas on Quality Control and Image Artefacts. IAEA Human Health Series, ISSN 2075-3772, No. 27.
[13] International Atomic Energy Agency (2012) Quality Assurance Programme for Computed Tomography: Diagnostic and Therapy Applications. IAEA Human Health Series, ISSN 2075-3772, No. 19.
[14] Cierniak, R. (2011) X-Ray Computed Tomography in Biomedical Engineering. Springer-Verlag London Limited, London.
[15] Hsieh, H. and Hsiao, I. (2010) Image Reconstructions from Limit Views and Angle Coverage Data for a Stationary Multi-Pinhole SPECT System. Tsinghua Scienece and Technology, 15, 44-49.
[16] Kupinski, M.A. and Barrett, H.H. (2005) Small-Animal SPECT Imaging. Springer Science+Business Media, Inc., Heidelberg.
[17] Seret, A. (2011) NEMA NU1-2001 Performance Tests of four Philips Brightview Cameras. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 648, S89-S92.
[18] Panetta, D., Belcari, N., Del Guerra, A., Bartolomei, A. and Salvadori, P.A. (2012) Analysis of Image Sharpness Reproducibility on a Novel Engineered Micro-CT Scanner with Variable Geometry and Embedded Recalibration Software. Physica Medica, 28, 166-173.
[19] Disselhorst, J.A., Brom, M., Laverman, P., Slump, C.H., Boerman, O.C., Oyen, W.J.G., Gotthardt, M. and Visser, E.P. (2010) Image-Quality Assessment for Several Positron Emitters Using the NEMA NU 4-2008 Standards in the Siemens Inveon Small-Animal PET Scanner. The Journal of Nuclear Medicine, 51, 610-617.
[20] Anizan, N., Carlier, T., Hindorf, C., Barbet, J. and Bardiès, M. (2012) Acquisition Setting Optimization and Quantitative Imaging for 124I Studies with the Inveon MicroPET-CT System. EJNMMI Research, 2, 1-9.

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