Evaluation of a Newly Developed Laser Pen as a Home Care Device for Pain Reduction of Recurrent Aphthous Stomatitis (Preliminary Study)


Objective: The aim of this survey is to evaluate the effect of a new developed laser pen as a home care device for patients’ pain reduction with recurrent aphthous stomatitis. Background data: Recurrent aphthous stomatitis (RAS) is one of the most common and painful ulcers in the oral cavity. Low Level Laser Therapy (LLLT) has been used successfully for reducing pain and healing time in comparison with corticosteroids and placebo in some studies. But these treatments are done in the clinics and it seems that there is no report of the laser treatment as a home care device up to this study. Methods: This was a prospective, randomized trial pilot study. Thirty patients with RAS were divided into three similar groups. The group one (n = 10) was treated with a diode laser, 660 nm, 40 mw, continuous wave, 1.2 J, 6 J/cm2, for five consecutive days (twice per day, 30 seconds each session). The second group (n = 10) was treated with a topical triamcinolone (adcortyl in orabase) ointment four times per day and the third group (n = 10) was treated with placebo (red light pen) the same way as Group 1. All the patients were evaluated with a Visual Analogue Scale (VAS) before and after treatment on the consecutive days. The data was analysed by one way ANOVA and PostHoc tests. Results: The results show that the laser pen and triamcinolon in orabase ointment have similar results and both have better results than placebo in the control of the recurrent aphthous stomatitis pain (p value: 0.001). Conclusion: In this clinical pilot study the laser pen as a home care device seems to be useful for the treatment of RAS.

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Mir, M. , Mojahedi, S. , Adalatkhah, H. , Tunér, J. , Shirani, A. , Babaalipour, R. and Shabani, M. (2015) Evaluation of a Newly Developed Laser Pen as a Home Care Device for Pain Reduction of Recurrent Aphthous Stomatitis (Preliminary Study). International Journal of Clinical Medicine, 6, 19-25. doi: 10.4236/ijcm.2015.61003.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Davatchi, F., Tehrani-Banihashemi, A., Jamshidi, A.R., Chams-Davatchi, C., Gholami, J., Moradi, M., et al. (2008) The Prevalence of Oral Aphthosis in a Normal Population in Iran: A WHO-ILAR COPCORD Study. Archives of Iranian Medicine, 11, 207-209.
[2] Chattopadhyay, A. and Shetty, K.V. (2011) Recurrent Aphthous Stomatitis. Otolaryngologic Clinics of North America, 44, 79-88. http://dx.doi.org/10.1016/j.otc.2010.09.003
[3] Rogers, R.S. (1997) Recurrent Aphthous Stomatitis: Clinical Characteristics and Associated Systemic Disorders. Seminars in Cutaneous Medicine and Surgery, 16, 278-283.
[4] Scully, C. (2012) Aphthous Ulcer. http://emedicine.medscape.com/article/867080-overview
[5] Safavi, S.M., Kazemi, B., Esmaeili, M., Fallah, A., Modarresi, A. and Mir, M. (2008) Effects of Low-Level He-Ne Laser Irradiation on the Gene Expression of IL-1Beta, TNF-Alpha, IFN-Gamma, TGF-Beta, bFGF, and PDGF in Rat’s Gingiva. Lasers in Medical Science, 23, 331-335. http://dx.doi.org/10.1007/s10103-007-0491-5
[6] Pourzarandian, A., Watanabe, H., Ruwanpura, S.M., Aoki, A. and Ishikawa, I. (2005) Effect of Low-Level Er:YAG Laser Irradiation on Cultured Human Gingival Fibroblasts. Journal of Periodontology, 76, 187-193.
[7] Shimizu, N., Yamaguchi, M., Goseki, T., Shibata, Y., Takiguchi, H., Iwasawa, T., et al. (1995) Inhibition of Prostaglandin E2 and Interleukin 1-Beta Production by Low-Power Laser Irradiation in Stretched Human Periodontal Ligament Cells. Journal of Dental Research, 74, 1382-1388.
[8] Mesquita-Ferrari, R.A., Martins, M.D., Silva Jr., J.A., Dias da Silva, T., Piovesan, R.F. and Santos Pavesi, V.C. (2011) Effects of Low-Level Laser Therapy on Expression of TNF-α and TGF-β in Skeletal Muscle during the Repair Process. Lasers in Medical Science, 26, 335-340. http://dx.doi.org/10.1007/s10103-010-0850-5
[9] Niemz, M.H. (2007) Laser-Tissue Interactions. Springer-Verlag, Berlin Heidelberg, 45-149.
[10] Tunér, J. and Beck-Kristensen, P.H. (2011) Low-Level Laser in Dentistry. In: Convissar, R.A., Ed., Principle and Practice of Laser Dentistry, Mosby Elsevier, 263-281.
[11] Tunér, J. and Hode, L. (1998) It’s All in the Parameters: A Critical Analysis of Some Well-Known Negative Studies on Low-Level Laser Therapy. Journal of Clinical Laser Medicine and Surgery, 16, 245-248.
[12] Enwemeka, C.S. (2009) Intricacies of Dose in Laser Phototherapy for Tissue Repair and Pain Relief. Photomedicine and Laser Surgery, 27, 1-7. http://dx.doi.org/10.1089/pho.2009.2503
[13] Mumcu, G., Sur, H., Inanc, N., Karacayli, U., Cimilli, H., Sisman, N., et al. (2009) Composite Index for Determining the Impact of Oral Ulcer Activity in Behcet’s Disease and Recurrent Aphthous Stomatitis. Journal of Oral Pathology & Medicine, 38, 785-791. http://dx.doi.org/10.1111/j.1600-0714.2009.00803.x
[14] De Souza, T.O., Martins, M.A., Bussadori, S.K., Fernandes, K.P., Tanji, E.Y., Mesquita-Ferrari, R.A., et al. (2010) Clinical Evaluation of Low-Level Laser Treatment for Recurring Aphthous Stomatitis. Photomedicine and Laser Surgery, 28, S85-S88. http://dx.doi.org/10.1089/pho.2009.2661
[15] Takahashi, K., Onoda, C., Sugiyama, S., Noro, A., Makiishi, T. and Ishikawa, T. (1987) Clinical Evaluation of Ga-Al-As Semiconductor Laser Diode (UNI-LASER) Irradiation in Treatment of Solitary Aphtha, Erosion and Hyper-sensitive Dentin. Shikwa Gakuho, 87, 295-303.
[16] Quang-Hua, W. and Shi-Yun, P. (1986) Clinical Study of Treatment of Recurrent Aphthae with the (He-Ne) Laser. Actual Odontostomatol (Paris), 40, 327-333.
[17] Prikuls, V.F. (2000) Experience in Irradiating with Helium-Neon Lasers to Treat Patients with Relapsing Aphthous Stomatitis. Stomatologiia (Mosk), 79, 20-22.
[18] von Ahlften, U. (1987) Experiences in the Treatment of Aphthous and Herpetic Oral Mucosal Diseases Using a New Infrared Laser. Quintessenz, 38, 927-933.
[19] Mikha¹lova, R.I., Terekhova, N.V., Zemskaia, E.A. and Melkadze, N. (1992) The Laser Therapy and Laser Acupunture of Patients with Chronic Recurrent Aphthous Stomatitis. Stomatologiia (Mosk), 3, 27-28.
[20] Kruszczyński, T., Kruszczyńska, J., Dziubiński, Z. and Pankowska, B. (1980) Treatment of Recurrent Aphthae by Photocoagulation with an Argon Laser. Czasopismo Stomatologiczne, 33, 787-790.
[21] Khademi, H., Shirani, A.M. and Nikegbal, F. (2009) Evaluation of Low Level Laser Therapy in Recurrent Aphthous Stomatitis. Journal of Dentistry, Shiraz University of Medical Sciences, 10, 160-162.
[22] Tezel, A., Kara, C., Balkaya, V. and Orbak, R. (2009) An Evaluation of Different Treatments for Recurrent Aphthous Stomatitis and Patient Perceptions: Nd:YAG Laser versus Medication. Photomedicine and Laser Surgery, 27, 101-106.
[23] Demetriades, N., Hanford, H. and Laskarides, C. (2009) General Manifestations of Behçet’s Syndrome and the Success of CO2-Laser as Treatment for Oral Lesions: A Review of the Literature and Case Presentation. Journal of the Massachusetts Dental Society, 58, 24-27.
[24] Salman, H., Kashmoola, M.A., AL-Waez, M.M. and AL-Sandooq, T.A. (2008) Differences between Low Level Laser Therapy and Triamcinolone Acetonide Kenalog on Healing of Recurrent Aphthous Ulceration. Annals of the College of Medicine Mosul, 34, 35-41.
[25] Kashmoola, M.A., Salman, H. and AL-Waez, M.M. (2005) Clinical Effect of Low Level Laser Therapy on Healing of Recurrent Aphthous Ulcer and Oral Ulceration in Behcet’s Disease. Journal of Baghdad College of Dentistry, 172, 36-40.
[26] Colvard, M. and Kuo, P. (1991) Managing Aphthous Ulcers: Laser Treatment Applied. Journal of the American Dental Association, 122, 51-53.
[27] Caputo, B.V., Filho, G.A.N., dos Santos, C.C., Okida, Y. and Giovani, E.M. (2012) Laser Therapy of Recurrent Aphthous Ulcer in Patient with HIV Infection. Case Reports in Medicine, 1-3.
[28] Albrektson, M. and Marklund, B. (2012) Can Low Level Laser Therapy Relieve Acute Symptoms of Recurrent Aphthous Stomatitis—A Randomized Clinical Study. Medicina Oral Patología Oral y Cirugia Bucal, 17, S263.
[29] Bladowski, M., Konarska-Choroszucha, H. and Choroszucha, T. (2004) Comparison of Treatment Results of Recurrent Aphthous Stomatitis with Low and High Power Laser Irradiation vs. a Pharmaceutical Method (5-Year Study). The Journal of Oral Laser Applications, 4, 191-209.
[30] Zand, N., Fateh, M., Ataie-Fashtami, L., Djavid, G.E., Fatemi, S.M. and Shirkavand, A. (2012) Promoting Wound Healing in Minor Recurrent Aphthous Stomatitis by Non-Thermal, Non-Ablative CO2 Laser Therapy: A Pilot Study. Photomedicine and Laser Surgery, 30, 719-723. http://dx.doi.org/10.1089/pho.2012.3301
[31] Zand, N., Ataie-Fashtami, L., Djavid, G.E., Fateh, M., Alinaghizadeh, M.R., Fatemi, S.M., et al. (2009) Relieving Pain in Minor Aphthous Stomatitis by a Single Session of Non-Thermal Carbon Dioxide Laser Irradiation. Lasers in Medical Science, 24, 515-520. http://dx.doi.org/10.1007/s10103-008-0555-1
[32] Basirat, M. (2012) The Effects of the Low Power Lasers in the Healing of the Oral Ulcers. Journal of Lasers in Medical Sciences, 3, 79-83.
[33] Sanchez, P.J.M., Femenias, J.L.C. and Tunér, J. (2013) Treatment of Aphthous Stomatitis Using Low Level Laser Therapy. Laser, 3, 18-20.
[34] da Silva, J.P., da Silva, M.A., Almeida, A.P.F., Lomdardi, I. and Matos, A.P.M. (2010) Laser Therapy in the Tissue Repair Process: A Literature Review. Photomedicine and Laser Surgery, 28, 17-21.
[35] Howell, R.M., Cohen, D.M., Lynn Powell, G. and Green, J.G. (1988) The Use of Low Energy Laser Therapy to Treat Aphthous Ulcers. Annals of Dentistry, 47, 16-18.
[36] Albrektson, M., Hedström, L. and Bergh, H. (2014) Recurrent Aphthous Stomatitis and Pain Management with Low-Level Laser Therapy: A Randomized Controlled Trial. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 117, 590-594. http://dx.doi.org/10.1016/j.oooo.2014.01.228
[37] Enwemeka, C.S., Parker, J.C., Dowdy, D., Harkness, E.E., Sanford, L. and Woodruff, L.D. (2004) The Efficacy of Low-Power Lasers in Tissue Repair and Pain Control: A Meta-Analysis Study. Photomedicine and Laser Surgery, 22, 323-329. http://dx.doi.org/10.1089/pho.2004.22.323
[38] Woodruff, L.D., Bounkeo, J.M., Brannon, W.M., Dawes, K.S., Barham, C.D., Waddell, D.L. and Enwemeka, C.S. (2004) The Efficacy of Laser Therapy in Wound Repair: A Meta-Analysis of the Literature. Photomedicine and Laser Surgery, 22, 241-247. http://dx.doi.org/10.1089/1549541041438623

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