A Structure and Antioxidant Activity Study of Paracetamol and Salicylic Acid
Rosivaldo S. Borges1*, Tainá G. Barros1, Glaécia A. N. Pereira1, João Batista Jr.1, Raimundo F. G. P. Beleza Filho1, Andrex A. S. Veiga1, Moisés Hamoy2, Vanessa J. Mello2, Albérico B. F. da Silva3, Carlos A. L. Barros1
1Núcleo de Estudos e Seleção de Moléculas Bioativas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil.
1Núcleo de Estudos e Seleção de Moléculas Bioativas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil.
2Laboratório de Farmacologia e Toxicologia de Produtos Naturais, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil.
3Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, Brazil.
DOI: 10.4236/pp.2014.513130   PDF   HTML   XML   4,985 Downloads   6,892 Views   Citations


The paracetamol has more antioxidant properties than the salicylic acid on the several oxidative stress-forced models and one possible mechanism is due to electron or hydrogen transfer by the evaluated hydroxyl radicals. The antioxidant mechanism for the compounds studied here was performed by molecular modeling using quantum chemical calculations at the B3LYP level of theory. Our results show that the paracetamol has more antioxidant properties than the salicylic acid in experimental and theoretical studies. The theoretical mechanism show that the hydrogen transfer is more favorable than the electron transfer. From the study it was concluded that the electron abstraction for paracetamol is more favored than salicylic acid.

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Borges, R. , Barros, T. , Pereira, G. , Batista Jr., J. , Beleza Filho, R. , Veiga, A. , Hamoy, M. , Mello, V. , Silva, A. and Barros, C. (2014) A Structure and Antioxidant Activity Study of Paracetamol and Salicylic Acid. Pharmacology & Pharmacy, 5, 1185-1191. doi: 10.4236/pp.2014.513130.

Conflicts of Interest

The authors declare no conflicts of interest.


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