Cholangiocarcinoma in Patients with Crohn’s Disease

Tarek Debs, Isabella Reccia^*, Imad El-Hajj, Ziad El-Rassi

Division of General and Visceral Surgery, Saint George Hospital University Medical Centre, Beirut, Lebanon.

DOI: 10.4236/jct.2015.61003                

Abstract

Cholangiocarcinoma is an uncommon malignancy that increases with age. Cholangiocarcinoma has been linked to inflammatory bowel disease, and a relationship between inflammatory bowel disease, anti-tumour necrosis factor alpha antibody (Infliximab) and cholangiocarcinoma has been suggested. Although cholangiocarcinoma is usually associated with ulcerative colitis, recently more cases are being seen in association with Crohn’s disease. The risk of cancer in patients treated with Infliximab has been discussed, and whether Infliximab is associated with an increased risk of cholangiocarcinoma is not clear. Cholangiocarcinoma is an uncommon malignancy and it is difficult to establish a clear correlation with Infliximab treatment. A large number of reports are needed to further address these issues. 

Keywords

Cholangiocarcinoma, Crohn’s, Inflammatory Bowel Disease, Infliximab

Conflicts of Interest

The authors declare no conflicts of interest.

References

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[33]	Altaee, M.Y., Johnson, P.J., Farrant, J.M. and Williams, R. (1991) Etiologic and Clinical Characteristics of Peripheral and Hilar Cholangiocarcinoma. Cancer, 68, 2051-2055. http://dx.doi.org/10.1002/1097-0142(19911101)68:9<2051::AID-CNCR2820680934>3.0.CO;2-M
[34]	Choi, P.M., Nugent, F.W., Zelig, M.P., Munson, J.L. and Schoetz Jr., D.J. (1994) Cholangiocarcinoma and Crohn’s Disease. Digestive Diseases and Sciences, 39, 667-670. http://dx.doi.org/10.1007/BF02088359