Gender Does Not Have a Potential Predictive Value for the Presence of Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinoma


Background: Previous studies reported that non-small cell carcinoma patients characterized by female gender, never-smoking status and adenocarcinoma histology were more likely to harbor epidermal growth factor receptor (EGFR) mutations. However, some studies failed to find the relationship between EGFR mutation and gender. Methods: One hundred and eighty-four consecutive patients (90 men and 94 women) of resected lung adenocarcinoma were studied retrospectively. Since the smoking rate is significantly higher in men, we assumed that gender difference might be a seeming factor affected by smoking. Therefore we subdivided the patients into 2 groups: never- and ever-smokers. Results: The number of ever-smokers was 94.44% in men, whereas 8.51% in women. EGFR mutation was positive in 48.9%. For overall patients, EGFR mutation status was associated with gender, pStage, pT status, lepidic dominant histologic subtype, pure/mixed groundglass opacity (GGO) on computed tomography (CT) and smoking status. However, in ever-smokers, EGFR mutation status was associated with lepidic histologic subtype and GGO on CT, but not others including gender. Similar results were also found in never-smokers, and gender was not also related to EGFR mutation in never smokers. Conclusion: The EGFR mutational frequency among men and women was not significantly different when lung adenocarcinoma patients were stratified into never- and ever-smokers.


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Tomita, M. , Ayabe, T. , Chosa, E. , Kawagoe, K. and Nakamura, K. (2014) Gender Does Not Have a Potential Predictive Value for the Presence of Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinoma. Advances in Lung Cancer, 3, 82-87. doi: 10.4236/alc.2014.34012.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Olayioye, M.A., Neve, R.M., Lane, H.A. and Hynes, N.E. (2000) The ErbB Signaling Network: Receptor Heterodimerization in Development and Cancer. The EMBO Journal, 19, 3159-3167.
[2] Pinkas-Kramarski, R., Soussan, L., Waterman, H., Levkowitz, G., Alroy, I., Klapper, L., Lavi, S., Seger, R., Ratzkin, B.J., Sela, M. and Yarden, Y. (1996) Diversification of Neu Differentiation Factor and Epidermal Growth Factor Signaling by Combinatorial Receptor Interactions. The EMBO Journal, 15, 2452-2467.
[3] Lynch, T.J., Bell, D.W., Sordella, R., Gurubhagavatula, S., Okimoto, R.A., Brannigan, B.W., Harris, P.L., Haserlat, S.M., Supko, J.G., Haluska, F.G., Louis, D.N., Christiani, D.C., Settleman, J. and Haber, D.A. (2004) Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib. The New England Journal of Medicine, 350, 2129-2139.
[4] Kosaka, T., Yatabe, Y., Endoh, H., Kuwano, H., Takahashi, T. and Mitsudomi, T. (2004) Mutations of the Epidermal growth Factor Receptor Gene in Lung Cancer: Biological and Clinical Implications. Cancer Research, 64, 8919-8923.
[5] Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, I.I., Fong, K.M., Lee, H., Toyooka, S., Shimizu, N., Fujisawa, T., Feng, Z., Roth, J.A., Herz, J., Minna, J.D. and Gazdar, A.F. (2005) Clinical and Biological Features Associated with Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers. Journal of the National Cancer Institute, 97, 339-346.
[6] Mitsudomi, T., Kosaka, T. and Yatabe, Y. (2006) Biological and Clinical Implications of EGFR Mutations in Lung Cancer. International Journal of Clinical Oncology, 11, 190-198.
[7] D’Angelo, S.P., Pietanza, M.C., Johnson, M.L., Riely, G.J., Miller, V.A., Sima, C.S., Zakowski, M.F., Rusch, V.W., Ladanyi, M. and Kris, M.G. (2011) Incidence of EGFR Exon 19 Deletions and L858R in Tumor Specimens from Men and Cigarette Smokers with Lung Adenocarcinomas. Journal of Clinical Oncology, 29, 2066-2070.
[8] Hsiao, S.H., Lin, S.E., Chou, Y.T., Wang, J.L., Chung, C.L., Yu, M.C., Fang, C.L., Lee, H.L., Chiang, L.L., Liu, H.E. and Wu, C.W. (2014) Histological Subtype and Smoking Status, But Not Gender, Are Associated with Mutations in Non-Small-Cell Lung Cancer. Molecular and Clinical Oncology, 2, 252-258.
[9] Tanaka, T., Matsuoka, M., Sutani, A., Gemma, A., Maemondo, M., Inoue, A., Okinaga, S., Nagashima, M., Oizumi, S., Uematsu, K., Nagai, Y., Moriyama, G., Miyazawa, H., Ikebuchi, K., Morita, S., Kobayashi, K. and Hagiwara, K. (2010) Frequency of and Variables Associated with the EGFR Mutation and Its Subtypes. International Journal of Cancer, 126, 651-655.
[10] Yatabe, Y., Hida, T., Horio, Y., Kosaka, T., Takahashi, T. and Mitsudomi, T. (2006) A Rapid, Sensitive Assay to Detect EGFR Mutation in Small Biopsy Specimens from Lung Cancer. The Journal of Molecular Diagnostics, 8, 335-341.
[11] Brinkman, G.L. and Coates Jr., E.O. (1963) The Effect of Bronchitis, Smoking, and Occupation on Ventilation. The American Review of Respiratory Disease, 87, 684-693.
[12] Travis, W.D., Brambilla, E., Noguchi, M., Nicholson, A.G., Geisinger, K.R., Yatabe, Y., Beer, D.G., Powell, C.A., Riely, G.J., Van Schil, P.E., Garg, K., Austin, J.H., Asamura, H., Rusch, V.W., Hirsch, F.R., Scagliotti, G., Mitsudomi, T., Huber, R.M., Ishikawa, Y., Jett, J., Sanchez-Cespedes, M., Sculier, J.P., Takahashi, T., Tsuboi, M., Vansteenkiste, J., Wistuba, I., Yang, P.C., Aberle, D., Brambilla, C., Flieder, D., Franklin, W., Gazdar, A., Gould, M., Hasleton, P., Henderson, D., Johnson, B., Johnson, D., Kerr, K., Kuriyama, K., Lee, J.S., Miller, V.A., Petersen, I., Roggli, V., Rosell, R., Saijo, N., Thunnissen, E., Tsao, M. and Yankelewitz, D. (2011) International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma. Journal of Thoracic Oncology, 6, 244-285.
[13] Lee, H.J., Kim, Y.T., Kang, C.H., Zhao, B., Tan, Y., Schwartz, L.H., Persigehl, T., Jeon, Y.K. and Chung, D.H. (2013) Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinomas: Relationship with CT Characteristics and Histologic Subtypes. Radiology, 268, 254-264.
[14] Hsieh, R.K., Lim, K.H., Kuo, H.T., Tzen, C.Y. and Huang, M.J. (2005) Female Sex and Bronchioloalveolar Pathologic Subtype Predict EGFR Mutations in Non-Small Cell Lung Cancer. Chest, 128, 317-321.
[15] Yano, M., Sasaki, H., Kobayashi, Y., Yukiue, H., Haneda, H., Suzuki, E., Endo, K., Kawano, O., Hara, M. and Fujii, Y. (2006) Epidermal Growth Factor Receptor Gene Mutation and Computed Tomographic Findings in Peripheral Pulmonary Adenocarcinoma. Journal of Thoracic Oncology, 1, 413-416.
[16] Ambrosini-Spaltro, A., Ruiu, A., Seebacher, C., Vattemi, E., Gentile, L., Feil, B., Zaraca, F. and Carella, R. (2014) Impact of the IASLC/ATS/ERS Classification in pN0 Pulmonary Adenocarcinomas: A Study with Radiological-Pathological Comparisons and Survival Analyses. Pathology, Research and Practice, 210, 40-46.

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