Nutrigenomic Study on Immunomodulatory Function of Cordyceps Mycelium Extract (Paecilomyces hepiali) in Mitomycin C–Treated Mice

Soo-Wan Chae^1,2, Fusako Mitsunaga^3,4, Su-Jin Jung², Ki-Chan Ha⁵, Hong-Sig Sin⁶, Seung-Hwan Jang⁶, Shin Nakamura^3.4

¹Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Republic of Korea.
²Clinical Trial Center for Functional Foods (CTCF2), Chonbuk National University Hospital, Jeonju, Republic of Korea.
³Intelligence and Technology Lab Inc., Kaizu, Japan.
⁴NPO Primate Agora, Inuyama, Japan.
⁵Healthcare Claims & Management Inc., Jeonju, Republic of Korea.
⁶Chebigen Inc., Jeonju, Republic of Korea.

DOI: 10.4236/fns.2014.522235                

Abstract

Cordyceps (CS) is a Chinese herb that produces various effects including immune modulation, and now CS culture product is interested in the use as a functional food. We prepared CS mycelium culture extract (Paecilomyces hepiali, CBG-CS-2), CS extract, for functional foods. This study aimed to deduce the molecular mechanism of immunomodulatory effect of CS extract in Peyer’s patches (PPs), a main gut immune site, in mice that treated with mitomycin C (MMC), an immunosuppressing antibiotics. Nutrigenomics give us invaluable molecular information about both of foods and nutrition to improve or maintain good health. Here we performed nutrigenomics using DNA microarray to investigate the effect of CS extract on gene expression altered in PPs of the immunosuppressed mice. Interestingly, CS extract protected from the MMC-mediated downregulation of 22 genes, which are associated with IgA production and other immune response in PPs. These suggested that CS extract alleviated the downregulated expression of immune related genes in the gut immune site in an immunosuppressed state. Thus CS extract appears to be practical functional food for immunodepression and/or its related hypofunction.

Keywords

DNA Microarray, Functional Food, Gene Expression, Immunosuppression

Conflicts of Interest

The authors declare no conflicts of interest.

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