|
[1]
|
Boyer, J.S. (1982) Plant Productivity and Environment. Science, 218, 443-448.
http://dx.doi.org/10.1126/science.218.4571.443
|
|
[2]
|
Vinocur, B. and Altman, A. (2005) Recent Advances in Engineering Plant Tolerance to Abiotic Stress: Achievements and Limitations. Current Opinion in Biotechnology, 16, 123-132. http://dx.doi.org/10.1016/j.copbio.2005.02.001
|
|
[3]
|
Ingram, J. and Bartels, D. (1996) The Molecular Basis of Dehydratation Tolerance in Plants. Annual Review of Plant Physiology and Plant Molecular Biology, 47, 377-403. http://dx.doi.org/10.1146/annurev.arplant.47.1.377
|
|
[4]
|
Blum, A. (2011) The Interdrought Conference in Perspective. Journal of Experimental Botany.
|
|
[5]
|
Bray, E. (1993) Molecular Responses to Water Deficit. Plant Physiology, 103, 1035-1040.
|
|
[6]
|
Cramer, G.R., Urano, K., Delrot, S., Pezzotti, M. and Shinozaki, K. (2011) Effects of Abiotic Stress on Plants: A Systems Biology Perspective. BMC Plant Biology, 11, 163. http://dx.doi.org/10.1186/1471-2229-11-163
|
|
[7]
|
Raghavendra, A.S., Gonugunta, V.K., Christmann, A. and Grill, E. (2010) ABA Perception and Signalling. Trends in Plant Science, 15, 395-401. http://dx.doi.org/10.1016/j.tplants.2010.04.006
|
|
[8]
|
Ahuja, I., de Vos, R.C., Bones, A.M. and Hall, R.D. (2010) Plant Molecular Stress Responses Face Climate Change. Trends in Plant Sciences, 15, 664-674. http://dx.doi.org/10.1016/j.tplants.2010.08.002
|
|
[9]
|
Xiong, L., Schumaker, K.S. and Zhu, J.K. (2002) Cell Signaling during Cold, Drought, and Salt Stress. The Plant Cell Online, 14, S165-S183.
|
|
[10]
|
Yamaguchi-Shinozaki, K. and Shinozaki, K. (2006) Transcriptional Regulatory Networks in Cellular Responses and Tolerance to Dehydration and Cold Stresses. Annual Review of Plant Biology, 57, 781-803.
http://dx.doi.org/10.1146/annurev.arplant.57.032905.105444
|
|
[11]
|
Cacela, C. and Hincha, D.K. (2006) Monosaccharide Composition, Chain Length and Linkage Type Influence the Interactions of Oligosaccharides with Dry Phosphatidylcholine Membranes. Biochimica et Biophysica Acta (BBA)— Biomembranes, 1758, 680-691. http://dx.doi.org/10.1016/j.bbamem.2006.04.005
|
|
[12]
|
Amara, I., Capellades, M., Ludevid, M.D., Pagès, M. and Goday, A. (2013) Enhanced Water Stress Tolerance of Transgenic Maize Plants Over-Expressing LEA Rab28 Gene. Journal of Plant Physiology, 170, 864-873.
http://dx.doi.org/10.1016/j.jplph.2013.01.004
|
|
[13]
|
Liang, J., Zhou, M., Zhou, X., Jin, Y., Xu, M. and Lin, J. (2013) JcLEA, a Novel LEA-Like Protein from Jatropha curcas, Confers a High Level of Tolerance to Dehydration and Salinity in Arabidopsis thaliana. PLoS ONE, 8, e83056.
http://dx.doi.org/10.1371/journal.pone.0083056
|
|
[14]
|
Dure, L., Greenway, S. and Galau, G. (1981) Developmental Biochemistry of Cotton Seed Embryogenesis and Germination: Changing Messenger Ribonucleic Acid Populations as Shown by in Vitro and in Vivo Protein Synthesis. Biochemistry, 20, 4162-4168. http://dx.doi.org/10.1021/bi00517a033
|
|
[15]
|
Galau, G.A., Hughes, D.W. and Dure, L. (1986) Abscisic Acid Induction of Cloned Cotton Late Embryogenesis-Abundant (Lea) mRNAs. Plant Molecular Biology, 7, 155-170. http://dx.doi.org/10.1007/BF00021327
|
|
[16]
|
Baker, J., Steele, C. and Dure, L. (1988) Sequence and Characterization of 6 Lea Proteins and Their Genes from Cotton. Plant Molecular Biology, 11, 277-291. http://dx.doi.org/10.1007/BF00027385
|
|
[17]
|
Bies-Etheve, N., Gaubier-Comella, P., Debures, A., Lasserre, E., Jobet, E., Raynal, M., Cooke, R. and Delseny, M. (2008) Inventory, Evolution and Expression Profiling Diversity of the LEA (Late Embryogenesis Abundant) Protein Gene Family in Arabidopsis thaliana. Plant Molecular Biology, 67, 107-124.
http://dx.doi.org/10.1007/s11103-008-9304-x
|
|
[18]
|
Hundertmark, M. and Hincha, D.K. (2008) LEA (Late Embryogenesis Abundant) Proteins and Their Encoding Genes in Arabidopsis thaliana. BMC Genomics, 9, 118. http://dx.doi.org/10.1186/1471-2164-9-118
|
|
[19]
|
Battaglia, M., Olvera-Carrillo, Y., Garciarrubio, A., Campos, F. and Covarrubias, A.A. (2008) The Enigmatic LEA Proteins and Other Hydrophilins. Plant Physiology, 148, 6-24. http://dx.doi.org/10.1104/pp.108.120725
|
|
[20]
|
Hand, S.C., Menze, M.A., Toner, M., Boswell, L. and Moore, D. (2011) LEA Proteins during Water Stress: Not Just for Plants Anymore. Annual Review of Physiology, 73, 115-134.
http://dx.doi.org/10.1146/annurev-physiol-012110-142203
|
|
[21]
|
Goldberg, R.B., Barker, S.J. and Perez-Grau, L. (1989) Regulation of Gene Expression during Plant Embryogenesis. Cell, 56, 149-160. http://dx.doi.org/10.1016/0092-8674(89)90888-X
|
|
[22]
|
Skriver, K. and Mundy, J. (1990) Gene Expression in Response to Abscisic Acid and Osmotic Stress. Plant Cell, 2, 503-512. http://dx.doi.org/10.1105/tpc.2.6.503
|
|
[23]
|
Cuming, A. (1999) LEA Proteins. In: Casey, R. and Shewry, P.R., Eds., Seed Proteins, Kluwer Academic Publishers, Dordrecht, 753-780. http://dx.doi.org/10.1007/978-94-011-4431-5_32
|
|
[24]
|
Dure, L., Crouch, M., Harada, J., Ho, T.H., Mundy, J., Quatrano, R., Thomas, T. and Sung, Z. (1989) Common Amino Acid Sequence Domains among the LEA Proteins of Higher Plants. Plant Molecular Biology, 12, 475-486.
http://dx.doi.org/10.1007/BF00036962
|
|
[25]
|
Bartels, D. and Sunkar, R. (2005) Drought and Salt Tolerance in Plants. Critical Reviews in Plant Sciences, 24, 23-58.
http://dx.doi.org/10.1080/07352680590910410
|
|
[26]
|
Alpert, P. (2005) The Limits and Frontiers of Desiccation-Tolerant Life. Integrative and Comparative Biology, 45, 685-695. http://dx.doi.org/10.1093/icb/45.5.685
|
|
[27]
|
Oliver, M.J., Tuba, Z. and Mishler, B.D. (2000) The Evolution of Vegetative Desiccation Tolerance in Land Plants. Plant Ecology, 151, 85-100. http://dx.doi.org/10.1023/A:1026550808557
|
|
[28]
|
Oliver, R.P. and Solomon, P.S. (2004) Does the Oxidative Stress Used by Plants for Defence Provide a Source of Nutrients for Pathogenic Fungi? Trends in Plant Science, 9, 472-473. http://dx.doi.org/10.1016/j.tplants.2004.08.006
|
|
[29]
|
Reynolds, T.L.B. and Derek, J. (1993) Abscisic Acid Enhances the Ability of the Desiccation-Tolerant Fern Polypodium virginianum to Withstand Drying. Journal of Experimental Botany, 44, 1771-1779.
http://dx.doi.org/10.1093/jxb/44.12.1771
|
|
[30]
|
Honjoh, K.I., Yoshimoto, M., Joh, T., Kajiwara, T., Miyamoto, T. and Hatano, S. (1995) Isolation and Characterization of Hardening-Induced Proteins in Chlorella vulgaris C-27: Identification of Late Embryogenesis Abundant Proteins. Plant and Cell Physiology, 36, 1421-1430.
|
|
[31]
|
Shih, M.D., Hoekstra, F.A. and Hsing, Y.I.E. (2008) Late Embryogenesis Abundant Proteins. Advances in Botanical Research, 48, 212-240. http://dx.doi.org/10.1016/S0065-2296(08)00404-7
|
|
[32]
|
Garay-Arroyo, A. Colmenero-Flores, J., Garciarrubio, A. and Covarrubias, A.A. (2000) Highly Hydrophilic Proteins in Prokaryotes and Eukaryotes Are Common during Conditions of Water Deficit. Journal of Biological Chemistry, 275, 5668-5674. http://dx.doi.org/10.1074/jbc.275.8.5668
|
|
[33]
|
Stacy, R.A.P., Nordeng, T.W., Francisco, A. and Aalen, R.B. (1999) The Dormancy Related Peroxiredoxin Anti-Oxidant, PER1, Is Localized to the Nucleus of Barley Embryo and Aleurone Cells. The Plant Journal, 19, 1-8.
http://dx.doi.org/10.1046/j.1365-313X.1999.00488.x
|
|
[34]
|
Abba, S., Ghignon, S. and Bonfante, P. (2006) A Dehydration-Inducible Gene in the Truffle Tuber borchii Identifies a Novel Group of Dehydrins. BMC Genomics, 7, 39. http://dx.doi.org/10.1186/1471-2164-7-39
|
|
[35]
|
Borovskii, G.B., Stupnikova, I.V., Antipina, A.I., Downs, C.A. and Voinikov, V.K. (2000) Accumulation of Dehydrin-Like-Proteins in the Mitochondria of Cold-Treated Plants. Journal of Plant Physiology, 156, 797-800.
http://dx.doi.org/10.1016/S0176-1617(00)80250-3
|
|
[36]
|
Solomon, A., Salomon, R., Paperna, I. and Glazer, I. (2000) Desiccation Stress of Entomopathogenic Nematodes Induces the Accumulation of a Novel Heat-Stable Protein. Parasitology, 121, 409-416.
http://dx.doi.org/10.1017/S0031182099006563
|
|
[37]
|
Browne, J.A., Dolan, K.M., Tyson, T., Goyal, K., Tunnacliffe, A. and Burnell, A.M. (2004) Dehydration-Specific Induction of Hydrophilic Protein Genes in the Anhydrobiotic Nematode Aphelenchus avenae. Eukaryotic Cell, 3, 966-975. http://dx.doi.org/10.1128/EC.3.4.966-975.2004
|
|
[38]
|
Hoekstra, F.A., Golovina, E.A. and Buitink, J. (2001) Mechanisms of Plant Desiccation Tolerance. Trends in Plant Science, 6, 431-438. http://dx.doi.org/10.1016/S1360-1385(01)02052-0
|
|
[39]
|
Tunnacliffe, A. and Wise, M. (2007) The Continuing Conundrum of the LEA Proteins. Naturwissenschaften, 94, 791-812. http://dx.doi.org/10.1007/s00114-007-0254-y
|
|
[40]
|
Battaglia, M. and Covarrubias, A.A. (2013) Late Embryogenesis Abundant (LEA) Proteins in Legumes. Front Plant Science, 25, 190.
|
|
[41]
|
Tunnacliffe, A., Lapinski, J. and McGee, B. (2005) A Putative LEA Protein, but No Trehalose, Is Present in Anhydrobiotic Bdelloid rotifers. Hydrobiologia, 546, 315-321. http://dx.doi.org/10.1007/s10750-005-4239-6
|
|
[42]
|
Hunault, G. and Jaspard, E. (2010) LEAPdb: A Database for the Late Embryogenesis Abundant Proteins. BMC Genomics, 11, 221. http://dx.doi.org/10.1186/1471-2164-11-221
|
|
[43]
|
Jaspard, E., Macherel, D. and Hunault, G. (2012) Computational and Statistical Analyses of Amino Acid Usage and Physico-Chemical Properties of the Twelve Late Embryogenesis Abundant Protein Classes. PLoS ONE, 7, 1-5.
http://dx.doi.org/10.1371/journal.pone.0036968
|
|
[44]
|
Galau, G.A., Hughes, D.W. and Dure, L. (1986) Abscisic Acid Induction of Cloned Cotton Late Embryogenesis-Abundant (Lea) mRNAs. Plant Molecular Biology, 7, 155-170. http://dx.doi.org/10.1007/BF00021327
|
|
[45]
|
Goday, A., Sánchez-Martínez, D., Gómez, J., Domènech, P.P. and Pagès, M. (1988) Gene Expression in Developing Zea mays Embryos: Regulation by Abscisic Acid of a Highly Phosphorylated 23- to 25-kD Group of Proteins. Plant Physiology, 88, 564-569. http://dx.doi.org/10.1104/pp.88.3.564
|
|
[46]
|
Campos, F., Cuevas-Velazquez, C., Fares, M., Reyes, J.L. and Covarrubias, A.A. (2013) Group 1 LEA Proteins, an Ancestral Plant Protein Group, Are Also Present in Other Eukaryotes, and in the Archeae and Bacteria Domains. Molecular Genetics & Genomics, 288, 503-517. http://dx.doi.org/10.1007/s00438-013-0768-2
|
|
[47]
|
Amara, I., Odena, A., Oliveira, E., Moreno, A., Masmoudi, K., Pagès, M. and Goday, A. (2012) Insights into Maize LEA Proteins: From Proteomics to Functional Approaches. Plant Cell Physiology, 53, 312-329.
http://dx.doi.org/10.1093/pcp/pcr183
|
|
[48]
|
Wu, X., Gong, F. and Wang, W. (2013) Functional Assignment to Maize Group 1 LEA Protein EMB564 within the Cell Nucleus Using Computational Analysis. Bioinformation, 9, 276-280. http://dx.doi.org/10.6026/97320630009276
|
|
[49]
|
Campbell, S.A. and Close, T.J. (1997) Dehydrins: Genes, Proteins, and Associations with Phenotypic Traits. New Phytologist, 137, 61-74. http://dx.doi.org/10.1046/j.1469-8137.1997.00831.x
|
|
[50]
|
Campbell, S.A., Crone, D.E., Ceccardi, T.L. and Close, T.J. (1998) A ca. 40 kDa Maize (Zea mays L.) Embryo Dehydrin Is Encoded by the Dhn2 Locus on Chromosome 9. Plant Molecular Biology, 38, 417-423.
http://dx.doi.org/10.1023/A:1006037308167
|
|
[51]
|
Close, T. (1996) Dehydrins: Emergence of a Biochemical Role of a Family of Plant Dehydration Proteins. Physiologia Plantarum, 97, 795-803. http://dx.doi.org/10.1111/j.1399-3054.1996.tb00546.x
|
|
[52]
|
Drira, M., Saibi, W., Brini, F., Gargouri, A., Masmoudi, K. and Hanin, M. (2013) The K-Segments of the Wheat Dehydrin DHN-5 Are Essential for the Protection of Lactate Dehydrogenase and β-Glucosidase Activities in Vitro. Molecular Biotechnology, 2, 643-650. http://dx.doi.org/10.1007/s12033-012-9606-8
|
|
[53]
|
Scott, A.C. and Close, T.J. (1997) Dehydrins: Genes, Proteins, and Associations with Phenotypic Traits. New Phytologist, 137, 61-74. http://dx.doi.org/10.1046/j.1469-8137.1997.00831.x
|
|
[54]
|
Vaseva, I.I., Anders, I. and Feller, U. (2013) Identification and Expression of Different Dehydrin Subclasses Involved in the Drought Response of Trifolium repens. Journal of Plant Physiology, 171, 213-224.
|
|
[55]
|
Dure, L. (1993) A Repeating 11-Mer Amino Acid Motif and Plant Desiccation. The Plant Journal, 3, 363-369.
http://dx.doi.org/10.1046/j.1365-313X.1993.t01-19-00999.x
|
|
[56]
|
Battista, J., Park, M.J. and McLemore, A. (2001) Inactivation of Two Homologues of Proteins Presumed to Be Involved in the Desiccation Tolerance of Plants Sensitizes Deinococcus radiodurans R1 to Desiccation. Cryobiology, 43, 133-139. http://dx.doi.org/10.1006/cryo.2001.2357
|
|
[57]
|
Dure, L. (2001) Occurrence of a Repeating 11-Mer Amino Acid Sequence Motif in Diverse Organisms. Protein and Peptide Letters, 8, 115-122. http://dx.doi.org/10.2174/0929866013409643
|
|
[58]
|
Gal, T., Glazer, I. and Koltai, H. (2004) An LEA Group 3 Family Member Is Involved in Survival of C. elegans during Exposure to Stress. FEBS Letters, 577, 21-26. http://dx.doi.org/10.1016/j.febslet.2004.09.049
|
|
[59]
|
Boswell, L.C., Moore, D.S. and Hand, S.C. (2013) Quantification of Cellular Protein Expression and Molecular Features of Group 3 LEA Proteins from Embryos of Artemia franciscana. Cell Stress Chaperones, 19, 329-341.
http://dx.doi.org/10.1007/s12192-013-0458-3
|
|
[60]
|
Tunnacliffe, A., Hincha, D., Leprince, O. and Macherel, D. (2010) LEA Proteins: Versatility of Form and Function. In: Lubzens, E., Cerda, J. and Clark, M., Eds., Dormancy and Resistance in Harsh Environments, Springer, Heidelberg, 91-108. http://dx.doi.org/10.1007/978-3-642-12422-8_6
|
|
[61]
|
Wise, M.J. and Tunnacliffe, A. (2004) POPP the Question: What Do LEA Proteins Do? Trends in Plant Science, 9, 13-17. http://dx.doi.org/10.1016/j.tplants.2003.10.012
|
|
[62]
|
Hand, S., Jones, D., Menze, M. and Witt, T. (2007) Life without Water: Expression of Plant LEA Genes by an Anhydrobiotic Arthropod. Journal of Experimental Zoology, 307A, 62-66. http://dx.doi.org/10.1002/jez.a.343
|
|
[63]
|
Wang, X.S., Zhu, H.B., Jin, G.L., Liu, H.L., Wu, W.R. and Zhu, J. (2007) Genome-Scale Identification and Analysis of LEA Genes in Rice (Oryza sativa L.). Plant Sciences, 172, 414-420. http://dx.doi.org/10.1016/j.plantsci.2006.10.004
|
|
[64]
|
Olvera-Carrillo, Y., Campos, F., Reyes, J.L., Garciarrubio, A. and Covarrubias, A.A. (2010) Functional Analysis of the Group 4 Late Embryogenesis Abundant Proteins Reveals Their Relevance in the Adaptive Response during Water Deficit in Arabidopsis. Plant Physiology, 154, 373-390. http://dx.doi.org/10.1104/pp.110.158964
|
|
[65]
|
Pla, M., Gómez, J., Goday, A. and Pagès, M. (1991) Regulation of the Abscisic Acid-Responsive Gene rab28 in Maize Viviparous Mutants. Molecular and General Genetics, 230, 394-400. http://dx.doi.org/10.1007/BF00280296
|
|
[66]
|
Kiyosue, T., Yamaguchi-Shinozaki, K., Shinozaki, K., Higashi, K., Satoh, S., Kamada, H. and Harada, H. (1992) Isolation and Characterization of a cDNA That Encodes ECP31, an Embryogenic-Cell Protein from Carrot. Plant Molecular Biology, 19, 239-249. http://dx.doi.org/10.1007/BF00027345
|
|
[67]
|
Boucher, V., Buitink, J., Lin, X., Boudet, J., Hoekstra, F.A., Hundertmark, M., Renard, D. and Leprince, O. (2010) MtPM25 Is an Atypical Hydrophobic Late Embryogenesis-Abundant Protein That Dissociates Cold and Desiccation-Aggregated Proteins. Plant, Cell & Environment, 33, 418-430.
http://dx.doi.org/10.1111/j.1365-3040.2009.02093.x
|
|
[68]
|
Colmenero-Flores, J.M.C., Garciarrubio, F. and Covarrubias, A.A. (1997) Characterization of Phaseolus vulgaris cDNA Clones Responsive to Water Deficit: Identification of a Novel Late Embryogenesis Abundant-Like Protein. Plant Molecular Biology, 35, 393-405. http://dx.doi.org/10.1023/A:1005802505731
|
|
[69]
|
Maskin, L., Frankel, N., Gudesblat, G., Demergasso, M.J., Pietrasanta, L.I. and Iusem, N.D. (2007) Dimerization and DNA-Binding of ASR1, a Small Hydrophilic Protein Abundant in Plant Tissues Suffering from Water Loss. Biochemical and Biophysical Research Communications, 352, 831-835. http://dx.doi.org/10.1016/j.bbrc.2006.11.115
|
|
[70]
|
Silhavy, D., Hutvágner, G., Barta, E. and Bánfalvi, Z. (1995) Isolation and Characterization of a Water-Stress-Inducible cDNA Clone from Solanum chacoense. Plant Molecular Biology, 27, 587-595.
http://dx.doi.org/10.1007/BF00019324
|
|
[71]
|
Oliveira, E., Amara, I., Bellido, D., Odena, M.A., Dominguez, E., Pages, M. and Goday, A. (2007) LCMSMS Identification of Arabidopsis thaliana Heat-Stable Seed Proteins: Enriching for LEA-Type Proteins by Acid Treatment. Journal of Mass Spectrometry, 42, 1485-1495. http://dx.doi.org/10.1002/jms.1292
|
|
[72]
|
Goyal, K., Tisi, L., Basran, A., Browne, J., Burnell, A., Zurdo, J. and Tunnacliffe, A. (2003) Transition from Natively Unfolded to Folded State Induced by Desiccation in an Anhydrobiotic Nematode Protein. The Journal of Biological Chemistry, 278, 12977-12984. http://dx.doi.org/10.1074/jbc.M212007200
|
|
[73]
|
Ismail, A., Hall, A. and Close, T. (1999) Purification and Partial Characterization of a Dehydrin Involved in Chilling Tolerance during Seedling Emergence of Cowpea. Plant Physiology, 120, 237-244.
http://dx.doi.org/10.1104/pp.120.1.237
|
|
[74]
|
Kovacs, D., Agoston, B. and Tompa, P. (2008) Disordered Plant LEA Proteins as Molecular Chaperones. Plant Signaling & Behavior, 3, 710-713. http://dx.doi.org/10.4161/psb.3.9.6434
|
|
[75]
|
Shih, M.D., Lin, S.C., Hsieh, J.S., Tsou, C.H., Chow, T.Y., Lin, T.P. and Hsing, Y.I. (2004) Gene Cloning and Characterization of a Soybean (Glycine max L.) LEA Protein, GmPM16. Plant Molecular Biology, 56, 689-703.
http://dx.doi.org/10.1007/s11103-004-4680-3
|
|
[76]
|
Soulages, J., Kim, K., Arrese, E., Walters, C. and Cushman, J. (2003) Conformation of a Group 2 Late Embryogenesis Abundant Protein from Soybean. Evidence of Poly (L-Proline)-Type II Structure. Plant Physiology, 131, 963-975.
http://dx.doi.org/10.1104/pp.015891
|
|
[77]
|
Soulages, J., Kim, K., Walters, C. and Cushman, J. (2002) Temperature-Induced Extended Helix/Random Coil Transitions in a Group 1 Late Embryogenesis-Abundant Protein from Soybean. Plant Physiology, 128, 822-832.
http://dx.doi.org/10.1104/pp.010521
|
|
[78]
|
Tompa, P. (2005) The Interplay between Structure and Function in Intrinsically Unstructured Proteins. FEBS Letters, 579, 3346-3354. http://dx.doi.org/10.1016/j.febslet.2005.03.072
|
|
[79]
|
Tompa, P. and Kovacs, D. (2010) Intrinsically Disordered Chaperones in Plants and Animals. Biochemistry and Cell Biology, 88, 167-174. http://dx.doi.org/10.1139/O09-163
|
|
[80]
|
Wolkers, W., McCready, S., Brandt, W., Lindsey, G. and Hoekstra, F. (2001) Isolation and Characterization of a D-7 LEA Protein from Pollen That Stabilizes Glasses in Vitro. Biochimica et Biophysica Acta, 1544, 196-206.
http://dx.doi.org/10.1016/S0167-4838(00)00220-X
|
|
[81]
|
Kushwaha, R., Downie, A.B. and Payne, C.M. (2013) Uses of Phage Display in Agriculture: Sequence Analysis and Comparative Modeling of Late Embryogenesis Abundant Client Proteins Suggest Protein-Nucleic Acid Binding Functionality. Computational and Mathematical Methods in Medicine, 2013, 1-11. http://dx.doi.org/10.1155/2013/470390
|
|
[82]
|
Wise, M. (2003) LEAping to Conclusions: A Computational Reanalysis of Late Embryogenesis Abundant Proteins and Their Possible Roles. BMC Bioinformatics, 4, 52. http://dx.doi.org/10.1186/1471-2105-4-52
|
|
[83]
|
Gentile, F., Amodeo, P., Febbraio, F., Picaro, F., Motta, A., Formisano, S. and Nucci, R. (2002) SDS-Resistant Active and Thermostable Dimers Are Obtained from the Dissociation of Homotetrameric Glycosidase from Hyperthermophilic Sulfolobus solfataricus in SDS: Stabilizinz Role of the A-C Intermonomeric Interface. The Journal of Biological Chemistry, 277, 44050-44060. http://dx.doi.org/10.1074/jbc.M206761200
|
|
[84]
|
McCubbin, W., Kay, C. and Lane, B. (1985) Hydrodynamic and Optical Properties of the Wheat Germ Em Protein. Biochemistry and Cell Biology, 63, 803-811. http://dx.doi.org/10.1139/o85-102
|
|
[85]
|
Dunker, A.K., Lawson, J.D., Brown, C.J., Williams, R.M. and Romero, P. (2001) Intrinsically Disordered Protein. Journal of Molecular Graphics and Modelling, 19, 26-59. http://dx.doi.org/10.1016/S1093-3263(00)00138-8
|
|
[86]
|
Tompa, P. (2002) Intrinsically Unstructured Proteins. Trends in Biochemical Sciences, 27, 527-533.
http://dx.doi.org/10.1016/S0968-0004(02)02169-2
|
|
[87]
|
Uversky, V., Gillespie, J. and Fink, A. (2000) Why Are “Natively Unfolded” Proteins Unstructured under Physiologic Conditions? Proteins, 41, 415-427.
http://dx.doi.org/10.1002/1097-0134(20001115)41:3<415::AID-PROT130>3.0.CO;2-7
|
|
[88]
|
Chakraborte, S., Meersman, F., Schierle, G.S., Bertoncini, C.W., McGee, B., Kaminski, C.F. and Tunnacliffe, A. (2010) Catalytic and Chaperone-Like Functions in an Intrinsically Disordered Protein Associated with Desiccation Tolerance. Proceedings of the National Academy of Sciences of the United States of America, 107, 16084-16089.
http://dx.doi.org/10.1073/pnas.1006276107
|
|
[89]
|
Mouillon, J.M., Gustafsson, P. and Harryson, P. (2006) Structural Investigation of Disordered Stress Proteins. Comparison of Full-Length Dehydrins with Isolated Peptides of Their Conserved Segments. Plant Physiology, 141, 638-650. http://dx.doi.org/10.1104/pp.106.079848
|
|
[90]
|
Tolleter, D., Jaquinod, M., Mangavel, C., Passirani, C., Saulnier, P., Manon, S., Teyssier, E., Payet, N., Avelange-Macherel, M.H. and Macherel, D. (2007) Structure and Function of a Mitochondrial Late Embryogenesis Abundant Protein Are Revealed by Desiccation. The Plant Cell Online, 19, 1580-1589.
http://dx.doi.org/10.1105/tpc.107.050104
|
|
[91]
|
Boudet, J., Buitink, J., Hoekstra, F., Rogniaux, H., Larre, C., Satour, P. and Leprince, O. (2006) Comparative Analysis of the Heat Stable Proteome of Radicles of Medicago truncatula Seeds during Germination Identifies Late Embryogenesis Abundant Proteins Associated with Desiccation Tolerance. Plant Physiology, 140, 1418-1436.
http://dx.doi.org/10.1104/pp.105.074039
|
|
[92]
|
Koag, M.-C., Fenton, R.D., Wilkens, S. and Close, T.J. (2003) The Binding of Maize DHN1 to Lipid Vesicles. Gain of Structure and Lipid Specificity. Plant Physiology, 131, 309-316. http://dx.doi.org/10.1104/pp.011171
|
|
[93]
|
Li, D. and He, X. (2009) Desiccation Induced Structural Alterations in a 66-Amino Acid Fragment of an Anhydrobiotic Nematode Late Embryogenesis Abundant (LEA) Protein. Biomacromolecules, 10, 1469-1477.
http://dx.doi.org/10.1021/bm9002688
|
|
[94]
|
Olvera-Carrillo, Y., Reyes, J.L. and Covarrubias, A.A. (2011) Late Embryogenesis Abundant Proteins: Versatile Players in the Plant Adaptation to Water Limiting Environments. Plant Signaling & Behavior, 6, 586-589.
http://dx.doi.org/10.4161/psb.6.4.15042
|
|
[95]
|
Manfre, A., Lanni, L. and Marcotte, W. (2006) The Arabidopsis Group 1 Late-Embryogenesis Abundant Protein ATEM6 Is Required for Normal Seed Development. Plant Physiology, 140, 140-149. http://dx.doi.org/10.1104/pp.105.072967
|
|
[96]
|
Manfre, A.J., LaHatte, G.A., Climer, C.R. and Marcotte, W.R. (2009) Seed Dehydration and the Establishment of Desiccation Tolerance during Seed Maturation Is Altered in the Arabidopsis thaliana Mutant Atem6-1. Plant and Cell Physiology, 50, 243-253. http://dx.doi.org/10.1093/pcp/pcn185
|
|
[97]
|
Nylander, M., Svensson, J., Palva, E.T. and Welin, B.V. (2001) Stress-Induced Accumulation and Tissue-Specific Localization of Dehydrins in Arabidopsis thaliana. Plant Molecular Biology, 45, 263-279.
http://dx.doi.org/10.1023/A:1006469128280
|
|
[98]
|
Brini, F., Hanin, M., Lumbreras, V., Amara, I., Khoudi, H., Hassairi, A., Pagès, M. and Masmoudi, K. (2007) Overexpression of Wheat Dehydrin DHN-5 Enhances Tolerance to Salt and Osmotic Stress in Arabidopsis thaliana. Plant Cell Reports, 11, 2017-2026. http://dx.doi.org/10.1007/s00299-007-0412-x
|
|
[99]
|
Rorat, T., Szabala, B., Grygorowicz, W., Wojtowicz, B., Yin, Z. and Rey, P. (2006) Expression of SK3-Type Dehydrin in Transporting Organs Is Associated with Cold Acclimation in Solanum Species. Planta, 224, 205-221.
http://dx.doi.org/10.1007/s00425-005-0200-1
|
|
[100]
|
Danyluk, J., Perron, A., Houde, M., Limin, A., Fowler, B., Benhamou, N. and Sarhan, F. (1998) Accumulation of an Acidic Dehydrin in the Vicinity of the Plasma Membrane during Cold Acclimation of Wheat. The Plant Cell Online, 10, 623-638. http://dx.doi.org/10.1105/tpc.10.4.623
|
|
[101]
|
Houde, M., Dhindsa, R.S. and Sarhan, F. (1992) A Molecular Marker to Select for Freezing Tolerance in Gramineae. Molecular and General Genetics, 234, 43-48.
|
|
[102]
|
Rorat, T., Grygorowicz, W.J., Irzykowski, W. and Rey, P. (2004) Expression of KS-Type Dehydrins Is Primarily Regulated by Factors Related to Organ Type and Leaf Developmental Stage during Vegetative Growth. Planta, 218, 878-885. http://dx.doi.org/10.1007/s00425-003-1171-8
|
|
[103]
|
Giordani, T., Natali, L., D’Ercole, A., Pugliesi, C., Fambrini, M., Vernieri, P., Vitagliano, C. and Cavallini, A. (1999) Expression of a Dehydrin Gene during Embryo Development and Drought Stress in ABA-Deficient Mutants of Sunflower (Helianthus annuus L). Plant Molecular Biology, 39, 739-748. http://dx.doi.org/10.1023/A:1006194720022
|
|
[104]
|
Welling, A., Rinne, P., Vihera-Aarnio, A., Kontunen-Soppela, S., Heino, P. and Palva, E.T. (2004) Photoperiod and Temperature Differentially Regulate the Expression of Two Dehydrin Genes during Overwintering of Birch (Betula pubescens Ehrh.). Journal of Experimental Botany, 55, 507-516. http://dx.doi.org/10.1093/jxb/erh045
|
|
[105]
|
Plana, M., Itarte, E., Eritja, R., Goday, A., Pagès, M. and Martínez, M.C. (1991) Phosphorylation of Maize RAB-17 Protein by Casein Kinase 2. The Journal of Biological Chemistry, 266, 22510-22514.
|
|
[106]
|
Riera, M., Figueras, M., Lopez, C., Goday, A. and Pages, M. (2004) Protein Kinase CK2 Modulates Developmental Functions of the Abscisic Acid Responsive Protein Rab17 from Maize. Proceedings of the National Academy of Sciences of the United States of America, 101, 9879-9884. http://dx.doi.org/10.1073/pnas.0306154101
|
|
[107]
|
Borovskii, G., Stupnikova, I., Antipina, A., Vladimirova, S. and Voinikov, V. (2002) Accumulation of Dehydrin-Like Proteins in the Mitochondria of Cereals in Response to Cold, Freezing, Drought and ABA Treatment. BMC Plant Biology, 2, 5. http://dx.doi.org/10.1186/1471-2229-2-5
|
|
[108]
|
Heyen, B.J., Alsheikh, M.K., Smith, E.A., Torvik, C.F., Seals, D.F. and Randall, S.K. (2002) The Calcium-Binding Activity of a Vacuole-Associated, Dehydrin-Like Protein Is Regulated by Phosphorylation. Plant Physiology, 130, 675-687. http://dx.doi.org/10.1104/pp.002550
|
|
[109]
|
Cattivelli, L. and Bartels, D. (1990) Molecular Cloning and Characterization of Cold-Regulated Genes in Barley. Plant Physiology, 93, 1504-1510. http://dx.doi.org/10.1104/pp.93.4.1504
|
|
[110]
|
Hsing, Y., Chen, Z., Shih, M., Hsieh, J. and Chow, T. (1995) Unusual Sequences of Group 3 LEA mRNA Inducible by Maturation or Drying in Soybean Seeds. Plant Molecular Biology, 29, 863-868. http://dx.doi.org/10.1007/BF00041175
|
|
[111]
|
Romo, S., Labrador, E. and Dopico, B. (2001) Water Stress-Regulated Gene Expression in Cicer arietinum Seedlings and Plants. Plant Physiology and Biochemistry, 39, 1017-1026. http://dx.doi.org/10.1016/S0981-9428(01)01318-3
|
|
[112]
|
NDong, C., Danyluk, J., Wilson, K.E., Pocock, T., Huner, N.P.A. and Sarhan, F. (2002) Cold-Regulated Cereal Chloroplast Late Embryogenesis Abundant-Like Proteins. Molecular Characterization and Functional Analyses. Plant Physiology, 129, 1368-1381. http://dx.doi.org/10.1104/pp.001925
|
|
[113]
|
Siddiqui, N.U., Chung, H.J., Thomas, T.L. and Drew, M.C. (1998) Abscisic Acid-Dependent and -Independent Expression of the Carrot Late-Embryogenesis-Abundant-Class Gene Dc3 in Transgenic Tobacco Seedlings. Plant Physiology, 118, 1181-1190. http://dx.doi.org/10.1104/pp.118.4.1181
|
|
[114]
|
Curry, J., Morris, C.F. and Walker-Simmons, M.K. (1991) Sequence Analysis of a cDNA Encoding a Group 3 LEA mRNA Inducible by ABA or Dehydration Stress in Wheat. Plant Molecular Biology, 16, 1073-1076.
http://dx.doi.org/10.1007/BF00016078
|
|
[115]
|
Ried, J.L. and Walker-Simmons, M.K. (1993) Group 3 Late-Embryogenesis-Abundant Protein in Desiccation-Tolerant Seedlings of Wheat (Triticum aestivum L.). Plant Physiology, 102, 125-131. http://dx.doi.org/10.1104/pp.102.1.125
|
|
[116]
|
Roberts, J.K., DeSimone, N.A., Lingle, W.L. and Dure III, L. (1993) Cellular Concentrations and Uniformity of Cell-Type Accumulation of Two Lea Proteins in Cotton Embryos. The Plant Cell Online, 5, 769-780.
http://dx.doi.org/10.1105/tpc.5.7.769
|
|
[117]
|
Marttila, S., Tenhola, T. and Mikkonen, A. (1996) A Barley (Hordeum vulgare L.) LEA3 Protein, HVA1, Is Abundant in Protein Storage Vacuoles. Planta, 199, 602-611. http://dx.doi.org/10.1007/BF00195193
|
|
[118]
|
Grelet, J., Benamar, A., Teyssier, E., Avelange-Macherel, M.H., Grunwald, D. and Macherel, D. (2005) Identification in Pea Seed Mitochondria of a Late-Embryogenesis Abundant Protein Able to Protect Enzymes from Drying. Plant Physiology, 137, 157-167. http://dx.doi.org/10.1104/pp.104.052480
|
|
[119]
|
Ukaji, N., Kuwabara, C., Takezawa, D., Arakawa, K. and Fujikawa, S. (2001) Cold Acclimation-Induced WAP27 Localized in Endoplasmic Reticulum in Cortical Parenchyma Cells of Mulberry Tree Was Homologous to Group 3 Late-Embryogenesis Abundant Proteins. Plant Physiology, 126, 1588-1597. http://dx.doi.org/10.1104/pp.126.4.1588
|
|
[120]
|
Cohen, A., Plant, á.L., Moses, M.S. and Bray, E.A. (1991) Organ-Specific and Environmentally Regulated Expression of Two Abscisic Acid-Induced Genes of Tomato. Plant Physiology, 97, 1367-1374.
http://dx.doi.org/10.1104/pp.97.4.1367
|
|
[121]
|
Delseny, M., Bies-Etheve, N., Carles, C., Hull, G., Vicient, C., Raynal, M., Grellet, F. and Aspart, L. (2001) Late Embryogenesis Abundant (LEA) Protein Gene Regulation during Arabidopsis Seed Maturation. Journal of Plant Physiology, 158, 419-427. http://dx.doi.org/10.1078/0176-1617-00353
|
|
[122]
|
Kiyosue, T., Yamaguchi-Shinozaki, K. and Shinozaki, K. (1994) Characterization of Two cDNAs (ERD10 and ERD14) Corresponding to Genes That Respond Rapidly to Dehydration Stress in Arabidopsis thaliana. Plant and Cell Physiology, 35, 225-231.
|
|
[123]
|
Maitra, N. and Cushman, J. (1994) Isolation and Characterization of a Drought-Induced Soybean cDNA Encoding a D95 Family Late-Embryogenesis-Abundant Protein. Plant Physiology, 106, 805-806.
http://dx.doi.org/10.1104/pp.106.2.805
|
|
[124]
|
Zegzouti, H., Jones, B., Frasse, P., Marty, C., Maitre, B., Latché, A., Pech, J.C. and Bouzayen, M. (1999) Ethylene-Regulated Gene Expression in Tomato Fruit: Characterization of Novel Ethylene Responsive and Ripening-Related Genes Isolated by Differential Display. The Plant Journal, 18, 589-600.
http://dx.doi.org/10.1046/j.1365-313x.1999.00483.x
|
|
[125]
|
Niogret, M.F., Culiáñez-Macià, F.A., Goday, A., Albà, M.M. and Pagès, M. (1996) Expression and Cellular Localization of Rab28 mRNA and Rab28 Protein during Maize Embryogenesis. The Plant Journal, 9, 549-557.
http://dx.doi.org/10.1046/j.1365-313X.1996.09040549.x
|
|
[126]
|
Leprince, O. and Buitink, J. (2010) Desiccation Tolerance: From Genomics to the Field. Plant Science, 179, 554-564.
http://dx.doi.org/10.1016/j.plantsci.2010.02.011
|
|
[127]
|
Goday, A., Jensen, A.B., Culianez-Macia, F.A., Alba, M., Figueras, M., Serratosa, M., Torrent, J. and Pagès, M. (1994) The Maize Abscisic Acid-Responsive Protein Rab17 Is Located in the Nucleus and Interacts with Nuclear Localization Signals. Plant Cell, 6, 351-336. http://dx.doi.org/10.1105/tpc.6.3.351
|
|
[128]
|
Hanin, M., Brini, F., Ebel, C., Toda, Y., Takeda, S. and Masmoudi, K. (2011) Plant Dehydrins and Stress Tolerance: Versatile Proteins for Complex Mechanisms. Plant Signaling & Behavior, 6, 1503-1509.
http://dx.doi.org/10.4161/psb.6.10.17088
|
|
[129]
|
Wasilewska, A., Vlad, F., Sirichandra, C., Redko, Y., Jammes, F., Valon, C., Frey, N.F.D. and Leung, J. (2008) An Update on Abscisic Acid Signaling in Plants and More. Molecular Plant, 1, 198-217.
http://dx.doi.org/10.1093/mp/ssm022
|
|
[130]
|
Delahaie, J., Hundertmark, M., Bove, J., Leprince, O., Rogniaux, H. and Buitink, J. (2013) LEA Polypeptide Profiling of Recalcitrant and Orthodox Legume Seeds Reveals ABI3-Regulated LEA Protein Abundance Linked to Desiccation Tolerance. Journal of Experimental Botany, 14, 4559-4573. http://dx.doi.org/10.1093/jxb/ert274
|
|
[131]
|
Guo, F., Liu, C., Xia, H., Bi, Y., Zhao, C., Zhao, S., Hou, L., Li, F. and Wang, X. (2013) Induced Expression of AtLEC1 and AtLEC2 Differentially Promotes Somatic Embryogenesis in Transgenic Tobacco Plants. PLoS ONE, 8, e71714.
http://dx.doi.org/10.1371/journal.pone.0071714
|
|
[132]
|
Grelet, J., Benamar, A., Teyssier, E., Avelange-Macherel, M.-H., Grunwald, D. and Macherel, D. (2005) Identification in Pea Seed Mitochondria of a Late-Embryogenesis Abundant Protein Able to Protect Enzymes from Drying. Plant Physiology, 137, 157-167. http://dx.doi.org/10.1104/pp.104.052480
|
|
[133]
|
Reyes, J., Rodrigo, M.J., Colmenero-Flores, J., Gil, J.V., Garay-Arroyo, A., Campos, F., Salamini, F., Bartels, D. and Covarrubias, A. (2005) Hydrophilins from Distant Organisms Can Protect Enzymatic Activities from Water Limitation Effects in Vitro. Plant, Cell & Environment, 28, 709-718. http://dx.doi.org/10.1111/j.1365-3040.2005.01317.x
|
|
[134]
|
Chakrabortee, S., Boschetti, C., Walton, L.J., Sarkar, S., Rubinsztein, D.C. and Tunnacliffe, A. (2007) Hydrophilic Protein Associated with Desiccation Tolerance Exhibits Broad Protein Stabilization Function. Proceedings of the National Academy of Sciences of the United States of America, 104, 18073-18078.
http://dx.doi.org/10.1073/pnas.0706964104
|
|
[135]
|
Goyal, K., Pinelli, C., Maslen, S.L., Rastogi, R.K., Stephens, E. and Tunnacliffe, A. (2005) Dehydration-Regulated Processing of Late Embryogenesis Abundant Protein in a Desiccation Tolerant Nematode. FEBS Letters, 579, 4093-4098. http://dx.doi.org/10.1016/j.febslet.2005.06.036
|
|
[136]
|
Hatanaka, R., Hagiwara-Komoda, Y., Furuki, T., Kanamori, Y., Fujita, M., Cornette, R., Sakurai, M., Okuda, T. and Kikawada, T. (2013) An Abundant LEA Protein in the Anhydrobiotic Midge, PvLEA4, Acts as a Molecular Shield by Limiting Growth of Aggregating Protein Particles. Insect Biochemistry and Molecular Biology, 11, 1055-1067.
http://dx.doi.org/10.1016/j.ibmb.2013.08.004
|
|
[137]
|
Nakayama, K., Okawa, K., Kakizaki, T., Honma, T., Itoh, H. and Inaba, T. (2007) Arabidopsis Cor15am Is a Chloroplast Stromal Protein That Has Cryoprotective Activity and Forms Oligomers. Plant Physiology, 144, 513-523.
http://dx.doi.org/10.1104/pp.106.094581
|
|
[138]
|
Puhakainen, T., Hess, M., Makela, P., Svensson, J., Heino, P. and Palva, E. (2004) Overexpression of Multiple Dehydrin Genes Enhances Tolerance to Freezing Stress in Arabidopsis. Plant Molecular Biology, 54, 743-753.
http://dx.doi.org/10.1023/B:PLAN.0000040903.66496.a4
|
|
[139]
|
Egerton-Warburton, L.M., Balsamo, R.A. and Close, T.J. (1997) Temporal Accumulation and Ultrastructural Localization of Dehydrins in Zea mays. Physiologia Plantarum, 101, 545-555.
http://dx.doi.org/10.1111/j.1399-3054.1997.tb01036.x
|
|
[140]
|
Koag, M.C., Fenton, R.D., Wilkens, S. and Close, T.J. (2003) The Binding of Maize DHN1 to Lipid Vesicles. Gain of Structure and Lipid Specificity. Plant Physiology, 131, 309-316. http://dx.doi.org/10.1104/pp.011171
|
|
[141]
|
Koag, M.C., Wilkens, S., Fenton, R.D., Resnik, J., Vo, E. and Close, T.J. (2009) The K-Segment of Maize DHN1 Mediates Binding to Anionic Phospholipid Vesicles and Concomitant Structural Changes. Plant Physiology, 150, 1503-1514. http://dx.doi.org/10.1104/pp.109.136697
|
|
[142]
|
Eriksson, S.K., Kutzer, M., Procek, J., Grobner, G. and Harryson, P. (2011) Tunable Membrane Binding of the Intrinsically Disordered Dehydrin Lti30, a Cold-Induced Plant Stress Protein. The Plant Cell, 6, 2391-404l.
http://dx.doi.org/10.1105/tpc.111.085183
|
|
[143]
|
Alsheikh, M., Svensson, J. and Randall, S. (2005) Phosphorylation Regulated Ion-Binding Is a Property Shared by the Acidic Subclass Dehydrins. Plant, Cell & Environment, 28, 1114-1122.
http://dx.doi.org/10.1111/j.1365-3040.2005.01348.x
|
|
[144]
|
Svensson, J., Palva, E.T. and Welin, B. (2000) Purification of Recombinant Arabidopsis thaliana Dehydrins by Metal Ion Affinity Chromatography. Protein Expression and Purification, 20, 169-178.
http://dx.doi.org/10.1006/prep.2000.1297
|
|
[145]
|
Hara, M., Fujinaga, M. and Kuboi, T. (2005) Metal Binding by Citrus Dehydrin with Histidine-Rich Domains. Journal of Experimental Botany, 56, 2695-2703. http://dx.doi.org/10.1093/jxb/eri262
|
|
[146]
|
Buitink, J. and Leprince, O. (2004) Glass Formation in Plant Anhydrobiotes: Survival in the Dry State. Cryobiology, 48, 215-228. http://dx.doi.org/10.1016/j.cryobiol.2004.02.011
|
|
[147]
|
Lin, C. and Thomashow, M. (1992) DNA Sequence Analysis of a Complementary DNA for Cold Regulated Arabidopsis Gene cor15 and Characterization of the COR15 Polypeptide. Plant Physiology, 99, 519-525.
http://dx.doi.org/10.1104/pp.99.2.519
|
|
[148]
|
Hara, M., Shinoda, Y., Tanaka, Y. and Kuboi, T. (2009) DNA Binding of Citrus Dehydrin Promoted by Zinc Ion. Plant, Cell & Environment, 32, 532-541. http://dx.doi.org/10.1111/j.1365-3040.2009.01947.x
|
|
[149]
|
Singh, J., Whitwill, S., Lacroix, G., Douglas, J., Dubuc, E., Allard, G., Keller, W. and Schernthaner, J.P. (2009) The Use of Group 3 LEA Proteins as Fusion Partners in Facilitating Recombinant Expression of Recalcitrant Proteins in E. coli. Protein Expression and Purification, 67, 15-22. http://dx.doi.org/10.1016/j.pep.2009.04.003
|
|
[150]
|
Chakrabortee, S., Meersmanb, F., Schierlec, G.S.K., Bertoncinid, C.W., McGeea, B., Kaminskic, C.F. and Tunnacliffe, A. (2010) Catalytic and Chaperone-Like Functions in an Intrinsically Disordered Protein Associated with Desiccation Tolerance. Proceedings of the National Academy of Sciences, 107, 16084-16089.
http://dx.doi.org/10.1073/pnas.1006276107
|