Thermodynamics of the Second Dissociation Constants (pK₂) of Piperazine-N,N′-bis-2-hydroxypropanesulfonic Acid (POPSO Sesquisodium Salt) and Associated Thermodynamic Functions from (278.15 to 328.15) K

Rabindra N. Roy^*, Lakshmi N. Roy, Katherine E. Hundley, Taylor R. Wehmeyer, Lucas S. Tebbe

Hoffman Department of Chemistry, Drury University, Springfield, MO, USA.

DOI: 10.4236/jbpc.2014.54016                

Abstract

The second acidic dissociation constants of protonated piperazine-N,N′-bis-2-hydroxypropane-sulfonic acid (POPSO sesquisodium salt) have been determined at 12 different temperatures from (278.15 to 328.15) K including 310.15 K. Electromotive-force measurement technique was used employing hydrogen-silver chloride cells without liquid junction. The results of pK₂ are given by the equation: pK₂ = -1041.77/T + 51.0459 - 6.97646lnT. The uncertainty of the fit is ±0.0008. At 289.15 K, pK₂ = 7.8029; whereas, at 310.15 K (body temperature), pK₂ = 7.6862. Thus, the buffer solutions of POPSO and its sodium salt are useful for pH control in the physiological pH region of (7.0 to 8.5). The changes of Gibbs free energy (G°), enthalpy (H°), entropy (S°) and heat capacity Cp° were computed from the temperature derivative of the pK₂ for the dissociation of the zwitterionic acid POPSO^±-3 = POPSO^-4 + H⁺ in the standard state. At 298.15 K, these results are compared with those of similar components, which are the derivatives of the parent compounds TAURINE, PIPERAZINE and MORPHOLINE.

Keywords

pH, Buffer Compound, Liquid Junction, Thermodynamic Functions, Activity Coefficients, Electromotive-Force, pK₂

Conflicts of Interest

The authors declare no conflicts of interest.

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