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Immunotherapy of Cancer—A Historical Note

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DOI: 10.4236/jct.2014.513120    2,621 Downloads   3,117 Views   Citations
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ABSTRACT

We examined the possibility that the anti-estrogens, tamoxifen (TX) and toremifen (TO) interacted with the immune system. Indeed, both TX and TO stimulated cells mediated cytotoxicity reactions by various killer cells: killer T (TK), natural killer (NK), lymphokine activated killer (LAK) cells. Both TX and TO inhibited the growth of tumors that express estrogen receptors. Thus these antiestrogens inhibited tumor growth and stimulated killer cells for cytotoxicty on such tumors. Therefore these agents were presumed to stimulate tumor immunity. We tested the P815 mouse mastcytoma with TK, LK, and TX or TO. A therapeutic effect was observed in both experiments. The SL2-5 murine lymphoma was tested with NK and TX cells or TO cells and successful immunotherapy was observed. We digested human breast carcinomas and lung tumors with collagenase. The killer cells were separated from tumor cells on Ficoll gradients. TX and TO enhanced the cytotoxic effect of autologous killer cells on the corresponding tumor cells. This experiment indicates that the results obtained in animals are also valid for human malignant disease.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Berczi, I. (2014) Immunotherapy of Cancer—A Historical Note. Journal of Cancer Therapy, 5, 1186-1189. doi: 10.4236/jct.2014.513120.

References

[1] Harris, J.E. and Sinkovics, J.G. (1970) The Immunology of Malignant Disease. Mosby, St Louis.
[2] Krupey, J., Gold, P. and Freedmann, S.C. (1967) Purification and Characterization of Carcinoembrionic Antigen of the Human Digestive System. Nature (London), 215, 67.
http://dx.doi.org/10.1038/215067a0
[3] Gorczynski, R.M. (1974) Immunity to Murine Sarcoma Virus Induced Tumors. T Lymphocytes Active in Macrophage Migration Inhibition and Lymphocyte Transformation. Journal of Immunology, 112, 1815-1825.
[4] Oettgen, H.F., Old, J., Mclean, E.P. and Carswel, E.P. (1968) DTH and Transplantation Immunity Elicited by Soluble Antigens of Chemically Induced Tumors in Inbred Guinea Pigs. Nature (London), 220, 295-297. http://dx.doi.org/10.1038/220295a0
[5] Klein, G. (1976) Mechanisms of Escape from Immune Surveillance. Journal of the National Cancer Institute Monographs, 44, 135-136.
[6] Fu, T., Shen, Y. and Fujimoto, S. (2000) Tumor-Specific CD4(+) Suppressor T-Cell Clone Capable of Inhibiting Rejection of Syngeneic Sarcoma in A/J Mice. International Journal of Cancer, 87, 680-687. http://dx.doi.org/10.1002/1097-0215(20000901)87:5<680::AID-IJC10>3.0.CO;2-P
[7] Segerling, H.S., Ohanian, S.M. and Borsos, T. (1975) Chemotherapeutic Drugs Increase Killing of Tumor Cells by Antibody and Complement. Science, 188, 55. http://dx.doi.org/10.1126/science.46622
[8] Nowotny, A. and Butler, R.C. (1979) Studies on the Endotoxin Induced Tumor Resistance. Advances in Experimental Medicine and Biology, 121B, 455-469.
[9] Hershy, P. and McLennon, I.C.M. (1972) Macrophage-Dependent Protection of Tumor Cells. Immunology, 24, 385-393.
[10] Zbar, B., Bernstein, D.D., Bartlett, G.L., Hanna III, M.G. and Rapp, H.G. (1972) Immunotherapy of Cancer: Regression of Intradermal Tumors and Prevention of Growth of Lymph Node Metastasis after Intralesional Injection of Living Mycobacterium bovis. Journal of the National Cancer Institute, 49, 119-130.
[11] Berczi, I. (1972) Studies in Tumor Immunology. Ph.D. Thesis, The University of Manitoba, Winnipeg.
[12] Berczi, I., Strausbauch, P. and Sehon, A.H. (1973) Rejection of Tumor Cells in Vitro. Science, 180, 1289-1291. http://dx.doi.org/10.1126/science.180.4092.1289
[13] Berczi, I. and Sehon, A.H. (1975) Rejection of Tumor Cells in Vitro: A T-Cell Mediated Reaction. International Journal of Cancer, 16, 665-674. http://dx.doi.org/10.1002/ijc.2910160417
[14] Berczi, I. and Sehon, A.H. (1977) Tumor Inhibition by Effector Cells Cultured from Progressing Sarcomas. Immunological Investigations, 6, 617-632.
[15] Berczi, I., Kovács, K., Horváth, E. and Sehon, A.H. (1979) Rejection of Tumor Cells in Vitro: Morphological Studies on Killer T Cells and Damaged Tumor Cells. International Archives of Allergy and Immunology, 59, 1-12. http://dx.doi.org/10.1159/000232233
[16] Kuiper, G.G., Shughrue, P.J., Merchenthaler, I. and Gustafsson, J.?. (1998) The Estrogen Receptor β Subtype: A Novel Mediator of Estrogen Action in Neuroendocrine Systems. Frontiers in Neuroendocrinology, 19, 253-286. http://dx.doi.org/10.1006/frne.1998.0170
[17] Baral, E., Nagy, E. and Berczi, I. (1994) Target Cells Are Sensitized for Cytotoxic T Lymphocyte Mediated Destruction by Estradiol and Tamoxifen. International Journal of Cancer, 58, 64-68.
http://dx.doi.org/10.1002/ijc.2910580112
[18] Baral, E., Nagy, E. and Berczi, I. (1994) Tamoxifen as an Immunomodulatory Agent. In: Berczi, I. and Szelenyi, J., Eds., Advances in Psychoneuroimmunology, Plenum Press, New York, 233-241.
[19] Baral, E., Nagy, E. and Berczi, I. (1995) Modulation of Natural Killer Cell Mediated Cytotoxicity by Tamoxifen and Estradiol. Cancer, 75, 591-599.
[20] Baral, E., Nagy, E. and Berczi, I. (1996) Modulation of Lymphokine-Activated Killer Cell-Mediated Cytotoxicity by Estradiol and Tamoxifen. International Journal of Cancer, 66, 214-218.
[21] Baral, E., Nagy, E., Kangas, L. and Berczi, I. (1996) Anti-Estrogens Enhance the Therapeutic Effect of Lymphokine Activated Killer Cells on the P815 Murine Mastocytoma. International Journal of Cancer, 67, 580-585.
[22] Baral, E., Nagy, E. and Berczi, I. (1996) The Effect of Tamoxifen on the Immune Response. In: Kellen, J.A., Ed., Tamoxifen: Beyond the Antiestrogen, Birkhauser, Boston, 137-178.
http://dx.doi.org/10.1007/978-1-4612-4092-1_7
[23] Nagy, E., Baral, E., Kangas, L. and Berczi, I. (1997) Anti-Estrogens Potentiate the Immunotherapy of the P815 Murine Mastocytoma by Cytotoxic T Lymphocytes. Anticancer Research, 17, 1083-1088.
[24] Baral, E., Nagy, E., Kangas, L. and Berczi, I. (1997) Immunotherapy of the SL2-5 Murine Lymphoma with Natural Killer Cells and Tamoxifen or Toremifene. Anticancer Research, 17, 77-84.
[25] Nagy, E., Baral, E. and Berczi, I. (1999) Immune System. Handbook of Experimental Pharmacology, 135, 343-351.
[26] Berczi, I., Chow, D.A., Baral, E. and Nagy, E. (1998) Neuroimmunoregulation and Cancer. International Journal of Oncology, 13, 1049-1051.
[27] Baral, E., Nagy, E., Krepart, G.E., Lotocki, R.J., Unruh, H.W. and Berczi, I. (2000) Antiestrogens Sensitize Human Ovarian and Lung Carcinomas for Lysis by Autologous Killer Cells. Anticancer Research, 20, 2027-2031.
[28] Haeryfar, S.M.M., Nagy, E., Baral, E., Krepart, G.E., Lotocki, R.J. and Berczi, I. (2000) Antiestrogens Affect both Pathways of Killer Cell-Mediated Oncolysis. Anticancer Research, 20, 1849-1853.
[29] Nagy, E., Berczi, I. and Baral, E. (2001) Combination Immunotherapy of Elsevier Cancer. In: Berczi, I. and Gorczynski, R., Eds., Neuroimmune Biology, Vol. 1: New Foundation of Biology, 417-432.

  
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