Successful Treatment of PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome with Shinbuto*

Yuichirou Tsuji^*, Chitose Karasawa

Department of Pediatrics, Tokyo Takanawa Hospital, Tokyo, Japan.

DOI: 10.4236/ijcm.2014.520160                

Abstract

Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is an autoimmune disorder and the most common disorder characterized by periodic fever in children. A male patient has been followed up from 11 months to 10 years of age because of repeated high fever. We prescribed antifebriles and antibiotics for each febrile episode without a beneficial effect to him each time. He required several days of rest at home to recover from each episode. During his most recent febrile episode at 10 years of age, we prescribed 5.0 g of shinbuto (TJ-30; Tsumura Co., Tokyo, Japan). His fever resolved the next day and he was able to attend school. His growth and development are normal. Shinbuto had a therapeutic effect in this patient with PFAPA syndrome and may be useful in this condition.

Keywords

Periodic Fever, Aphthous, PFAPA Syndrome, Shinbuto

Conflicts of Interest

The authors declare no conflicts of interest.

References

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