Calcitonin Secretion under Insulin Hypoglycemia

Svetlana Stepanovna Moisa¹, Alexander Danilovich Nozdrachev²

¹Federal State-Financed Establishment of Science, State Scientific Center of Russian Federation, Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.
²Pavlov Institute of Physiology Russian Academy of Sciences, St.-Petersburg, Russia.

DOI: 10.4236/ojemd.2014.411023                

Abstract

The increasing secretion of calcitonin and hypocalcemia under insulin hypoglycemia, induced with insulin injection (1 IU/100g), was established. Physiological mechanisms of the stimulating effect of insulin hypoglycemia on calcitonin secretion were studied in double-side adrenalectomized and pancreatectomized rats and under the blocking synaptic transmission in sympathetic ganglions or via peripheral cholino- and adreno-receptor structures. Insulin hypoglycemia didn’t expose the increasing secretion of calcitonin in rats under adrenalectomy and pancreatectomy. Ganglion-blocker pentamin (2.5 mg/100g body weight), blocker of M-cholino-receptors atropine (0.2 ml), α-adreno-blocker tropaphen (0.1 mg/100g), and β-adreno-blocker obzidan (0.1 mg/100g) evoked the inhibiting effect on calcitonin secretion in spite of simultaneously increasing of hypog-lycemia. Corticosteroids and, obviously, glucagon and also the tone of autonomic nervous system via peripheral M-cholinoreactive and α- and β-adrenoreactive structures take part in the activation of calcitonin secretion under insulin hypoglycemia.

Keywords

Calcitonin, Insulin Hypoglycemia, Autonomic Nervous System, Glucocorticoids, Glucagon

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Butakova (Moisa), S.S. and Nozdrachev, A.D. (2010) Effect of One-Time Injection of Calcitonin Preparations on Glucose and Calcium Level in Rats of Different Age Groups. Advances of Gerontology, 23, 93-97.
[2]	Butakova (Moisa), S.S. and Nozdrachev, A.D. (2010) Effect of Calcitonin on the Type of Alimentary Hyperglycemia in Rats of Different Age and Sex. Advances of Gerontology, 23, 213-220.
[3]	Butakova (Moisa), S.S. and Nozdrachev, A.D. (2010) Calcitonin-Glucoregulating Hormone. Vestik of Russian Military Medical Academy, 188-196.
[4]	Moisa, S.S. and Nozdrachev, A.D. (2011) Mechanisms of Hyperglycemic Effect of Calcitonin. Bulletin of Experimental Biology and Medicine, 150, 320-323. http://dx.doi.org/10.1007/s10517-011-1132-3
[5]	Moisa, S.S. and Nozdrachev, A.D. (2011) Mechanisms of Regulation of Calcium and Carbohydrate Metabolism (Monograph). LAP LAMBERT Academic Publishing GmbH & Co. KG, Saarbrucken, 319 p.
[6]	Moisa, S.S. (2013) Calcitonin Contra-Insulin Action on Glucose Metabolism. Bulletin of Experimental Biology and Medicine, 156, 183-185. http://dx.doi.org/10.1007/s10517-013-2314-y
[7]	Moisa, S.S. and Nozdrachev, A.D. (2013) One-Time Injection of Calcitonin Induces Glucose Intolerance in Children with the 1st Degree Obesity. Health, 5, 9-13. http://dx.doi.org/10.4236/health.2013.56A1002
[8]	Moisa, S.S. and Nozdrachev, A.D. (2014) Calcitonin and Parathyrin Are Glucoregulating Hormones. Journal of Molecular and Genetic Medicine, 2, S1-S24. http://dx.doi.org/10.4172/1747-0862
[9]	Butakova (Moisa), S.S. (2005) Calcitonin Secretion under the Different State of Carbohydrate Metabolism in Ontogenesis in Rats. Materials of the VII All-Russian Conference “Neuroendocrinology-2005”, St.-Petersburg, 25-27 April 2005, 36-37.
[10]	Butakova (Moisa), S.S. (2007) Serum Calcitonin Activity and Total Calcium Content under the Different State of Carbohydrate Metabolism in Ontogenesis in Rats. Pavlov Institute of Physiology Russian Academy of Sciences. St.-Pe-tersburg, 7-9 October 2007, p. 32.
[11]	Nozdrachev, A.D., Poliakov, E.L. and Bagaev, V.A. (2007) Experimental Surgery of the Laboratory Animals. Lan, St.-Petersburg, 125 and 130-132.
[12]	Frank, H. and Kirberger, E. (1950) Eine Kolorimetrische Methode zur Bestimmung der “Wahren Glucose” und Galactose in 0.005 rm3. Blut. Biochem. Ztschr., 320, 359-367.
[13]	Laljee, H.C.K., Smith, K.I. and Dorrington, K.J. (1967) The Assay of Human Thyrocalcitonin in Mice. Proccedings of the Symposium on Thyrocalcitonin and the C-Cells, London, 17-20 July 1967, 32-35.
[14]	Selochnik, I.I., Briskin, A.I. and Antonova, E.E. (1978) Photoelectrocolorimetric Assay of Calcium Concentration in Serum by the Help of EDTA and Murexide. Chemical Pharmacological Journal, 12, 138-140.
[15]	Usvatova, I.Y. and Pankov, Y.A. (1969) Fluorimetrical Methods of the Determination of Steroid Hormones in Biological Fluids. Medicine, Moscow, 38.
[16]	Lineberry, M.P. and Waite, L.C. (1978) Calcitonin Responses in Intact and Adrenalectomized Rats. Life Sciences, 22, 511-518. http://dx.doi.org/10.1016/0024-3205(78)90432-0
[17]	Shustov, S.B. and Halimov, Y.S. (2001) Functional and Topical Diagnostic in Endocrinology. Elbi, St.-Petersburg, 238 p.
[18]	Zbucki, R.L., Dadan, I., Sawicki, B., Bialuk, I., Kosiozek, P., Winnicka, M. and Puchalski, Z. (2004) Propranolol Alters the Activity of Thyroid C-Cells in the Experimental Model of Hyperthyroidism in Rats. Proceedings of the 15 International Congress of the Polish Pharmacological Society, Poznan, 12-14 September 2004, 223.
[19]	Ahren, B. (2000) Automatic Regulation of Islet Hormone Secretion—Implications for Health and Disease. Diabetologia, 43, 393-410. http://dx.doi.org/10.1007/s001250051322
[20]	Butakova (Moisa), S.S. (2008) Calcitonin, a Modulater of Pancreas Secret Process. Thesis, Institute of Physiology of the Russian Academy of Sciences, St.-Petersburg, 26-27.
[21]	Iaroshevskii, I.A., Darinskii, I.A. and Butakova (Moisa), S.S. (1989) Calcitonin Effect on Insulin and Glucagon Secretion by Panceas. Problems of Endocrinology, 35, 58-61.
[22]	Moore, M.C., Lin, D.W., Colburn, C.A., Goldstein, R.E., Neal, D.W. and Cherrington, A.D. (1999) Insulin- and Glucagons-Independent Effects of Calcitonin Gene-Related Peptide in the Conscious Dog. Metabolism, 48, 603-610.http://dx.doi.org/10.1016/S0026-0495(99)90058-6
[23]	Moisa, S.S. and Nozdrachev, A.D. (2013) Effect of Calcium-Regulating Hormones on Glucose Tolerance. Proceedings of Materials of the III International Research and Practice Conference: Science, Technology and Higher Education, Westwood, 16 October 2013, 516-522.
[24]	Young, A.A., Wang, M.W. and Gedulin, B. (1995) Diabetogenic Effects of Salmon Calcitonin Are Attributable to Amylin-Like Activity. Metabolism, 44, 1581-1589. http://dx.doi.org/10.1016/0026-0495(95)90079-9