Lymphomatoid Granulomatosis as a Debut of Common Variable Immunodeficiency: A Case Report and Review of Literature


Lymphomatoid granulomatosis, currently called as extranodal angiocentric and angiodestructive immunoproliferative disorder, is a rare entity of unclear etiology. It involves most frequently lungs, central nervous system and skin. The clinical course is variable, but mortality is high. Today, it represents a diagnostic challenge because it can emulate autoimmunity, infection, and malignancy processes. Optimal therapy scheme is still unknown. We report the case of a 20 year-old man presenting with fever, weight loss, sweating, multiple bilateral lung nodules on the chest X-ray and cutaneous involvement.

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Fernández-García, M. , Zhuravetska, T. , Rodríguez, J. and Ots, E. (2014) Lymphomatoid Granulomatosis as a Debut of Common Variable Immunodeficiency: A Case Report and Review of Literature. Journal of Biosciences and Medicines, 2, 13-15. doi: 10.4236/jbm.2014.28002.

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The authors declare no conflicts of interest.


[1] Swerdlow, S., Campo, E., Lee Harris, N., Jaffe, E., Pileri, S., Stein, H., et al. (2008) WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. IARC Press, Lyon.
[2] Inaba, M., Ushijim, S., Hirata, N., Saisyoji, T., Kitaoka, M. and Yoshinaga, T. (2011) Methotrexate-Related Lymphomatoid Granulomatosis in a Patient with Rheumatoid Arthritis. Nihon Kokyuki Gakkai Zasshi, 49, 597-601.
[3] Wyen, C., Stenzel, W., Hoffmann, C., Lehmann, C., Deckert, M. and Fatkenheuer, G. (2007) Fatal Cerebral Lymphomatoid Granulomatosis in an HIV-1-Infected Patient. Journal of Infection, 54, 175-178.
[4] Cunningham-Rundles, C. and Bodian, C. (1999) Common Variable Immunodeficiency: Clinical and Immunological Features of 248 Patients. Clinical Immunology, 92, 34-48.
[5] Váróczy, L., Gergely, L., Szakáll, S. and Illés, A. (2002) Angiocentric lymphomatoid Granulomatosis and Severe Hypogammaglobulinaemia. Haematologia, 32, 535-541.

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