Renal Amyloidosis Following Chronic Osteomyelitis in a Patient with Congenital Insensitivity to Pain and Anhidrosis

Sevgi Yavuz^*, Aydin Ece

Division of Pediatric Nephrology, Dicle University, Diyarbakir, Turkey.

DOI: 10.4236/ojped.2014.43032                

Abstract

Congenital insensitivity to pain and anhidrosis (CIPA) is a rare form of hereditary sensory and autonomic neuropathy. It is characterized by impaired perception of pain and temperature, anhidrosis and intellectual disability. Self mutilating behaviors lead to accidental injuries. The limb lesions are often infected and frequently progress to chronic osteomyelitis. In pediatrics, amyloidosis usually occurs secondary to chronic inflammatory diseases. The coexistence of amyloidosis and CIPA has not previously been reported in literature. A CIPA case complicated with nephrotic syndrome and renal amyloidosis following chronic osteomyelitis is presented here. This report emphasizes the importance of close follow-up of patients by urine analysis for the risk of developing amyloidosis particularly in the presence of chronic infections.

Keywords

Pain Insensitivity, Anhidrosis, Osteomyelitis, Nephrotic Syndrome, Amyloidosis

Conflicts of Interest

The authors declare no conflicts of interest.

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