Adherence of a Clinical Strain of Mycoplasma fermentans to Human Cultured Epithelial Cells


This study compares the kinetics of adherence of both the prototype strain PG-18 and the recently clinically isolated strain P-140 of Mycoplasma fermentans to HEp-2 cells. M. fermentans may induce respiratory and genitourinary tract infections. We investigated the presence of putative adhesins from strain P-140. A surface protein of 47 kDa, labeled SP47, isolated from M. fermentans P-140, seems to be involved in acterial adherence on HEp-2 cells; this study could allow helping understand the interaction between mycoplasmas and their hosts. Anti-SP47 antibodies inhibited the formation of bacterial clusters and adherence to cultured cells, quantified by ELISA. M. fermentans P-140 was more efficient at adhering to cultured HEp-2 cells than PG-18.

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Rosales-Pérez, M. , Giono-Cerezo, S. , Girón, J. , Yáñez, A. and Cedillo, L. (2014) Adherence of a Clinical Strain of Mycoplasma fermentans to Human Cultured Epithelial Cells. Advances in Microbiology, 4, 726-735. doi: 10.4236/aim.2014.411079.

Conflicts of Interest

The authors declare no conflicts of interest.


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