Combination of the MODS Assay with the Sensititre^TM MYCOTB Plate for Rapid Detection of MDR- and XDR-TB

Parichat Salee, La’Chia Harrison, Kim Dionne, Carole McArthur, Nicole Parrish

Chiang Mai University, Chiang Mai, Thailand; The Johns Hopkins University, Baltimore, USA.
The Johns Hopkins University, Baltimore, USA.
University of Missouri, Kansas City, USA.

DOI: 10.4236/jtr.2014.23012                

Abstract

We combined the new Sensititre^TM MYCOTB test with the MODS assay for detection of MDR- and XDR-TB. Categorical agreement of the MODS assay with the critical concentrations at 3 days of incubation was highest for INH (91.4%) and RIF (100%) and at 5 days 86.7% and 94.6% for the fluoroquinolones and aminoglycosides, respectively. By combining these two methods, it is possible to identify MDR-TB in as little as 3 days and XDR- or pre-XDR-TB within 5 days.

Keywords

Tuberculosis, Susceptibility Testing, MODS, MYCOTB, MDR-TB, XDR-TB

Conflicts of Interest

The authors declare no conflicts of interest.

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