Complete Remission by Primary Chemotherapy of Advanced Non-Seminomatous Germ Cell Tumor in an Intra-Abdominal Testis


Ectopic testis predisposes to a high risk of germ cell tumor development. Treatment of advanced testicular germ cell tumor developing in an uncorrected abdominal testis is based on primary chemotherapy followed by removal of the testis along with residual masses. However, persistence of viable tumor particularly in the testis is always noted since testis penetration of chemotherapeutic agents is reduced. We report a case of complete pathological remission of a patient with advanced non-seminomatous germ cell tumor in intra-abdominal testis by primary chemotherapy alone, with a review of the literature.

Share and Cite:

Sarkis, P. , Kourie, H. , Gharios, J. and Kattan, J. (2014) Complete Remission by Primary Chemotherapy of Advanced Non-Seminomatous Germ Cell Tumor in an Intra-Abdominal Testis. Open Journal of Urology, 4, 105-108. doi: 10.4236/oju.2014.48018.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Kuo, J.Y., Huang, W.J., Chiu, A.W., Chen, K.K. and Chang, L.S. (1999) Clinical Experiences of Germ Cell Tumor in Cryptorchid Testis. The Kaohsiung Journal of Medical Sciences, 15, 32-37.
[2] Wood, H.M. and Elder, J.S. (2009) Cryptorchidism and Testicular Cancer: Separating Fact from Fiction. The Journal of Urology, 181, 452-461.
[3] Batata, M.A., Chu, F.C., Hilaris, B.S., Whitmore, W.F. and Golbey, R.B. (1982) Testicular Cancer in Cr-
yptorchids. Cancer, 49, 1023-1030.<1023::AI
[4] A.A., Darzi, Aliramaji, A. and Ramezani, M.S. (2010) Unresolved Abdominal Mass in an Adult Cryptorchid Testis: A Case Report. International Journal of General Medicine, 3, 395-398.
[5] Kuo, J.Y., Chiu, A.W., Chen, K.K. and Chang, L.S. (1999) Life-Threatening Germ Cell Tumor Arising in Cryptorchidism: A Case Report. Zhonghua Yi Xue Za Zhi (Taipei), 62, 116-120.
[6] International Germ Cell Cancer Collaborative Group (1997) International Germ Cell Consensus Classification: A Prognostic Factor-Based Staging System for Metastatic Germ Cell Cancers. Journal of Clinical Oncology, 15, 594-603.
[7] Morelli, F., Tozzi, L., Setola, P., Bisceglia, M., Barbini, V.R. and Maiello, E. (2006) Postchemotherapy Residual Masses in Germ Cell Tumor Patients: Our Experience. Annals of Oncology, 17, 132-136.
[8] Ries, L.A., Eisner, M.P., Kosary, C.L., et al. (2004) SEER Cancer Statistics Review, 1975-2001. National Cancer Institute, Bethesda, MD.
[9] Moran-Ribon, A., Droz, J.P., Kattan, J., Leclercq, B., Ghosn, M., Couanet, D., et al. (1994) Super-High-Risk Germ-Cell Tumors: A Clinical Entity. Supportive Care in Cancer, 2, 253-258.
[10] Ondrus, D., Hornák, M, Breza, J., Mat’oska, J., Schnorrer, M., Belan, V., et al. (2001) Delayed Orchiectomy after Chemotherapy in Patients with Advanced Testicular Cancer. International Urology and Nephrology, 32, 665-667.
[11] Dave, D.S., Leppert, J.T. and Rajfer, J. (2007) Is the Testis a Chemo-Privileged Site? Is There a Blood-Testis Barrier? Reviews in Urology, 9, 28-32.
[12] James, P.P. and Mead, G.M. (1992) Sanctuary Site Relapse in Chemotherapy-Treated Testicular Cancer. Annals of Oncology, 3, 41-43.
[13] Snow, B.W., Rowland, R.G., Donohue, J.P., Einhorn, L.H. and Williams, S.D. (1983) Review of Delayed Orchiectomy in Patients with Disseminated Testis Tumors. Journal of Urology, 129, 522-523.
[14] Kulkarni, J.N., Desai, S.M., Phadke, G.K. and Tongaonkar, H.B. (1996) Improved Management of Abdominal Undescended Testicular tumors with Bulky Confluent Retroperitoneal Nodal Metastases. Journal of Urology, 156, 1341-1344.
[15] Fizazi, K., Culine, S., Kramar, A., Amato, R.J., Bouzy, J., Chen, I., et al. (2004) Early Predicted Time to Normalization of Tumor Markers Predicts Outcome in Poor-Prognosis Nonseminomatous Germ Cell Tumors. Journal of Clinical Oncology, 22, 3868-3876.

Copyright © 2022 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.